Wu SJ, Wu CY, Ye K. Risk factors, monitoring, and treatment strategies for early recurrence after rectal cancer surgery. World J Gastrointest Surg 2025; 17(1): 100232 [PMID: 39872795 DOI: 10.4240/wjgs.v17.i1.100232]
Corresponding Author of This Article
Kai Ye, MD, Chief Doctor, Dean, Professor, Research Dean, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou 362000, Fujian Province, China. medwcy@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Editorial
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jan 27, 2025; 17(1): 100232 Published online Jan 27, 2025. doi: 10.4240/wjgs.v17.i1.100232
Risk factors, monitoring, and treatment strategies for early recurrence after rectal cancer surgery
Si-Jia Wu, Chu-Ying Wu, Kai Ye
Si-Jia Wu, Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Chu-Ying Wu, Kai Ye, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, Fujian Province, China
Co-first authors: Si-Jia Wu and Chu-Ying Wu.
Author contributions: Wu SJ and Wu CY contributed equally to the study as co-first authors; Wu SJ contributed to original draft preparation, writing, and review; Wu CY contributed to writing, review, and editing; Ye K contributed to conceptualization, supervision, and funding acquisition; all authors have read and agreed to the published version of the manuscript.
Supported by the Key Clinical Specialty Discipline Construction Program of Fujian, Fujian Health Medicine and Politics, No. [2022]884.
Conflict-of-interest statement: All authors report no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Kai Ye, MD, Chief Doctor, Dean, Professor, Research Dean, Surgeon, Surgical Oncologist, Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Fujian Medical University, No. 950 Donghai Street, Quanzhou 362000, Fujian Province, China. medwcy@163.com
Received: August 10, 2024 Revised: November 23, 2024 Accepted: November 29, 2024 Published online: January 27, 2025 Processing time: 139 Days and 1 Hours
Abstract
Early recurrence (ER) following surgery for rectal cancer is a significant factor impacting patient survival rates. Tsai et al identified age, preoperative neoadjuvant therapy, length of hospital stay, tumour location, and pathological stage as factors influencing the risk of ER. Postoperative monitoring for ER should encompass a thorough medical history review, physical examination, tumour marker testing, and imaging studies. Additionally, noninvasive circulating tumour cell DNA testing can be utilized to predict ER. Treatment strategies may involve radical surgery, radiation therapy, chemotherapy, and immunotherapy. Through a comprehensive analysis of risk factors, the optimization of monitoring methods, and the development of personalized treatment strategies, it is anticipated that both the efficacy of treatment and the quality of life for rectal cancer patients with postoperative recurrence can be significantly improved.
Core Tip: This study primarily examines the risk factors, monitoring methods, and treatment strategies for the early recurrence of rectal cancer following surgery. By optimizing monitoring methods and developing individualized treatment plans, the risk of recurrence can be minimized, and treatment outcomes can be improved.
