Zhang Y, Zhao X, Gao C, Lin LY, Li Y. Treatment outcome analysis of bevacizumab combined with cyclophosphamide and oxaliplatin in advanced pseudomyxoma peritonei. World J Gastrointest Surg 2023; 15(6): 1149-1158 [PMID: 37405093 DOI: 10.4240/wjgs.v15.i6.1149]
Corresponding Author of This Article
Yan Li, MD, PhD, Doctor, Surgical Oncologist, Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian Street, Haidian District, Beijing 100038, China. liyansd2@mail.ccmu.edu.cn
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jun 27, 2023; 15(6): 1149-1158 Published online Jun 27, 2023. doi: 10.4240/wjgs.v15.i6.1149
Treatment outcome analysis of bevacizumab combined with cyclophosphamide and oxaliplatin in advanced pseudomyxoma peritonei
Ying Zhang, Xin Zhao, Chao Gao, Lin-Yu Lin, Yan Li
Ying Zhang, Xin Zhao, Chao Gao, Lin-Yu Lin, Yan Li, Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Author contributions: Zhao X and Gao C collected the data; Zhang Y and Lin LY performed the data analysis; Zhang Y wrote the original draft preparation; Zhang Y and Li Y wrote the review and editing; Li Y contributed to the supervision.
Supported byBeijing Municipal Administration of Hospitals’ Ascent Plan, No. DFL20180701; and Beijing Municipal Grant for Medical Talents Group on Peritoneal Surface Oncology, No. 2017400003235J007.
Institutional review board statement: This study was reviewed and approved by the ethics committee of Beijing Shijitan Hospital, Capital Medical University, No. sjtkyll-lx-2022(066).
Informed consent statement: All study participants or their legal guardian provided written informed consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: We have no data to share.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yan Li, MD, PhD, Doctor, Surgical Oncologist, Department of Peritoneal Cancer Surgery, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi Road, Yangfangdian Street, Haidian District, Beijing 100038, China. liyansd2@mail.ccmu.edu.cn
Received: March 8, 2023 Peer-review started: March 8, 2023 First decision: March 15, 2023 Revised: March 18, 2023 Accepted: April 14, 2023 Article in press: April 14, 2023 Published online: June 27, 2023 Processing time: 99 Days and 8.4 Hours
ARTICLE HIGHLIGHTS
Research background
Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy is its standard treatment. But for systemic chemotherapy of advanced pseudomyxoma peritonei (PMP), there are currently few studies and insufficient evidence.
Research motivation
Regimens for colorectal cancer are often used clinically, but there is no uniform standard for late-stage treatment.
Research objectives
The purpose of this single-center, retrospective study was to determine if bevacizumab combined with cyclophosphamide and oxaliplatin (Bev+CTX+OXA) is effective for treatment of advanced PMP.
Research methods
Retrospective analysis was conducted on the clinical data of patients with advanced PMP who received Bev+CTX+OXA regimen from December 2015 to December 2020. Objective response rate (ORR), disease control rate (DCR) and incidence of adverse events were evaluated. Progression-free survival (PFS) was followed up.
Research results
A total of 32 patients were enrolled, after 2 cycles, ORR and DCR were 3.1% and 93.7% respectively. The median follow-up time was 7.5 mo. During the follow-up period, 14 patients (43.8%) had disease progression, and the median progression-free survival (PFS) was 8.9 mo. Stratified analysis showed that the PFS of patients with preoperative increase of CA125 (8.9 vs 2.1, P = 0.022) and completeness of cytoreduction score of 2-3 (8.9 vs 5.0, P = 0.043) were significantly longer than those of the control group. Multivariate analysis showed that preoperative increase of CA125 was an independent prognostic factor for PFS (HR = 0.245, 95%CI: 0.066-0.904, P = 0.035).
Research conclusions
Bev+CTX+OXA regimen is certain effective in the posterior-line treatment of advanced PMP, and the adverse reactions can be tolerated. The preoperative increase of CA125 is an independent prognostic factor of PFS.
Research perspectives
More sample size should be conduct in the future to validate the conclusion of our study.
