Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1344
Revised: April 6, 2024
Accepted: April 15, 2024
Published online: May 27, 2024
Processing time: 116 Days and 3.5 Hours
Preoperative serum tumor markers not only play a role in the auxiliary diagnosis and postoperative monitoring in colorectal cancer (CRC), but also have been found to have potential prognostic value.
To analyze whether preoperative serum tumor markers, including carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9), affect the prog
This was a retrospective study conducted in a single center. Patients with non
Eventually, 3526 postoperative patients with nonmetastatic CRC were included in the study. There were 2473 patients at the development site and 1056 patients at the validation site. Age (P < 0.01, HR = 1.042, 95%CI = 1.033-1.051), tumor node metastasis (TNM) classification (P < 0.01, HR = 1.938, 95%CI = 1.665-2.255), preoperative CEA (P = 0.001, HR = 1.393, 95%CI = 1.137-1.707) and CA19-9 (P < 0.01, HR = 1.948, 95%CI = 1.614-2.438) levels were considered independent prog
We successfully constructed a nomogram model based on age, TNM stage, preoperative CEA, and CA19-9 levels to evaluate the overall survival of patients with nonmetastatic CRC.
Core Tip: The tumor markers carcinoembryonic antigen and carbohydrate antigen 19-9 are often used in the auxiliary diagnosis and postoperative monitoring of colorectal patients, but their role in prognosis needs to be further explored. Here, we retrospectively analyzed the clinical data and pathological characteristics of 3526 patients with nonmetastatic colorectal cancer (CRC), confirmed the negative correlation between preoperative serum tumor marker levels and prognosis, and established a nomogram model to evaluate the prognosis of CRC patients.