Retrospective Study
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Nov 27, 2023; 15(11): 2423-2429
Published online Nov 27, 2023. doi: 10.4240/wjgs.v15.i11.2423
Effect of laparoscopic sleeve gastrectomy on related variables of obesity complicated with polycystic ovary syndrome
Xiao-Tao Wang, Yi-Sen Hou, Hao-Liang Zhao, Jian Wang, Chen-Hao Guo, Jie Guan, Zhi-Gan Lv, Peng Ma, Jian-Li Han
Xiao-Tao Wang, Yi-Sen Hou, Hao-Liang Zhao, Jian Wang, Chen-Hao Guo, Jie Guan, Peng Ma, Jian-Li Han, Department of Thyroid & Bariatric Metabolic Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, Shanxi Province, China
Zhi-Gan Lv, Department of Anesthesia, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan 030032, Shanxi Province, China
Author contributions: Wang XT and Han JL contributed to protocol/project development; Wang XT, Hou YS, Zhao HL, Wang J, Guo CH, and Han JL contributed to data collection or management; Wang XT, Guan J, Lv ZG, Ma P, and Han JL contributed to data analysis; Wang XT, and Han JL contributed to manuscript writing/editing; All authors reviewed the manuscript.
Supported by Shanxi Province “136” Revitalization Medical Project Construction Funds, No. 2019XY003.
Institutional review board statement: The study was reviewed and approved by the Shanxi Bethune Hospital,Shanxi Academy of Medical Sciences Review Board.
Informed consent statement: All study participants or their legal guardian provided informed written consent about personal and medical data collection prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Li Han, Doctor, Chief Physician, Department of Thyroid & Bariatric Metabolic Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, No. 99 Longcheng Street, Taiyuan 030032, Shanxi Province, China. hjl13803456545@126.com
Received: August 7, 2023
Peer-review started: August 7, 2023
First decision: August 24, 2023
Revised: September 18, 2023
Accepted: October 11, 2023
Article in press: October 11, 2023
Published online: November 27, 2023
ARTICLE HIGHLIGHTS
Research background

Polycystic ovary syndrome (PCOS) is a common endocrine disease in young women, with a prevalence rate of 5%-18%. PCOS is closely related to obesity, and an increase in obesity will enhance the severity and expression of the PCOS phenotype.

Research motivation

The efficacy of laparoscopic sleeve gastrectomy (LSG) for obesity with PCOS are still unclear.

Research objectives

The purpose of the study was to investigate the effect of LSG on related variables in obese patients with PCOS.

Research methods

The clinical data of 32 patients who were diagnosed with obesity complicated with polycystic ovary syndrome and underwent laparoscopic sleeve gastrectomy from January 2013 to December 2020 were reviewed. The changes in anthropometric indices, insulin, testosterone, estradiol, follicle stimulating hormone (FSH), luteinizing hormone (LH), menstrual cycle and LH/FSH ratio before and 1 mo, 3 mo, 6 mo and 12 mo after the operation were statistically analyzed.

Research results

The patient's body mass and BMI were basically stable at 1 year after the operation. During the postoperative period, the average level of estradiol increased; the average serum testosterone and the insulin level decreased significantly after the operation. On the other hand, after surgical treatment, it was found that the average ratio was less than 1, indicating that the average FSH level after bariatric surgery was higher than that of LH.

Research conclusions

Laparoscopic sleeve gastrectomy can improve hyperandrogenaemia and irregular menstruation in obese patients with polycystic ovary syndrome, significantly reduce weight loss and improve a series of complications related to polycystic ovary syndrome.

Research perspectives

The impact of laparoscopic sleeve gastrectomy on obese patients with polycystic ovary syndrome's physical, hormonal and reproductive indicators.