Published online Jan 27, 2023. doi: 10.4240/wjgs.v15.i1.49
Peer-review started: September 20, 2022
First decision: October 5, 2022
Revised: October 18, 2022
Accepted: December 21, 2022
Article in press: December 21, 2022
Published online: January 27, 2023
Nearly 66% of instances of gastric cancer (GC), which has the second-highest death rate of all cancers, occur in developing countries. The only curative treatment for patients is considered to be a radical surgery, which increases the likelihood of a successful cure and lengthens patient survival.
The high likelihood of cancer recurrence means that the 5-year overall survival (OS) is still poor even after surgery. The tumor node metastasis (TNM) stage is connected with the prognosis of GC patients, but it is difficult to determine prior to surgery.
To investigate more clinical characteristics and develop a specific nomogram to forecast OS for GC patients.
Nine hundred and four GC patients treated at the First Affiliated Hospital of Anhui Medical University between January 2010 and January 2013 were recruited. Prognostic risk variables were screened using the Cox analysis. The C-index and receiver operator characteristic (ROC) curve were used to construct and evaluate the nomogram.
TNM stage, carcinoembryonic antigen, systemic immune-inflammation index, and age were identified as independent predictive variables by multivariate analysis. The systemic immune-inflammation index value was superior to that of other inflammatory indicators. The ROC indicated the nomogram had a higher area under the curve than other factors, and its C-index for assessing the validation and training groups of GC patients was extremely reliable.
We created a novel nomogram to predict the prognosis of GC patients following curative gastrectomy based on the blood markers and other characteristics.
Both surgeons and patients can benefit significantly from this new scoring system. The nomogram may be used more frequently in clinics.