Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1371
Revised: February 28, 2024
Accepted: April 17, 2024
Published online: May 27, 2024
Processing time: 155 Days and 8 Hours
Appendectomy is an acute abdominal surgery that is often accompanied by severe abdominal inflammation. Oral probiotics are one of the postoperative treat
To investigate whether the postoperative probiotics can modulate the inflammatory response and restore intestinal function in patients following appendec
This was a prospective, randomized trial. A total of 60 emergency patients were randomly divided into a control group (n = 30) and a probiotic group (n = 30). Pa
A total of 60 participants were included. Compared with those in the control group, the C-reactive protein (CRP), interleukin 6 and procalcitonin (PCT) levels were significantly lower in the probiotic group at 2 d after surgery (P = 2.224e-05, P = 0.037, and P = 0.002, respectively, all P < 0.05). This trend persisted at day 5 post-surgery, with CRP and PCT levels remaining significantly lower in the probiotic group (P = 0.001 and P = 0.043, both P < 0.05). Furthermore, probiotics resulted in a shorter time to first flatus and a greater percentage of gram-negative bacilli in the feces (P = 0.035, P = 0.028, both P < 0.05).
Postoperative oral administration of probiotics may modulate the gut microbiota, benefit the recovery of the early inflammatory response, and subsequently enhance recovery after appendectomy.
Core Tip: This research examines the impact of administering oral probiotics postoperatively on inflammation responses and intestinal function in patients undergoing appendectomy procedures. Our findings reveal that orally administered probiotics effectively decrease postoperative inflammatory indicators and enhance intestinal functionality, thereby resulting in reduced hospitalization durations. These insights highlight the potential contribution of probiotics in expediting post-surgical recovery and offer novel approaches for clinical application.