Xu DJ, Wang GT, Zhong Q. Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy. World J Gastrointest Surg 2025; 17(2): 100034 [DOI: 10.4240/wjgs.v17.i2.100034]
Corresponding Author of This Article
Dao-Jian Xu, Assistant Professor, MD, Department of Emergency Medicine, Taizhou Municipal Hospital, No. 381 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. jjxudaojian@163.com
Research Domain of This Article
Emergency Medicine
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2025; 17(2): 100034 Published online Feb 27, 2025. doi: 10.4240/wjgs.v17.i2.100034
Extracellular matrix gene set and microRNA network in intestinal ischemia-reperfusion injury: Insights from RNA sequencing for diagnosis and therapy
Dao-Jian Xu, Guo-Tao Wang, Qiang Zhong
Dao-Jian Xu, Guo-Tao Wang, Qiang Zhong, Department of Emergency Medicine, Taizhou Municipal Hospital, Taizhou 318000, Zhejiang Province, China
Author contributions: Xu DJ wrote the original draft; Wang GT and Zhong Q conceptualized, wrote, reviewed, and edited the manuscript. All authors participated in drafting the manuscript and all have read, contributed to, and approved the final version of the manuscript.
Supported by Health Science and Technology Programme of Zhejiang Province, No. 2022KY1391.
Conflict-of-interest statement: Every author has stated that there is no commercial, professional, or personal conflict of interest relevant to the study, proving that it complies with the principles of publishing ethics.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dao-Jian Xu, Assistant Professor, MD, Department of Emergency Medicine, Taizhou Municipal Hospital, No. 381 Zhongshan East Road, Jiaojiang District, Taizhou 318000, Zhejiang Province, China. jjxudaojian@163.com
Received: August 5, 2024 Revised: November 26, 2024 Accepted: December 6, 2024 Published online: February 27, 2025 Processing time: 169 Days and 17.1 Hours
Abstract
Intestinal ischemia-reperfusion injury (IIRI) is a complex and severe pathophysiological process characterized by oxidative stress, inflammation, and apoptosis. In recent years, the critical roles of extracellular matrix (ECM) genes and microRNAs (miRNAs) in IIRI have garnered widespread attention. This review aims to systematically summarize the diagnostic and therapeutic potential of ECM gene sets and miRNA regulatory networks in IIRI. First, we review the molecular mechanisms of IIRI, focusing on the dual role of the ECM in tissue injury and repair processes. The expression changes and functions of ECM components such as collagen, elastin, and matrix metalloproteinases during IIRI progression are deeply analyzed. Second, we systematically summarize the regulatory roles of miRNAs in IIRI, particularly the mechanisms and functions of miRNAs such as miR-125b and miR-200a in regulating inflammation, apoptosis, and ECM remodeling. Additionally, this review discusses potential diagnostic biomarkers and treatment strategies based on ECM genes and miRNAs. We extensively evaluate the prospects of miRNA-targeted therapy and ECM component modulation in preventing and treating IIRI, emphasizing the clinical translational potential of these emerging therapies. In conclusion, the diagnostic and therapeutic potential of ECM gene sets and miRNA regulatory networks in IIRI provides new directions for further research, necessitating additional clinical and basic studies to validate and expand these findings for improving clinical outcomes in IIRI patients.
Core Tip: This review systematically summarizes the diagnostic and therapeutic potential of extracellular matrix (ECM) gene sets and microRNA (miRNA) regulatory networks in intestinal ischemia-reperfusion injury (IIRI). We review the critical roles of the ECM in the pathological processes of IIRI and discuss the mechanisms by which specific miRNAs regulate inflammation, apoptosis, and ECM remodeling. Based on these molecular insights, potential diagnostic biomarkers and treatment strategies, including miRNA-targeted therapy and ECM component modulation, demonstrate significant clinical translational prospects. In summary, the roles of ECM genes and miRNAs in IIRI provide new research directions aimed at improving patient diagnosis and treatment outcomes.
