Liang TS, Zhang BL, Zhao BB, Yang DG. Low serum albumin may predict poor efficacy in patients with perforated peptic ulcer treated nonoperatively. World J Gastrointest Surg 2021; 13(10): 1226-1234 [PMID: 34754390 DOI: 10.4240/wjgs.v13.i10.1226]
Corresponding Author of This Article
Bao-Lei Zhang, MD, Attending Doctor, Department of Gastrointestinal Surgery, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Dongchangfu District, Liaocheng 252000, Shandong Province, China. wohaishilaohu@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Oct 27, 2021; 13(10): 1226-1234 Published online Oct 27, 2021. doi: 10.4240/wjgs.v13.i10.1226
Low serum albumin may predict poor efficacy in patients with perforated peptic ulcer treated nonoperatively
Tang-Shuai Liang, Bao-Lei Zhang, Bing-Bo Zhao, Dao-Gui Yang
Tang-Shuai Liang, Bao-Lei Zhang, Bing-Bo Zhao, Dao-Gui Yang, Department of Gastrointestinal Surgery, Liaocheng People’s Hospital, Liaocheng 252000, Shandong Province, China
Author contributions: Liang TS and Yang DG were responsible for designing the study and reviewing the manuscript; Liang TS and Zhang BL drafted the manuscript; Liang TS and Zhao BB collected the clinical data and abstracted the data; Liang TS and Zhang BL were responsible for revising the manuscript; All authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of Liaocheng People’s Hospital.
Informed consent statement: As this is a retrospective study, signed informed consent was unnecessary.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Bao-Lei Zhang, MD, Attending Doctor, Department of Gastrointestinal Surgery, Liaocheng People’s Hospital, No. 67 Dongchang West Road, Dongchangfu District, Liaocheng 252000, Shandong Province, China. wohaishilaohu@163.com
Received: March 20, 2021 Peer-review started: March 20, 2021 First decision: June 3, 2021 Revised: June 15, 2021 Accepted: August 16, 2021 Article in press: August 16, 2021 Published online: October 27, 2021 Processing time: 220 Days and 2.8 Hours
ARTICLE HIGHLIGHTS
Research background
Nonoperative management (NOM) is a promising therapeutic modality for patients with perforated peptic ulcer (PPU). However, the risk factors for poor efficacy and adverse events of NOM are a concern.
Research motivation
Prognostic factors that could enhance recovery, and reduce morbidity and mortality should be identified and investigated further in patients with PPU.
Research objectives
The aim of this study was to evaluate the relationship between risk factors and clinical outcome, and identify which factors can be used for risk stratification in patients with PPU.
Research methods
Total 272 patients who were diagnosed with PPU and initially managed nonoperatively from January 2014 to December 2018 were enrolled. The clinical data of these patients were collected. Baseline patient characteristics and adverse outcomes were compared between the two groups.
Research results
Multivariate analyses revealed that low serum albumin level was an independent predictor for poor efficacy of NOM and adverse outcomes in patients with PPU.
Research conclusions
Low serum albumin level may be used as an indicator to help us predict poor efficacy of NOM and adverse outcomes, and can be used for risk stratification in patients with PPU.
Research perspectives
Low serum albumin is an independent risk factor that may predict adverse consequences of NOM for PPU.
