Fei H, Zhang XJ, Sun CY, Li Z, Li ZF, Guo CG, Zhao DB. Impact of perioperative blood transfusion on oncological outcomes in ampullary carcinoma patients underwent pancreaticoduodenectomy. World J Gastrointest Surg 2023; 15(7): 1363-1374 [PMID: 37555106 DOI: 10.4240/wjgs.v15.i7.1363]
Corresponding Author of This Article
Dong-Bing Zhao, MD, Professor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing 100021, China. dbzhao@cicams.ac.cn
Research Domain of This Article
Surgery
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
He Fei, Xiao-Jie Zhang, Chong-Yuan Sun, Zheng Li, Ze-Feng Li, Chun-Guang Guo, Dong-Bing Zhao, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Author contributions: Fei H and Zhang XJ contributed equally to this work; Guo CG and Zhao DB designed the research study; Fei H and Zhang XJ analyzed the data; all authors wrote the manuscript; all authors have read and approve the final manuscript.
Institutional review board statement: This study was approved by the National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Ethics Committee.
Informed consent statement: Ethical review and approval were not required for the study on human participants in accordance the local legislation and institutional requirements.
Conflict-of-interest statement: None of the authors have conflicts of interest related to the manuscript.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dong-Bing Zhao, MD, Professor, Department of Pancreatic and Gastric Surgical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Panjiayuan Nanli, Beijing 100021, China. dbzhao@cicams.ac.cn
Received: February 1, 2023 Peer-review started: February 1, 2023 First decision: February 14, 2023 Revised: March 5, 2023 Accepted: May 17, 2023 Article in press: May 17, 2023 Published online: July 27, 2023
ARTICLE HIGHLIGHTS
Research background
Numerous patients require transfusion due to sophisticated surgical procedures. However, the effect of perioperative blood transfusion (PBT) on the oncologic outcomes of ampullary carcinoma (AC) is still debated.
Research motivation
The present study attempted to explore the impact of PBT on short-term safety and long-term survival in AC patients who underwent pancreaticoduodenectomy.
Research objectives
This study aimed to investigate whether there was an association between PBT and poor oncologic outcomes in AC.
Research methods
The clinicopathological data of AC patients who underwent surgery from January 1998 to January 2020 were analyzed. We used Cox proportional hazard regression to identify prognostic factors of overall survival (OS) and recurrence-free survival (RFS) and the Kaplan-Meier method to analyze survival information.
Research results
Patients who received transfusion had a comparable incidence of postoperative complications with patients who did not. Transfusion was not an independent predictor of OS and RFS, while PBT might be potentially associated with decreased OS in early AC.
Research conclusions
We found that PBT might be associated with decreased OS in early AC.
Research perspectives
There are several limitations in this retrospective study, and more multicenter and prospective validations are needed.
