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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jul 27, 2021; 13(7): 689-701
Published online Jul 27, 2021. doi: 10.4240/wjgs.v13.i7.689
Novel parameter based on lipid indicators ratio improves prognostic value of plasma lipid levels in resectable colorectal cancer patients
Jun-Nan Gu, Shuang Yao, Ying-Hao Cao, Sheng-He Deng, Fu-Wei Mao, Hong-Yu Jiang, Yang-Ting He, Xin-Ying Li, Song-Qing Ke, Hui-Li Li, Hang Li, Xing-Hua Liu, Hong-Li Liu, Ji-Liang Wang, Ke Wu, Li Liu, Kai-Lin Cai
Jun-Nan Gu, Ying-Hao Cao, Sheng-He Deng, Fu-Wei Mao, Hui-Li Li, Hang Li, Xing-Hua Liu, Ji-Liang Wang, Ke Wu, Kai-Lin Cai, Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Shuang Yao, Hong-Yu Jiang, Yang-Ting He, Xin-Ying Li, Song-Qing Ke, Department of Epidemiology and Biostatistics, The Ministry of Education Key Lab of Environment and Health, School of Public Health, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Hong-Li Liu, Cancer Center, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Li Liu, Department of Epidemiology and Biostatistics, School of Public Health, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Gu JN was responsible for conceptualization, methodology, validation, and writing of the original draft; Yao S was responsible for conceptualization, methodology, software, and formal analysis; Cao YH, Deng SH, and Mao FW were responsible for investigation and resources; Jiang HY, He YT, Li XY, and Ke SQ were responsible for resources and data curation; Li HL was responsible for visualization, supervision, and manuscript writing, review, and editing; Li H and Liu XH were responsible for visualization and supervision; Liu HL, Wu K, and Wang JL were responsible for supervision and project administration; Liu L and Cai KL were responsible for manuscript writing, review, and editing, supervision, project administration, and funding acquisition, and should be regarded as co-corresponding authors.
Supported by the Graduates’ Innovation Fund, Huazhong University of Science and Technology, No. 2020yjsCXCY080; and the Free Innovation Pre-research Fund and Platform Scientific Research Fund in 2019, No. 02.03.2019-111.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of the Wuhan Union Hospital.
Informed consent statement: The analysis used clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this manuscript.
Data sharing statement: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Kai-Lin Cai, PhD, Doctor, Professor, Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Union Hospital, No. 1277 Jiefang Avenue, Jianghan District, Wuhan 430022, Hubei Province, China. caikailin@hust.edu.cn
Received: December 28, 2020
Peer-review started: December 28, 2020
First decision: February 23, 2021
Revised: March 11, 2021
Accepted: June 28, 2021
Article in press: June 28, 2021
Published online: July 27, 2021
ARTICLE HIGHLIGHTS
Research background
Abnormal lipid metabolism has been considered to be associated with the oncogenesis, development, and prognosis in cancer.
Research motivation
Although the association between abnormal lipid metabolism and cancer progression is widely recognized, the value of lipid indicators in evaluating the prognosis of colorectal cancer (CRC) is still relatively limited.
Research objectives
The present study aimed to evaluate the association between preoperative serum lipid conditions and the prognosis in patients with CRC.
Research methods
This study included 1696 colorectal cancer patients. Four key lipid factors and two lipid ratio indicators were calculated to analyze the association between these parameters and prognosis of CRC by Kaplan-Meier plot and Cox proportional hazards regression.
Research results
High-density lipoprotein cholesterol (HDL-C), apolipoprotein A1, HDL-C-low-density lipoprotein cholesterol ratio, and ApoA1-apolipoprotein B ratio were positively associated with the prognosis of CRC patients. Lipoprotein cholesterol-apolipoprotein (LA) score was independently associated with a good prognosis in resectable CRC patients.
Research conclusions
The current study indicated that serum lipid parameters, particularly the newly established LA score, might serve as candidate predictors of the prognosis of resectable CRC patients.
Research perspectives
We have identified the value of several lipid parameters and a newly constructed score in assessing the prognosis of resectable CRC patients in a retrospective study. Compared with more volatile inflammatory factors, these more stable lipid parameters can provide a great help to improve the prognostic evaluation of CRC.
