Zhang YH, Ma C, Huang XM, Liu Y. Influence factors of clinical effects on patients with early gastric cancer: A retrospective study. World J Gastrointest Surg 2025; 17(1): 94873 [PMID: 39872760 DOI: 10.4240/wjgs.v17.i1.94873]
Corresponding Author of This Article
Yang Liu, Associate Chief Physician, Digestive Endoscopy Center, Chonggang General Hospital, No. 1 Dayan Sancun Road, Dadukou District, Chongqing 400080, China. cqliuyang008@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jan 27, 2025; 17(1): 94873 Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.94873
Influence factors of clinical effects on patients with early gastric cancer: A retrospective study
Yong-Hua Zhang, Chao Ma, Xiao-Mei Huang, Yang Liu
Yong-Hua Zhang, Chao Ma, Department of General Surgery, Chonggang General Hospital, Chongqing 400080, China
Xiao-Mei Huang, Department of Gastroenterology, Chonggang General Hospital, Chongqing 400080, China
Yang Liu, Digestive Endoscopy Center, Chonggang General Hospital, Chongqing 400080, China
Author contributions: Liu Y carried out the study design and manuscript revision; Zhang YH and Ma C collected data and investigated the manuscript; Liu Y, Zhang YH, and Ma C drafted and analyzed the manuscript; Zhang YH, Ma C, and Huang XM investigated the manuscript; Huang XM edited the manuscript; and all authors read and approved the final version of the manuscript.
Institutional review board statement: This study protocol was reviewed and approved by the ethic committee of the Chonggang General Hospital, approval No. 2024-SY-11.
Informed consent statement: Since this study is a retrospective study and the identification information of patients has anonymity, there is no need for informed consent from patients and their families.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: All data generated or analyzed in this study are included in the present manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yang Liu, Associate Chief Physician, Digestive Endoscopy Center, Chonggang General Hospital, No. 1 Dayan Sancun Road, Dadukou District, Chongqing 400080, China. cqliuyang008@163.com
Received: March 27, 2024 Revised: October 14, 2024 Accepted: November 1, 2024 Published online: January 27, 2025 Processing time: 275 Days and 11.8 Hours
Abstract
BACKGROUND
Identifying factors that influence non-curative resection (NCR) is critical to optimize treatment strategies and improve patient outcomes in patients with early gastric cancer (EGC).
AIM
To investigate the factors influencing the NCR of EGC and to evaluate the predictive value of these factors.
METHODS
The clinical data of 173 patients with EGC admitted between July 2020 and July 2023 were retrospectively collected. According to radical resection criteria, the patients were further divided into curative resection group (n = 143) and NCR group (n = 30). Clinical information was collected, including surgical method, tumor diameter, tumor site, ulcer formation, depth of invasion, pathological type, and lymph node metastasis. Logistic regression analysis was used to explore the factors affecting non-curable resection.
RESULTS
Multivariate logistic regression analysis showed that ulcer formation [odds ratio (OR) = 3.53; 95% confidence interval (CI): 1.55-8.01, P = 0.003], pathological type (OR = 3.73; 95%CI: 1.60-8.74, P = 0.002), tumor diameter (OR = 3.15; 95%CI: 1.40-7.05, P = 0.005), tumor location (OR = 3.50; 95%CI: 1.16-10.58, P = 0.027), lymph node metastasis (OR = 4.40; 95%CI: 1.83-10.57, P = 0.001), and depth of penetration (OR = 3.75; 95%CI: 1.60-8.74, P = 0.002) were all risk factors for NCR in EGC patients. Predictive analysis showed varying area under the curve values for factors such as tumor diameter (0.636), tumor location (0.608), ulcer formation (0.652), infiltration depth (0.658), pathological type (0.656), and lymph node metastasis (0.674).
CONCLUSION
The results suggest that factors such as tumor diameter, tumor location, ulcer formation, depth of invasion, pathological type, and lymph node metastasis increase the risk of NCR in EGC patients.
Core Tip: In order to identify factors influencing non-curative resection (NCR) in patients with early gastric cancer (EGC) and assess the predictive value of these factors, a retrospective analysis was conducted on 173 EGC patients between July 2020 and July 2023. The cohort was stratified into two groups: Curative resection group (143 cases) and NCR group (30 cases) based on adherence to curative resection guidelines. Various risk factors were systematically documented and analyzed. The findings underscored that tumor diameter, location, ulceration, infiltration depth, pathological classification, and lymph node metastasis emerged as pivotal risk determinants for NCR in individuals with EGC.
