Retrospective Study
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Feb 27, 2022; 14(2): 174-184
Published online Feb 27, 2022. doi: 10.4240/wjgs.v14.i2.174
Impact of parenchyma-preserving surgical methods on treating patients with solid pseudopapillary neoplasms: A retrospective study with a large sample size
Yu-Qiong Li, Shu-Bo Pan, Shu-Shu Yan, Zhen-Dong Jin, Hao-Jie Huang, Li-Qi Sun
Yu-Qiong Li, Shu-Bo Pan, Zhen-Dong Jin, Hao-Jie Huang, Li-Qi Sun, Department of Gastroenterology, Changhai Hospital, Shanghai 200433, China
Shu-Bo Pan, Department of Gastroenterology, Suzhou Science and Technology Town Hospital, Suzhou 215000, Jiangsu Province, China
Shu-Shu Yan, Department of Anesthesiology, Changhai Hospital, Shanghai 200433, China
Li-Qi Sun, Department of Gastroenterology, 72nd Group Army Hospital, Huzhou University, Huzhou 313000, Zhejiang Province, China
Author contributions: Li YQ, Pan SB and Yan SS contributed equally to this study and are co-first authors, were responsible for study design/planning, study conduct, data analysis and writing and revising the paper; Huang HJ and Sun LQ designed the study and they shared senior authorship; all authors have read and approve the final manuscript.
Institutional review board statement: The study was reviewed and approved by the Shanghai Changhai Hospital Ethics Committee (CHEC No. 2019-091).
Conflict-of-interest statement: The authors declare no conflicts of interest.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Qi Sun, MD, Assistant Professor, Department of Gastroenterology, Changhai Hospital, No. 168 Changhai Road, Yangpu District, Shanghai 200433, China. zjhzslqsmmu@qq.com
Received: October 7, 2021
Peer-review started: October 7, 2021
First decision: December 4, 2021
Revised: December 9, 2021
Accepted: January 25, 2022
Article in press: January 25, 2022
Published online: February 27, 2022
Processing time: 138 Days and 11.8 Hours
ARTICLE HIGHLIGHTS
Research background

Conventional surgical methods (CM) including pancreatoduodenectomy (PD), total pancreatectomy (TP) and distal pancreatectomy are standard surgical methods in the treatment of patients with Solid pseudopapillary neoplasm (SPN). CM is associated with a high rate of morbidity. However, the tumor mainly affects young women and the prognosis of the tumor is excellent.

Research motivation

The parenchyma-preserving surgical methods (PPM, including enucleation and central pancreatectomy ) are more and more often applied in clinical practice. The role of PPM in treating SPN remains clarified.

Research objectives

To evaluate the impact of PPM in the treatment of SPN patients.

Research methods

Patients who underwent surgical resection for a pathological identified SPN were included in this study. Patients were divided into 2 groups: PPM group and CM group. The baseline characteristics, intraoperative index, pathological outcomes, short-term complications and long-term follow-up data were compared between the 2 groups.

Research results

Patients with SPN had an excellent prognosis. PPM did not increase the surgical risks. After long-term follow-up, we identified PPM did not worsen the prognosis of patients with SPN. However, PPM is suitable for preserving the exocrine function of pancreas in young patients.

Research conclusions

PPM can be taken into consideration in SPN patients whose life expectancy is long.

Research perspectives

More multicenter prospective studies with large sample sizes are necessary to better understand the best surgical method for patients with SPN.