Tong H, Xing P, Ji ZN. Correlation between pre-treatment serum total blood bilirubin and unconjugated bilirubin and prognosis in patients with colorectal cancer. World J Gastrointest Surg 2023; 15(11): 2456-2462 [PMID: 38111770 DOI: 10.4240/wjgs.v15.i11.2456]
Corresponding Author of This Article
Zhao-Ning Ji, Doctor, MD, Chief Doctor, Department of Medicine Oncology, The First Affiliated Hospital of Wannan Medical College-Yijishan Hospital, No. 2 Zheshan West Road, Wuhu 241000, Anhui Province, China. jzn18963705636@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2456-2462 Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2456
Correlation between pre-treatment serum total blood bilirubin and unconjugated bilirubin and prognosis in patients with colorectal cancer
Hui Tong, Peng Xing, Zhao-Ning Ji
Hui Tong, Peng Xing, Department of Medicine Oncology, Anhui Jingxian Hospital, Xuancheng 242500, Anhui Province, China
Zhao-Ning Ji, Department of Medicine Oncology, The First Affiliated Hospital of Wannan Medical College-Yijishan Hospital, Wuhu 241000, Anhui Province, China
Author contributions: Ji ZN designed the research; Tong H performed the research; Ji ZN and Xing P contributed new reagents or analytic tools; Tong H analyzed data and wrote the paper.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Jingxian Hospital in Anhui Province.
Informed consent statement: As the study used anonymous and pre-existing data, the requirement for informed consent from patients was waived.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhao-Ning Ji, Doctor, MD, Chief Doctor, Department of Medicine Oncology, The First Affiliated Hospital of Wannan Medical College-Yijishan Hospital, No. 2 Zheshan West Road, Wuhu 241000, Anhui Province, China. jzn18963705636@163.com
Received: August 9, 2023 Peer-review started: August 9, 2023 First decision: August 24, 2023 Revised: August 29, 2023 Accepted: September 20, 2023 Article in press: September 20, 2023 Published online: November 27, 2023 Processing time: 110 Days and 1.2 Hours
ARTICLE HIGHLIGHTS
Research background
Epidemiological studies have found that unconjugated bilirubin (UCB) levels are positively correlated with the incidence of colorectal cancer (CRC).
Research motivation
Therefore, we speculate that bilirubin may also play an important role in the prognosis of CRC.
Research objectives
To investigate the predictive value of total bilirubin (TBIL) and UCB in the prognosis of patients with CRC.
Research methods
A total of 142 CRC patients were selected as the research subjects in Jingxian Hospital, from October 2014 to May 2021. General and tumour-related clinical data at admission and the overall survival at 3 years after surgery were collected. The optimal cut-off values of TBIL and UCB were determined by receiver operating characteristic curve analysis. Univariate and multivariate Cox regression were used to analyse the effect of bilirubin level on the survival of CRC patients. The Kaplan–Meier method was used to assess the survival time.
Research results
The 3-year overall survival rate of CRC patients was significantly higher in the high TBIL (> 13.45 μmol/L) group than in the low TBIL (≤ 13.45 μmol/L) group (76.4% vs 37.1%; P < 0.05). The 3-year overall survival rate of CRC patients in the high UCB (> 10.75 μmol/L) group was significantly higher than that in the low UCB (≤ 10.75 μmol/L) group (83.3% vs 34.2%; P < 0.05). Multivariate Cox regression analysis showed that higher TBIL levels were an independent predictor of better prognosis in CRC patients (hazard ratio = 0.360, 95% confidence interval: 0.159-0.812, P = 0.014).
Research conclusions
TBIL levels can be used as a prognostic indicator for CRC patients.
Research perspectives
To investigate the role of TBIL and UCB in the prognosis of patients with CRC.
