Tang QY, Yu W. Logistic regression analysis of pathological features of bone metastasis in colorectal cancer and related influencing factors after surgery. World J Gastrointest Surg 2025; 17(4): 100851 [DOI: 10.4240/wjgs.v17.i4.100851]
Corresponding Author of This Article
Wei Yu, Department of Orthopedics, Jiujiang First People’s Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi Province, China. 18879230086@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Cohort Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2025; 17(4): 100851 Published online Apr 27, 2025. doi: 10.4240/wjgs.v17.i4.100851
Logistic regression analysis of pathological features of bone metastasis in colorectal cancer and related influencing factors after surgery
Qiu-Yan Tang, Wei Yu
Qiu-Yan Tang, The First Department of Oncology, Jiujiang First People’s Hospital, Jiujiang 332000, Jiangxi Province, China
Wei Yu, Department of Orthopedics, Jiujiang First People’s Hospital, Jiujiang 332000, Jiangxi Province, China
Author contributions: Tang QY designed the study; Tang QY and Yu W contributed to the analysis of the data and writing of this article; and both authors have read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Institutional Review Board of Jiujiang First People’s Hospital (No. JJDYRMYY202304X).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The authors declare no conflicts of interest.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wei Yu, Department of Orthopedics, Jiujiang First People’s Hospital, No. 48 Taling South Road, Xunyang District, Jiujiang 332000, Jiangxi Province, China. 18879230086@163.com
Received: December 27, 2024 Revised: January 23, 2025 Accepted: February 18, 2025 Published online: April 27, 2025 Processing time: 91 Days and 23.4 Hours
Abstract
BACKGROUND
Colorectal cancer (CRC) is a common malignant tumor in the digestive system, whose main treatment comprises surgical resection, radiotherapy and chemotherapy, and targeted drug therapy. At present, the radical resection of CRC is the main way of achieving an early cure.
AIM
To investigate the logistic regression analysis of bone metastasis after CRC surgery and related influencing factors.
METHODS
We selected 100 patients who underwent surgery for CRC and were admitted from February 2018 to February 2024, collected the general data of bone metastasis, and collected the pathological characteristics of patients with bone metastasis. Next, we divided them into groups with and without bone metastasis (Bone metastases group, n = 44; no bone metastases group, n = 56), compared the clinical data of the two groups, and analyzed the risk factors of bone metastasis using logistic regression analysis.
RESULTS
Among the 100 patients, the mean age was 54.33 ± 8.45 years, and most were male (54.55%). The proportion of patients with lytic bone changes was 43.18%. The most common location of combined bone metastasis was the pelvis, whereas only 5 patients had limb transfer. There was a higher incidence of lung than of pancreatic or liver metastases. Regression analysis showed that the primary location of the cancer was rectal cancer. Lymph node involvement, lung metastasis, and no postoperative chemotherapy were the risk factors for postoperative bone metastasis in patients who underwent surgery for CRC (P < 0.05).
CONCLUSION
Rectal cancer, lymph node involvement, complicated pulmonary metastasis, and no postoperative chemotherapy treatment can help predict high risk of bone metastasis in CRC.
Core Tip: Early identification of bone metastasis risk in colorectal cancer patients is critical, especially pre- and post-surgery. Targeted interventions for risk factors are essential. These may include bone-protecting drugs, dietary improvements, and exercise to boost bone health. Regular monitoring through imaging and tests helps detect early signs of bone metastasis, allowing for timely treatment and improved patient outcomes.
