Published online Jun 27, 2024. doi: 10.4240/wjgs.v16.i6.1582
Revised: April 27, 2024
Accepted: May 16, 2024
Published online: June 27, 2024
Processing time: 114 Days and 14.5 Hours
Intraoperative persistent hypotension (IPH) during pancreaticoduodenectomy (PD) is linked to adverse postoperative outcomes, yet its risk factors remain unclear.
To clarify the risk factors associated with IPH during PD, ensuring patient safety in the perioperative period.
A retrospective analysis of patient records from January 2018 to December 2022 at the First Affiliated Hospital of Nanjing Medical University identified factors associated with IPH in PD. These factors included age, gender, body mass index, American Society of Anesthesiologists classification, comorbidities, medication history, operation duration, fluid balance, blood loss, urine output, and blood gas parameters. IPH was defined as sustained mean arterial pressure < 65 mmHg, requiring prolonged deoxyepinephrine infusion for > 30 min despite additional deoxyepinephrine and fluid treatments.
Among 1596 PD patients, 661 (41.42%) experienced IPH. Multivariate logistic regression identified key risk factors: increased age [odds ratio (OR): 1.20 per decade, 95% confidence interval (CI): 1.08-1.33] (P < 0.001), longer surgery duration (OR: 1.15 per additional hour, 95%CI: 1.05-1.26) (P < 0.01), and greater blood loss (OR: 1.18 per 250-mL increment, 95%CI: 1.06-1.32) (P < 0.01). A novel finding was the association of arterial blood Ca2+ < 1.05 mmol/L with IPH (OR: 2.03, 95%CI: 1.65-2.50) (P < 0.001).
IPH during PD is independently associated with older age, prolonged surgery, increased blood loss, and lower plasma Ca2+.
Core Tip: This study examines risk factors for intraoperative persistent hypotension (IPH) in pancreaticoduodenectomy. Key risk factors include patient age, prolonged surgery duration, greater blood loss, and lower calcium levels. Prompt recognition and early intervention can effectively mitigate IPH in these operations.