Feng J, Zhang HY, Yan L, Zhu ZM, Liang B, Wang PF, Zhao XQ, Chen YL. Feasibility and safety of “bridging” pancreaticogastrostomy for pancreatic trauma in Landrace pigs. World J Gastrointest Surg 2021; 13(5): 419-428 [PMID: 34122732 DOI: 10.4240/wjgs.v13.i5.419]
Corresponding Author of This Article
Yong-Liang Chen, MD, PhD, Director, Doctor, Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. chenyongl301@163.com
Research Domain of This Article
Surgery
Article-Type of This Article
Basic Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. May 27, 2021; 13(5): 419-428 Published online May 27, 2021. doi: 10.4240/wjgs.v13.i5.419
Feasibility and safety of “bridging” pancreaticogastrostomy for pancreatic trauma in Landrace pigs
Jian Feng, Hang-Yu Zhang, Li Yan, Zi-Man Zhu, Bin Liang, Peng-Fei Wang, Xiang-Qian Zhao, Yong-Liang Chen
Jian Feng, Department of Hepatopancreatobiliary Surgery, Peking University Shougang Hospital, Beijing 100144, China
Jian Feng, Hang-Yu Zhang, Li Yan, Zi-Man Zhu, Bin Liang, Peng-Fei Wang, Xiang-Qian Zhao, Yong-Liang Chen, Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China
Author contributions: Chen YL is the guarantor of the integrity of the entire study, carried out the study design, defined the intellectual content, participated in the literature research, and reviewed the manuscript; Feng J, Zhang HY, and Yan L performed the research, wrote the first draft, and analyzed the data; Zhu ZM, Liang B, Wang PF, and Zhao XQ assisted in animal experiments and acquired data; Zhang HY and Yan L are considered co-first author; All authors read and approved the final manuscript.
Institutional animal care and use committee statement: The operational procedures for the animal experiments were approved by the Institutional Animal Care and Use Committee (IACUC) of PLA General Hospital.
Conflict-of-interest statement: No conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the ARRIVE Guidelines, and the manuscript was prepared and revised according to the ARRIVE Guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Liang Chen, MD, PhD, Director, Doctor, Faculty of Hepato-Pancreato-Biliary Surgery, Institute of Hepatobiliary Surgery of Chinese PLA, Key Laboratory of Digital Hepetobiliary Surgery, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China. chenyongl301@163.com
Received: January 12, 2021 Peer-review started: January 12, 2021 First decision: February 14, 2021 Revised: February 19, 2021 Accepted: April 26, 2021 Article in press: April 26, 2021 Published online: May 27, 2021 Processing time: 126 Days and 13 Hours
ARTICLE HIGHLIGHTS
Research background
In recent years, a new anastomosis method, “bridging” pancreaticogastrostomy, to treat patients with an extremely severe pancreatic injury was created and employed. This surgery has advantages such as short length of surgery, low secondary trauma, rapid construction of shunts for pancreatic fluid, preventing second surgeries, and achieving good treatment outcomes in clinical practice.
Research motivation
There is a lack of strong evidence to support the feasibility and safety of this surgical procedure. We carried out an animal experiment to examine this procedure.
Research objectives
This study aimed to examine the feasibility and safety of a new rapid method of pancreaticogastrostomy, “bridging” pancreaticogastrostomy.
Research methods
In total, 10 Landrace pigs were randomized into the experimental and control groups. “Bridging” pancreaticogastrostomy was performed in the experimental group, while routine mucosa-to-mucosa pancreaticogastrostomy was performed in the control group. The resurgery was carried out at 1 and 6 mo after the first surgery to examine the condition of the abdominal cavity and firmness and tightness of the pancreaticogastric anastomosis and pancreas.
Research results
One animal in the control group did not gain weight 6 mo after surgery, whereas significant weight gain was present in the others. There were significant differences on Days 1 and 3 after surgery between the two groups but no differences on Days 5 and 7. One month after surgery, the sinus tract orifice/anastomosis was patent in the two groups. Six months after surgery, the sinus tract orifice/anastomosis was sealed, and pancreases in both groups presented with chronic pancreatitis.
Research conclusions
"Bridging" pancreaticogastrostomy is completely feasible as a means of damage control surgery during the early stage of pancreatic injury.
Research perspectives
“Bridging” pancreaticogastrostomy can be used to establish rapidly a channel and has similar short- and long-term results as conventional pancreaticogastrostomy.
