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©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Onodera's Prognostic Nutritional Index is a novel and useful prognostic marker for gastrointestinal stromal tumors
Hao Wang, Ying-Ying Xu, Jun You, Wen-Qing Hu, Shao-Feng Wang, Ping Chen, Fan Yang, Lei Shi, Wei Zhao, Liang Zong
Hao Wang, Ping Chen, Lei Shi, Wei Zhao, Department of Gastrointestinal Surgery, Northern Jiangsu People’s Hospital, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
Ying-Ying Xu, Department of General Surgery, Yizheng People’s Hospital, Clinical Medical College, Yangzhou University, Yangzhou 211400, Jiangsu Province, China
Jun You, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Xiamen University, Teaching Hospital of Fujian Medical University, Xiamen 361005, Fujian Province, China
Wen-Qing Hu, Liang Zong, Department of Gastrointestinal Surgery, Changzhi People’s Hospital, The Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Shao-Feng Wang, Department of Digestive Internal Medicine, Changzhi People’s Hospital, The Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Fan Yang, Department of Central Laboratory, Changzhi People’s Hospital, The Affiliated Hospital of Changzhi Medical College, Changzhi 046000, Shanxi Province, China
Author contributions: Xu YY, Wang H, and Zong L designed the research; Wang H, You J, Hu WQ, Wang SF, and Chen P performed the research; Shi L, Yang F, and Zhao W analyzed the data; Xu YY and Wang H wrote the paper and contributed equally to this study.
Supported by Health Commission of Shanxi Province, No. 2020130 and No. 2020TD27; and the Science and Technology Planning Project of Yangzhou City, No. YZ2018092.
Institutional review board statement: This study was approved by the Ethics Committee of Northern Jiangsu People’s Hospital.
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: We have no financial relationships to disclose.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
http://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Liang Zong, MD, PhD, Professor, Research Associate, Department of Gastrointestinal Surgery, Changzhi People’s Hospital, The Affiliated Hospital of Changzhi Medical College, No. 502 Changxing Middle Road, Luzhou District, Changzhi 046000, Shanxi Province, China. 250537471@qq.com
Received: March 18, 2021
Peer-review started: March 18, 2021
First decision: June 3, 2021
Revised: June 17, 2021
Accepted: August 13, 2021
Article in press: August 13, 2021
Published online: October 27, 2021
ARTICLE HIGHLIGHTS
Research background
Prognostic markers have gained considerable attention in gastrointestinal stromal tumors (GISTs).
Research motivation
To improve the prognostic prediction of GISTs, we designed this study.
Research objectives
We conducted the first investigation of the prognostic value of Onodera’s Prognostic Nutritional Index (OPNI) for GISTs.
Research methods
In this study, the recurrence-free survival, and the receiver operator characteristic analysis of neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR), OPNI, and Ki-67 index, and the correlation between tumor size and NLR, PLR, OPNI and Ki-67 index were detected.
Research results
Univariate and multivariate analyses both identified the OPNI as an independent prognostic marker.
Research conclusions
The preoperative OPNI could be a prognostic marker for GISTs.
Research perspectives
We hope that we could find a valuable parameter for predicting the prognosis of GISTs using peripheral blood samples.
