Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1660
Revised: April 24, 2024
Accepted: May 9, 2024
Published online: June 27, 2024
Processing time: 144 Days and 3.9 Hours
Advanced gastric cancer is a common malignancy that is often diagnosed at an advanced stage and is still at risk of recurrence after radical surgical treatment. Chemoradiotherapy, as one of the important treatment methods for gastric cancer, is of great significance for improving the survival rate of patients. However, the tumor recurrence and survival prognosis of gastric cancer patients after radio
To analyze the tumor recurrence after radical radiotherapy and chemotherapy for advanced gastric cancer and provide more in-depth guidance for clinicians.
A retrospective analysis was performed on 171 patients with gastric cancer who received postoperative adjuvant radiotherapy and chemotherapy in our hospital from 2021 to 2023. The Kaplan-Meier method was used to calculate the recurrence rate and survival rate; the log-rank method was used to analyze the single-factor prognosis; and the Cox model was used to analyze the prognosis associated with multiple factors.
The median follow-up time of the whole group was 63 months, and the follow-up rate was 93.6%. Stage II and III patients accounted for 31.0% and 66.7%, respec
Postoperative intensity-modulated radiotherapy combined with chemotherapy for gastric cancer treatment is well tolerated and has acceptable adverse effects, which is beneficial for local tumor control and can improve the long-term survival of patients. The LNR was an independent prognostic factor for OS. For patients with a high risk of local recurrence, postoperative adjuvant chemoradiation should be considered.
Core Tip: This study analyzed the tumor recurrence and survival prognosis of patients with advanced gastric cancer after radical radiotherapy and chemotherapy, and explored the related influencing factors. By collecting clinical data of patients for analysis, we will reveal the actual situation of postoperative recurrence rate and survival rate, and further explore the possible influencing factors, so as to provide scientific basis for clinical practice. The innovation of this study lies in the in-depth analysis of the recurrence pattern and prognostic factors of gastric cancer patients after radical radiotherapy and chemotherapy, which provides a new idea for the formulation of individualized treatment plan, and is expected to provide an important reference for the management and prognosis assessment of patients with advanced gastric cancer.