Egorov VI, Kharazov AF, Pavlovskaya AI, Petrov RV, Starostina NS, Kondratiev EV, Filippova EM. Extensive multiarterial resection attending total duodenopancreatectomy and adrenalectomy for MEN-1-associated neuroendocrine carcinomas. World J Gastrointest Surg 2012; 4(10): 238-245 [PMID: 23443490 DOI: 10.4240/wjgs.v4.i10.238]
Corresponding Author of This Article
Dr. Vyacheslav Ivanovich Egorov, Sechenov First State Medical University, Ostroumov 14th City Hospital, Department of Surgical Oncology, 117997 Moscow, Russia. v.egorov61@gmail.com
Article-Type of This Article
Case Report
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World J Gastrointest Surg. Oct 27, 2012; 4(10): 238-245 Published online Oct 27, 2012. doi: 10.4240/wjgs.v4.i10.238
Extensive multiarterial resection attending total duodenopancreatectomy and adrenalectomy for MEN-1-associated neuroendocrine carcinomas
Vyacheslav Ivanovich Egorov, Alexander Felixovich Kharazov, Alla Ivanovna Pavlovskaya, Roman Valeryevich Petrov, Natalia Sergeevna Starostina, Eugeny Valerievich Kondratiev, Ekaterina Mikhailovna Filippova
Vyacheslav Ivanovich Egorov, Sechenov First State Medical University, Ostroumov 14th City Hospital, Department of Surgical Oncology, 117997 Moscow, Russia
Alexander Felixovich Kharazov, Department of Vascular Surgery, Vishnevsky Institute of Surgery, 117997 Moscow, Russia
Alla Ivanovna Pavlovskaya, Department of Pathology, Blokhin Cancer Research Centre Moscow, 117997 Moscow, Russia
Roman Valeryevich Petrov, Russiaogov Russian National Research Medical University, General Surgery Department, 117997 Moscow, Russia
Natalia Sergeevna Starostina, Eugeny Valerievich Kondratiev, Department of Radiology, Vishnevsky Institute of Surgery, 117997 Moscow, Russia
Ekaterina Mikhailovna Filippova, Department of Pathology, Vishnevsky Institute of Surgery, 117997 Moscow, Russia
Author contributions: Egorov VI made principal conceptual contributions and designed the case report; Egorov VI, Kharazov AF and Petrov RV made contributions to primary surgery; Starostina NS and Kondratiev EV performed radiology imaging and reporting; Filippova EM and Pavlovskaya AI carried out the pathology investigations and reports; all authors contributed to data acquisition and interpretation, literature research, drafting the manuscript, revision and final version approval.
Correspondence to: Dr. Vyacheslav Ivanovich Egorov, Sechenov First State Medical University, Ostroumov 14th City Hospital, Department of Surgical Oncology, 117997 Moscow, Russia. v.egorov61@gmail.com
Telephone: +7-495-2379226 Fax: +7-495-2366130
Received: June 25, 2012 Revised: September 11, 2012 Accepted: October 20, 2012 Published online: October 27, 2012
Abstract
Pancreatic neuroendocrine tumors (PNTs) are relatively uncommon although these neoplasms have been noted to grow in occurrence in recent decades. Surgical removal of locally advanced PNTs involving major vessels and adjacent organs is warranted by reason of an appreciably more favorable prognosis as compared to exocrine pancreas cancer. We are reporting a case of successful multi-organ resection combined with a wide excision of the superior mesenteric, common, proper, left and right hepatic arteries (in the presence of the hepatomesenteric trunk variant of aberrant arterial anatomy) for multifocal PNTs in the setting of multiple neuroendocrine neoplasia type 1 syndrome. The procedure resulted in pain abolition, a significant improvement in the patient’s life quality and allowed her to return to work. Follow-up computed tomography at 15 mo post-surgery showed no evidence of disease recurrence.
