Cao F, Chen YY, Wang HC. GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis. World J Gastrointest Surg 2024; 16(5): 1328-1335 [PMID: 38817299 DOI: 10.4240/wjgs.v16.i5.1328]
Corresponding Author of This Article
Feng Cao, MM, Doctor, Department of Care Section, Beijing Geriatric Hospital, No. 118 Wenquan Road, Wenquan Town, Haidian District, Beijing 100095, China. caofengbj@163.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Retrospective Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. May 27, 2024; 16(5): 1328-1335 Published online May 27, 2024. doi: 10.4240/wjgs.v16.i5.1328
GLI1 and PTTG1 expression in colorectal carcinoma patients undergoing radical surgery and their correlation with lymph node metastasis
Feng Cao, Yang-Yan Chen, Hong-Cheng Wang
Feng Cao, Department of Care Section, Beijing Geriatric Hospital, Beijing 100095, China
Yang-Yan Chen, Research Department, Shanghai Zhangjiang Institute of Medical Innovation, Shanghai 200000, China
Hong-Cheng Wang, Care Department, Beijing Geriatric Hospital, Beijing 100095, China
Co-first authors: Feng Cao and Yang-Yan Chen.
Author contributions: Cao F and Chen YY contributed equally to this work and are co-first authors; Cao F and Chen YY designed the research and wrote the first manuscript; Cao F, Chen YY and Wang HC contributed to conceiving the research and analyzing data; Cao F and Chen YY conducted the analysis and provided guidance for the research; all authors reviewed and approved the final manuscript.
Institutional review board statement: This study was approved by the Ethic Committee of Shanghai Zhangjiang Institute of Medical Innovation.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that were obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: Dr. Cao has nothing to disclose.
Data sharing statement: All data and materials are available from the corresponding author.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Cao, MM, Doctor, Department of Care Section, Beijing Geriatric Hospital, No. 118 Wenquan Road, Wenquan Town, Haidian District, Beijing 100095, China. caofengbj@163.com
Received: February 22, 2024 Revised: April 11, 2024 Accepted: April 12, 2024 Published online: May 27, 2024 Processing time: 91 Days and 8 Hours
Abstract
BACKGROUND
Few studies have investigated the expression of GLI1 and PTTG1 in patients undergoing radical surgery for colorectal carcinoma (CRC) and their association with lymph node metastasis (LNM). Therefore, more relevant studies and analyses need to be conducted.
AIM
To explore GLI1 and PTTG1 expression in patients undergoing radical surgery for CRC and their correlation with LNM.
METHODS
This study selected 103 patients with CRC admitted to our hospital between April 2020 and April 2023. Sample specimens of CRC and adjacent tissues were collected to determine the positive rates and expression levels of GLI1 and PTTG1. The correlation of the two genes with patients’ clinicopathological data (e.g., LNM) was explored, and differences in GLI1 and PTTG1 expression between patients with LNM and those without were analyzed. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive potential of the two genes for LNM in patients with CRC.
RESULTS
Significantly higher positive rates and expression levels of GLI1 and PTTG1 were observed in CRC tissue samples compared with adjacent tissues. GLI1 and PTTG1 were strongly linked to LNM in patients undergoing radical surgery for CRC, with higher GLI1 and PTTG1 levels found in patients with LNM than in those without. The areas under the ROC curve of GLI1 and PTTG1 in assessing LNM in patients with CRC were 0.824 and 0.811, respectively.
CONCLUSION
GLI1 and PTTG1 expression was upregulated in patients undergoing radical surgery for CRC and are significantly related to LNM in these patients. Moreover, high GLI1 and PTTG1 expression can indicate LNM in patients with CRC undergoing radical surgery. The expression of both genes has certain diagnostic and therapeutic significance.
Core Tip: The main goal of radical surgery for colorectal carcinoma (CRC) is to completely remove the primary tumor and regional lymph nodes. Lymph nodes are essential in predicting patient prognosis and for determining the need for adjuvant chemotherapy after surgical resection. In this study, the expression of GLI1 and PTTG1 in patients with CRC undergoing radical surgery and their correlation with lymph node metastasis (LNM) were examined. Aberrant overexpression of GLI1 and PTTG1 was confirmed in patients undergoing radical surgery for CRC. In addition, both GLI1 and PTTG1 were significantly related to LNM and could be used as predictors of LNM, indicating their clinical significance in the evaluation of CRC cases and the development of treatment plans.
