Zhong FH. Personalized nutritional care for immune function recovery in postoperative gastrointestinal surgery patients: An observational study. World J Gastrointest Surg 2025; 17(2): 99893 [DOI: 10.4240/wjgs.v17.i2.99893]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2025; 17(2): 99893 Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.99893
Personalized nutritional care for immune function recovery in postoperative gastrointestinal surgery patients: An observational study
Fang-Hong Zhong
Fang-Hong Zhong, Department of Clinical Nutrition, Ganzhou People's Hospital, Ganzhou 341000, Jiangxi Province, China
Author contributions: Zhong FH conceptualized this study, collected data, drafted the initial draft, and contributed to formal analysis; Zhong FH provided guidance for this study, contributing to its methodology and visualization; Zhong FH validated the study and edited the manuscript.
Institutional review board statement: This study has been reviewed and approved by the Medical Ethics Committee of Ganzhou People's Hospital with approval number 2021BL-045-01.
Informed consent statement: Informed consent was obtained from all patients and their guardians, with signed consent forms.
Conflict-of-interest statement: The author declares no potential conflicts of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: October 23, 2024 Revised: November 18, 2024 Accepted: December 16, 2024 Published online: February 27, 2025 Processing time: 90 Days and 23.6 Hours
Abstract
BACKGROUND
Gastrointestinal (GI) surgery can significantly affect the nutritional status and immune function of patients. This study aimed to investigate the effects of personalized nutritional care on the recovery of immune function in patients who underwent postoperative GI surgery.
AIM
To study examines personalized nutritional care’s impact on immune function recovery, nutritional status, and clinical outcomes after GI surgery.
METHODS
This observational study included 80 patients who underwent GI surgery between 2021 and 2023. Patients received personalized nutritional care based on their individual needs and surgical outcomes. Immune function markers including lymphocyte subsets, immunoglobulins, and cytokines were measured preoperatively and at regular intervals postoperatively. Nutritional status, clinical outcomes, and quality of life were assessed.
RESULTS
Patients receiving personalized nutritional care showed significant improvements in immune function markers compared to baseline. At 4 weeks postoperatively, CD4+ T-cell counts increased by 25% (P < 0.001), while interleukin-6 levels decreased by 40% (P < 0.001). Nutritional status, as measured by prealbumin and transferrin levels, improved by 30% (P < 0.01). Postoperative complications reduced by 35% compared to historical controls. The quality-of-life scores improved by 40% at 3 months postoperatively.
CONCLUSION
Personalized nutritional care enhances immune function recovery, improves nutritional status, and reduces complications in patients undergoing postoperative GI surgery, highlighting its crucial role in optimizing patient outcomes following such procedures.
Core Tip: This study explored the effect of personalized nutritional care on the recovery of immune function in patients who underwent postoperative gastrointestinal (GI) surgery. These findings demonstrate significant improvements in immune function markers, nutritional status, and quality of life (QoL) among patients receiving personalized nutritional interventions. Specifically, there was an increase in CD4+ T-cell counts, decrease in interleukin-6 levels, reduction in postoperative complications, and enhanced QoL scores. This study underscores the importance of tailored nutritional interventions based on individual patient needs, optimizing outcomes following GI surgery.
