Published online Jun 27, 2020. doi: 10.4240/wjgs.v12.i6.269
Peer-review started: December 15, 2019
First decision: April 2, 2020
Revised: April 10, 2020
Accepted: May 5, 2020
Article in press: May 5, 2020
Published online: June 27, 2020
Processing time: 186 Days and 11.7 Hours
It has been suggested that some micronutrients would have antioxidant potential and could reduce the accumulation of reactive oxygen species, consequently delaying or preventing the evolution of nonalcoholic fatty liver disease (NAFLD).
Identify potential new therapeutic strategies for NAFLD.
Evaluate the relationship between serum levels of micronutrients and the severity of NAFLD.
A retrospective, observational, and cross-sectional study was conducted. This study included patients undergoing bariatric surgery at a reference center in southern Brazil. These patients underwent liver biopsy during the procedure and had serum levels of micronutrients assessed in a preoperative evaluation.
Serum levels of vitamin D were negatively correlated with the severity of steatosis and nonalcoholic steatohepatitis, and serum levels of vitamin B12 were positively correlated with the severity of steatosis and fibrosis.
Serum levels of vitamin D are inversely related to the severity of steatosis and nonalcoholic steatohepatitis, and serum levels of vitamin B12 are higher in more advanced stages of simple steatosis and liver fibrosis.
Further studies should be done to assess the relationship of micronutrients and NAFLD.