Wu Z, Cai HQ, Wang CF, Yu XY, Wang JQ. Pain and immune function in patients undergoing gastric cancer surgery following stellate ganglion block with total intravenous anesthesia. World J Gastrointest Surg 2024; 16(9): 2961-2967 [DOI: 10.4240/wjgs.v16.i9.2961]
Corresponding Author of This Article
Jie-Qiong Wang, Doctor, Surgeon, Department of Anesthesiology, The Kunshan Second People’s Hospital, No. 142 Zhongshan Road, Kunshan 215300, Jiangsu Province, China. 624686483@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Observational Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Sep 27, 2024; 16(9): 2961-2967 Published online Sep 27, 2024. doi: 10.4240/wjgs.v16.i9.2961
Pain and immune function in patients undergoing gastric cancer surgery following stellate ganglion block with total intravenous anesthesia
Zhen Wu, Hong-Qin Cai, Chun-Feng Wang, Xiang-Yuan Yu, Jie-Qiong Wang
Zhen Wu, Hong-Qin Cai, Chun-Feng Wang, Xiang-Yuan Yu, Jie-Qiong Wang, Department of Anesthesiology, The Kunshan Second People’s Hospital, Kunshan 215300, Jiangsu Province, China
Co-first authors: Zhen Wu and Hong-Qin Cai.
Author contributions: Wu Z and Cai HQ designed the research study; Wu Z, Wang CF, Yu XY, and Wang JQ performed the research, contributed new reagents and analytical tools; Wu Z and Cai HQ analyzed the data and wrote the manuscript; all authors have read and approved the final manuscript.
Supported byThe Kunshan Social Development Science and Technology Special Project, No. KS2241.
Institutional review board statement: This study was conducted through an ethical review at The Kunshan Second People's Hospital.
Informed consent statement: All study participants or their legal guardians provided written informed consent before study enrollment.
Conflict-of-interest statement: The authors declare no conflicts of interest related to this study or its publication.
Data sharing statement: No additional data are available.
STROBE statement: The authors read the STROBE Statement checklist of items, and the manuscript was prepared and revised accordingly.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jie-Qiong Wang, Doctor, Surgeon, Department of Anesthesiology, The Kunshan Second People’s Hospital, No. 142 Zhongshan Road, Kunshan 215300, Jiangsu Province, China. 624686483@qq.com
Received: June 17, 2024 Revised: July 11, 2024 Accepted: July 19, 2024 Published online: September 27, 2024 Processing time: 92 Days and 13.5 Hours
Abstract
BACKGROUND
Stellate ganglion block is a commonly used sympathetic nerve block technique that restores the balance of the sympathetic and vagal nervous systems of the body and inhibits sympathetic nerve activity.
AIM
To analyze the effect of a stellate ganglion block combined with total diploma intravenous anesthesia on postoperative pain and immune function in patients undergoing laparoscopic radical gastric cancer (GC) surgery to provide a reference basis for the formulation of anesthesia protocols for radical GC surgery.
METHODS
This study included 112 patients who underwent laparoscopic radical surgery for GC between January 2022 and March 2024. There was no restriction on sex. The patient grouping method used was a digital random table method, and the number of cases in each group was 56. The control group was administered total intravenous anesthesia, and the observation group compounded the stellate ganglion block according to the total intravenous anesthesia protocol. Postoperative hemodynamics, pain levels, and immune indices were compared between the groups.
RESULTS
The heart rate and mean arterial pressure in the observation group after intubation were lower than those in the control group (P < 0.05). Pain levels were compared between the two groups at 2 hours, 12 hours, 24 hours, and 48 hours after surgery (P > 0.05). The number of CD3+, CD4+, and CD4+/CD8+ cells at the end of surgery was higher in the observation group than in the control group, and the number of CD8+ cells was lower in the observation group than in the control group (P < 0.05). There were no significant differences between the two groups in terms of propofol dosage, awakening time, extubation time, or postoperative adverse reactions (P > 0.05).
CONCLUSION
The application of a stellate ganglion block combined with total intravenous anesthesia had no significant effect on postoperative pain levels in patients undergoing laparoscopic radical GC surgery. However, it can safely reduce the effect of surgery on the immune function of patients and is worth applying in clinical practice.
Core Tip: In this study, we found that stellate ganglion block combined with general intravenous anesthesia could decrease the need for analgesic drugs and possibly improve immune function in patients undergoing laparoscopic radical surgery for gastric cancer, thus providing novel avenues for optimal surgical anesthesia management.
