Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jun 27, 2024; 16(6): 1700-1708
Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1700
Clinical efficacy of laparoscopic cholecystectomy combined with endoscopic papillary balloon dilation in treatment of gallbladder stones with common bile duct stones: A retrospective study
Hong-Dan Liu, Qi Zhang, Wen-Si Xu, Shuang Jin
Hong-Dan Liu, Qi Zhang, Wen-Si Xu, Shuang Jin, Department of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar 161000, Heilongjiang Province, China
Author contributions: Liu HD and Jin S contributed to the conception and design of this study, collection and assembly of the data, and data analysis and interpretation; Liu HD participated in the administrative support; Liu HD, Zhang Q, Xu WS, and Jin S were involved in the provision of study materials or patients of this study; and all authors wrote the manuscript and approved the final manuscript.
Supported by Qiqihar Science and Technology Plan Joint Guidance Project, No. LHYD-2021058.
Institutional review board statement: The study was approved by the Ethics Committee of The Third Affiliated Hospital of Qiqihar Medical University (No. 2023LW-3) and conducted in accordance with the Declaration of Helsinki.
Informed consent statement: All participants provided written informed consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The datasets used or analysed during the current study are available from the corresponding authors on reasonable request.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Shuang Jin, MM, Attending Doctor, Department of Gastroenterology, The Third Affiliated Hospital of Qiqihar Medical University, No. 3 Taishun Street, Qiqihar 161000, Heilongjiang Province, China. jinshuang8877@qmu.edu.cn
Received: March 1, 2024
Revised: May 8, 2024
Accepted: May 27, 2024
Published online: June 27, 2024
Processing time: 121 Days and 0.1 Hours
Abstract
BACKGROUND

The incidence of cholelithiasis has been on the rise in recent years, but the choice of procedure is controversial.

AIM

To investigate the efficacy of laparoscopic cholecystectomy (LC) combined with endoscopic papillary balloon dilation (EPBD) in patients with gallbladder stones (GS) with common bile duct stones (CBDS).

METHODS

The clinical data of 102 patients with GS combined with CBDS were selected for retrospective analysis and divided into either an LC + EPBD group (n = 50) or an LC + endoscopic sphincterotomy (EST) group (n = 52) according to surgical methods. Surgery-related indexes, postoperative recovery, postoperative complications, and expression levels of inflammatory response indexes were compared between the two groups.

RESULTS

Total surgical time, stone free rate, rate of conversion to laparotomy, and successful stone extraction rate did not differ significantly between the LC + EPBD group and LC + EST group. Intraoperative hemorrhage, time to ambulation, and length of hospitalization in the LC + EPBD group were lower than those of the LC + EST group (P < 0.05). The rate of total complications of the two groups was 9.80% and 17.65%, respectively, and the difference was not statistically significant. No serious complications occurred in either group. At 48 h postoperatively, the expression levels of interleukin-6, tumor necrosis factor-α, high-sensitivity C-reactive protein, and procalcitonin were lower in the LC + EPBD group than in the LC + EST group (P < 0.05). At 3 d postoperatively, the expression levels of aspartate transaminase, alanine transaminase, and total bilirubin were lower in the LC + EPBD group than in the LC + EST group (P < 0.05).

CONCLUSION

LC combined with EPBD and LC combined with EST are both effective procedures for the treatment of GS with CBDS, in which LC combined with EPBD is beneficial to shorten the patient’s hospitalization time, reduce the magnitude of elevated inflammatory response indexes, and promote postoperative recovery.

Keywords: Gallbladder stone, Common bile duct stone, Endoscopic papillary balloon dilation, Laparoscopic cholecystectomy, Endoscopic sphincterotomy

Core Tip: The study investigated the efficacy of laparoscopic cholecystectomy (LC) combined with endoscopic papillary balloon dilation (EPBD) and LC combined with endoscopic sphincterotomy (EST) in the treatment of gallbladder stones with common bile duct stones. The results demonstrated a significant reduction in intraoperative bleeding and postoperative recovery time in the LC + EPBD group compared to the LC + EST group. Additionally, there was a notable improvement in inflammatory indexes and liver function. Therefore, LC combined with EPBD may be beneficial to the hospitalization time and inflammatory response of such patients.