Hu Q, Chen XP, Tang ZJ, Zhu XY, Liu C. Therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer. World J Gastrointest Surg 2024; 16(7): 2183-2193 [PMID: 39087096 DOI: 10.4240/wjgs.v16.i7.2183]
Corresponding Author of This Article
Chun Liu, MM, Associate Chief Physician, Department of Anorectal Surgery, The First Traditional Chinese Medicine Hospital of Changde, No. 1988 Ziling Road, Wuling District, Changde 415000, Hunan Province, China. sztcta@126.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2183-2193 Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2183
Therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after routine surgery and chemotherapy for colorectal cancer
Qi Hu, Xiao-Pin Chen, Zhi-Jun Tang, Xue-Yuan Zhu, Chun Liu
Qi Hu, College of Integrated Traditional Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, Hunan Province, China
Xiao-Pin Chen, Department of Anorectal Surgery, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, China
Zhi-Jun Tang, Chun Liu, Department of Anorectal Surgery, The First Traditional Chinese Medicine Hospital of Changde, Changde 415000, Hunan Province, China
Xue-Yuan Zhu, Intensive Care Unit, The First Traditional Chinese Medicine Hospital of Changde, Changde 415000, Hunan Province, China
Author contributions: Hu Q and Liu C conceived and designed the study and critically revised the manuscript; Tang ZJ and Zhu XY acquired and analyzed the data and drafted the manuscript; Chen XP revised the manuscript; and all authors gave final approval.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board of the First Traditional Chinese Medicine Hospital of Changde (Approval No. 2023-082-01).
Informed consent statement: Informed consent from the patients was waived.
Conflict-of-interest statement: The authors declare no conflict of interest for this article.
Data sharing statement: Data used in this study are obtained from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Chun Liu, MM, Associate Chief Physician, Department of Anorectal Surgery, The First Traditional Chinese Medicine Hospital of Changde, No. 1988 Ziling Road, Wuling District, Changde 415000, Hunan Province, China. sztcta@126.com
Received: April 8, 2024 Revised: May 13, 2024 Accepted: May 28, 2024 Published online: July 27, 2024 Processing time: 104 Days and 22 Hours
Abstract
BACKGROUND
According to the theory of traditional Chinese medicine (TCM), the spleen and stomach are the basis of acquired nature and the source of qi and blood biochemistry. After surgery and chemotherapy, patients with colorectal cancer often develop spleen and stomach qi deficiency syndrome, leading to decreased immune function. Buzhong Yiqi decoction, a classic TCM prescription, has the effect of tonifying middle-jiao and invigorating qi, boosting Yang, and suppressing immune-related inflammation. Moreover, it is widely used in the treatment of spleen and stomach qi deficiency syndrome.
AIM
To investigate the effect of Buzhong Yiqi decoction on spleen and stomach qi deficiency in patients with colorectal cancer.
METHODS
One hundred patients with colorectal cancer who underwent preoperative chemotherapy and laparoscopy at The First TCM Hospital of Changde from January 2022 to October 2023 were retrospectively analyzed. The patients were divided equally into control and observation groups. Both groups underwent conventional rehabilitation surgery, and the observation group was supplemented with Buzhong Yiqi decoction. SPSS 26.0 was used for statistical analyses. The χ2 test was used for univariate analysis; independent sample t-tests were used in all cases.
RESULTS
No significant differences were observed preoperatively in the general characteristics of the two groups. Fourteen days post-surgery, the abdominal distension, emaciation, loose stool, loss of appetite, and vomiting scores were significantly lower in the observation group than in the control group (P < 0.05). Immune function and interleukin (IL)-10 levels in the observation group were significantly higher than those of the control group, whereas IL-6, tumor necrosis factor-α, and C-reactive protein levels, tumor biological indexes, and adverse reactions in the observation group were significantly lower than those of the control group (P < 0.05). One month after surgery, the patients’ quality of life in the observation group was significantly higher than that of the patients in the control group (P < 0.05).
CONCLUSION
Buzhong Yiqi decoction can regulate inflammatory responses and metabolic processes by enhancing immune function, thereby promoting overall immune nutrition and restoring the body’s balance.
Core Tip: Through a retrospective analysis, this study investigated the therapeutic effects of Buzhong Yiqi decoction in patients with spleen and stomach qi deficiency after neoadjuvant chemotherapy and laparoscopic radical surgery for colorectal cancer. The results showed that Buzhong Yiqi decoction significantly improved symptoms, enhanced immune function, reduced the levels of inflammatory mediators, and improved the quality of life of the patients.
