Li YQ, Pan SB, Yan SS, Jin ZD, Huang HJ, Sun LQ. Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms: A retrospective study with a large sample size. World J Gastrointest Surg 2022; 14(2): 174-184 [PMID: 35317543 DOI: 10.4240/wjgs.v14.i2.174]
Corresponding Author of This Article
Li-Qi Sun, MD, Assistant Professor, Department of Gastroenterology, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. zjhzslqsmmu@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2022; 14(2): 174-184 Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.174
Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms: A retrospective study with a large sample size
Yu-Qiong Li, Shu-Bo Pan, Zhen-Dong Jin, Hao-Jie Huang, Li-Qi Sun, Department of Gastroenterology, Changhai Hospital, Shanghai 200433, China
Shu-Bo Pan, Department of Gastroenterology, Suzhou Science and Technology Town Hospital, Suzhou 215000, Jiangsu Province, China
Shu-Shu Yan, Department of Anesthesiology, Changhai Hospital, Shanghai 200433, China
Li-Qi Sun, Department of Gastroenterology, 72nd Group Army Hospital, Huzhou University, Huzhou 313000, Zhejiang Province, China
Author contributions: Li YQ, Pan SB and Yan SS contributed equally to this study and are co-first authors, were responsible for study design/planning, study conduct, data analysis and writing and revising the paper; Huang HJ and Sun LQ designed the study and they shared senior authorship; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Shanghai Changhai Hospital Ethics Committee (CHEC No. 2019-091).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Qi Sun, MD, Assistant Professor, Department of Gastroenterology, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. zjhzslqsmmu@qq.com
Received: October 7, 2021 Peer-review started: October 7, 2021 First decision: December 4, 2021 Revised: December 9, 2021 Accepted: January 25, 2022 Article in press: January 25, 2022 Published online: February 27, 2022
ARTICLE HIGHLIGHTS
Research background
Conventional surgical methods (CM) including pancreatoduodenectomy (PD), total pancreatectomy (TP) and distal pancreatectomy are standard surgical methods in the treatment of patients with Solid pseudopapillary neoplasm (SPN). CM is associated with a high rate of morbidity. However, the tumor mainly affects young women and the prognosis of the tumor is excellent.
Research motivation
The parenchyma-preserving surgical methods (PPM, including enucleation and central pancreatectomy ) are more and more often applied in clinical practice. The role of PPM in treating SPN remains clarified.
Research objectives
To evaluate the impact of PPM in the treatment of SPN patients.
Research methods
Patients who underwent surgical resection for a pathological identified SPN were included in this study. Patients were divided into 2 groups: PPM group and CM group. The baseline characteristics, intraoperative index, pathological outcomes, short-term complications and long-term follow-up data were compared between the 2 groups.
Research results
Patients with SPN had an excellent prognosis. PPM did not increase the surgical risks. After long-term follow-up, we identified PPM did not worsen the prognosis of patients with SPN. However, PPM is suitable for preserving the exocrine function of pancreas in young patients.
Research conclusions
PPM can be taken into consideration in SPN patients whose life expectancy is long.
Research perspectives
More multicenter prospective studies with large sample sizes are necessary to better understand the best surgical method for patients with SPN.
