Ding QZ, Wang RL, Xie Y. Unmasking gastric carcinoma: Unveiling diagnostic biomarkers and the role of critical care. World J Gastrointest Surg 2025; 17(2): 102444 [DOI: 10.4240/wjgs.v17.i2.102444]
Corresponding Author of This Article
Yun Xie, MD, Associate Chief Physician, Intensive Care Unit, Shanghai General Hospital, No. 650 New Songjiang Road, Shanghai 201600, China. 772723513@qq.com
Research Domain of This Article
Critical Care Medicine
Article-Type of This Article
Letter to the Editor
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2025; 17(2): 102444 Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.102444
Unmasking gastric carcinoma: Unveiling diagnostic biomarkers and the role of critical care
Qun-Zhe Ding, Rui-Lan Wang, Yun Xie
Qun-Zhe Ding, School of Information Management, Wuhan University, Wuhan 430072, Hubei Province, China
Rui-Lan Wang, Yun Xie, Intensive Care Unit, Shanghai General Hospital, Shanghai 201600, China
Co-corresponding authors: Rui-Lan Wang and Yun Xie.
Author contributions: Ding QZ contributed to methodology, formal analysis, writing- original draft; Xie Y and Wang RL contributed to conceptualization, methodology, supervision, writing-review and editing.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun Xie, MD, Associate Chief Physician, Intensive Care Unit, Shanghai General Hospital, No. 650 New Songjiang Road, Shanghai 201600, China. 772723513@qq.com
Received: October 18, 2024 Revised: November 16, 2024 Accepted: December 4, 2024 Published online: February 27, 2025 Processing time: 96 Days and 21.4 Hours
Abstract
We discuss the findings of Wu et al on the utility of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index as diagnostic markers for gastric carcinoma (GC). We commend the study's contributions to the field and suggest a prospective study to validate these markers' sensitivity and specificity for early GC detection. We also propose developing surveillance protocols that incorporate these markers with other diagnostic methods to enhance clinical decision-making. Furthermore, we highlight the need for a more diverse patient cohort to assess the generalizability of these markers across different ethnic groups and demographic factors. Our suggestions aim to refine the application of these markers in clinical practice and to understand their potential in diverse clinical scenarios.
Core Tip: This commentary highlights the potential of using neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and systemic immune-inflammatory index as cost-effective early diagnostic markers for gastric carcinoma, emphasizing their significance in critical care and the need for further research to incorporate these markers into a multi-modal diagnostic approach for improved patient outcomes.
