Diao YH, Shu XP, Tan C, Wang LJ, Cheng Y. Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery. World J Gastrointest Surg 2024; 16(7): 2096-2105 [PMID: 39087136 DOI: 10.4240/wjgs.v16.i7.2096]
Corresponding Author of This Article
Yong Cheng, PhD, Chief Doctor, Professor, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. chengyongcq@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Jul 27, 2024; 16(7): 2096-2105 Published online Jul 27, 2024. doi: 10.4240/wjgs.v16.i7.2096
Preoperative albumin-bilirubin score predicts short-term outcomes and long-term prognosis in colorectal cancer patients undergoing radical surgery
Yu-Hang Diao, Xin-Peng Shu, Can Tan, Li-Juan Wang, Yong Cheng
Yu-Hang Diao, Xin-Peng Shu, Can Tan, Li-Juan Wang, Yong Cheng, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China
Co-first authors: Yu-Hang Diao and Xin-Peng Shu.
Author contributions: Diao YH and Shu XP contributed to the data analysis; Cheng Y led the quality assessments; Diao YH wrote the original draft; Shu XP and Cheng Y revised the manuscript. The data was gathered by all the authors. All authors have agreed on the manuscript to be submitted, provided final approval of the version to be published, and agree to be responsible for all elements of the work. Diao YH and Shu XP contributed equally to this work.
Institutional review board statement: This study was reviewed and approved by the Ethics Committee of The First Affiliated Hospital of Chongqing Medical University.
Informed consent statement: This is a retrospective study, and the patients came from a teaching hospital of the First Affiliated Hospital of Chongqing Medical University. When we delivered the ethics application, we also delivered application for exemption of informed consent.
Conflict-of-interest statement: The authors declare no conflicts of interest for this article.
Data sharing statement: The datasets generated and/or analyzed during the current study are not publicly available due but are available from the corresponding author upon reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong Cheng, PhD, Chief Doctor, Professor, Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuanjiagang, Yuzhong District, Chongqing 400016, China. chengyongcq@163.com
Received: March 10, 2024 Revised: May 9, 2024 Accepted: June 5, 2024 Published online: July 27, 2024 Processing time: 134 Days and 0.6 Hours
Abstract
BACKGROUND
The albumin-bilirubin (ALBI) score is a serum biochemical indicator of liver function and has been proven to have prognostic value in a variety of cancers. In colorectal cancer (CRC), a high ALBI score tends to be associated with poorer survival.
AIM
To investigate the correlation between the preoperative ALBI score and outcomes in CRC patients who underwent radical surgery.
METHODS
Patients who underwent radical CRC surgery between January 2011 and January 2020 at a single clinical center were included. The ALBI score was calculated by the formula (log10 bilirubin × 0.66) + (albumin × -0.085), and the cutoff value for grouping patients was -2.8. The short-term outcomes, overall survival (OS), and disease-free survival (DFS) were calculated.
RESULTS
A total of 4025 CRC patients who underwent radical surgery were enrolled in this study, and there were 1908 patients in the low ALBI group and 2117 patients in the high ALBI group. Cox regression analysis revealed that age, tumor size, tumor stage, ALBI score, and overall complications were independent risk factors for OS; age, tumor stage, ALBI score, and overall complications were identified as independent risk factors for DFS.
CONCLUSION
A high preoperative ALBI score is correlated with adverse short-term outcomes, and the ALBI score is an independent risk factor for OS and DFS in patients with CRC undergoing radical surgery.
Core Tip: The albumin-bilirubin (ALBI) scoring system is an objective and convenient method for evaluating liver function, and its prognostic value in a variety of cancers has been gradually recognized. In this study, patients who underwent radical surgery for colorectal cancer (CRC) were enrolled and divided into a high-ALBI score group (ALBI score > -2.8) and a low-ALBI score group (ALBI score ≤ -2.8) according to the cutoff calculated with X-tile software, and the results showed that the ALBI score is an independent risk factor for overall survival and disease-free survival in CRC patients undergoing radical resection.
