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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Magnamosis for rectal reconstruction in canines
Shi-Qi Liu, Hong-Ke Zhang, Yi Lv, Xiang-Hua Xu, Yu-Feng Li, Dong-Wen Quan
Shi-Qi Liu, Medical College, Xijing University, Xi’an 710123, Shaanxi Province, China
Hong-Ke Zhang, Department of Pediatric Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Hong-Ke Zhang, Yi Lv, Xiang-Hua Xu, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Xi’an 710061, Shaanxi Province, China
Yi Lv, Xiang-Hua Xu, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Yu-Feng Li, Department of Pediatric Surgery, Guilin Maternal and Child Health Hospital, Guilin 541001, Guangxi Zhuang Autonomous Region, China
Dong-Wen Quan, The Second Clinical Medical School, Shaanxi University of Chinese Medicine, Xianyang 712000, Shaanxi Province, China
Co-corresponding authors: Yi Lv and Yu-Feng Li.
Author contributions: Liu SQ conducted the study design, operated the study and drafted this manuscript; Zhang HK and Quan DW collected and analyzed the data. Xu XH contributed to the perioperative management and data collection; Lv Y and Li YF guided and revised the manuscript; Lv Y and Li YF are listed as co-corresponding authors for three reasons: Firstly, this is an interdisciplinary study merging magnetic medicine and neonatal surgery that requires the guidance of seasoned professionals from both disciplines; Secondly, Lv Y, an authority in magnetic medicine, exerted a crucial role in the design of the device delineated in this article, whereas Li YF, a highly experienced pediatric surgeon, played an equally important role in surgical guidance; Thirdly, throughout the entire experimental process and manuscript writing, Lv Y and Li YF provided highly professional insights in the manuscript. In summary, listing Li YF and Lv Y as co-corresponding authors has been agreed by all members of our team, and is also in line with the principle of equal contribution and cooperation.
Supported by National Natural Science Foundation of China, No. 82170676; Natural Science Foundation of Shaanxi Provincial Key Industries Innovation Chain (Cluster)-Social Development Project, No. 2020ZDLSF02-03; and Xi'an Talents Plan Project, No. XAYC210064.
Institutional animal care and use committee statement: This study was approved by the Ethics Committee for Animal Experiments of Xi’an Jiaotong University Health Science Center (No. 2021-302).
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No additional data are available.
ARRIVE guidelines statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Yi Lv, PhD, Professor, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China.
luyi169@126.com
Received: June 11, 2024
Revised: October 25, 2024
Accepted: December 3, 2024
Published online: February 27, 2025
Processing time: 225 Days and 0.5 Hours
BACKGROUND
The magnamosis, a minimal invasive, suture-free procedure, has been used for digestive tract or vessel reconstruction, such as gastrointestinal anastomosis, bilioenteric anastomosis, and coronary artery bypass. Although some case reports have demonstrated the potential of magnamosis for the treatment of congenital rectal atresia (RA), they cannot provide strong evidence for its widespread application.
AIM
To assess the feasibility and safety of magnamosis in treating RA in dogs as compared to suturing anastomosis. The findings of this study can be beneficial in guiding the clinical application of magnamosis.
METHODS
Thirty-six dogs were randomly assigned to the magnamosis group (n =18) and the suturing anastomosis group (n =18). The rectum was freed laparoscopically in all dogs. In the magnamosis group, rectal anastomosis was performed using a pair of magnetic rings, while the suturing anastomosis group underwent a straight-sighted end-to-end rectal anastomosis with 4-0 absorbable sutures. The anastomosis time was recorded, and abdominal plain film examination was performed to locate the magnets until they were expelled postoperatively. Specimens of the anastomosis were evaluated at one month, three months, and six months after surgery.
RESULTS
The mean time for rectal anastomosis was significantly shorter in the magnamosis group (12.22 ± 2.78 minutes) than the suturing anastomosis group (18.11 ± 1.68 minutes). There was one incidence of anastomotic bleeding in the suturing anastomosis group, whereas no complication was recorded in the magnamosis group. The magnets were discharged post-surgery in 7.17 ± 1.30 days in all the dogs. The histopathological examination revealed a smoother healing of anastomotic mucosa in the magnamosis group as compared to that in the suturing anastomosis group. Moreover, the fiber alignment was also more natural in the magnamosis group with minimal inflammation.
CONCLUSION
Rectal reconstruction using magnamosis is a feasible, safe, and effective alternative to suturing anastomosis in dogs, with the added benefit of faster and more natural healing of the anastomosis.
Core Tip: Magnamosis is a very new and effective method for treating rectal atresia in clinical, it can effectively avoid the extensive iatrogenic injury of pelvic floor muscle and nerve plexus caused by Pena operation. This is a very promising clinical innovation technology and method. At present, although there are a few clinical applications of magnetic rectal anastomosis papers, but the basic experiments of magnetic rectal anastomosis animals are blank. This study shows that rectal reconstruction using magnamosis is a feasible, safe, and effective alternative to suturing anastomosis in dogs, with the added benefit of faster and more natural healing of the anastomosis.
