Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Mar 27, 2024; 16(3): 860-870
Published online Mar 27, 2024. doi: 10.4240/wjgs.v16.i3.860
Influence of different magnetic forces on the effect of colonic anastomosis in rats
Bo-Yan Tian, Miao-Miao Zhang, Jia Ma, Yi Lyu, Xiao-Peng Yan
Bo-Yan Tian, Miao-Miao Zhang, Yi Lyu, Xiao-Peng Yan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Miao-Miao Zhang, Yi Lyu, Xiao-Peng Yan, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jia Ma, Department of Surgical Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China
Co-first authors: Bo-Yan Tian and Miao-Miao Zhang.
Co-corresponding authors: Xiao-Peng Yan and Yi Lyu.
Author contributions: Lyu Y and Yan XP designed and coordinated the study; Tian BY, Zhang MM, Ma J, Yan XP performed the research and acquired the data; Tian BY, Zhang MM, Ma J analyzed the data; Zhang MM tested and analyzed the magnetic test; Tian BY, Zhang MM and Yan XP wrote the manuscript; Yan XP and Lyu Y conceived of the study and contributed to the study design, the interpretation of the results, and the critical revision of the manuscript; Yan XP and Zhang MM proposed the “Yan-Zhang’s Magnetic Force Sea-Level Theory”; all authors read and approved the final manuscript.
Supported by the Key Research and Development Program of Shaanxi, No. 2022SF-036; the Institutional Foundation of The First Affiliated Hospital of Xi’an Jiaotong University, No. 2022MS-07; and the Fundamental Research Funds for the Central Universities, No. xzy022023068.
Institutional review board statement: This study was reviewed and approved by the Xi’an Jiaotong University Institution Review Board, No. 2021-1534.
Institutional animal care and use committee statement: The study protocol and all experimental procedures were carried out strictly in accordance with the Guidelines for Care and Use of Experimental Animals issued by the Xi’an Jiaotong University Medical Center. This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University, No. 2021-1534.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that the data supporting the findings of this study are available within the article or from the corresponding authors upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Peng Yan, MD, PhD, Associate Research Scientist, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. yanxiaopeng9966@163.com
Received: October 16, 2023
Peer-review started: October 16, 2023
First decision: January 12, 2024
Revised: January 18, 2024
Accepted: February 6, 2024
Article in press: February 6, 2024
Published online: March 27, 2024
Processing time: 158 Days and 2.5 Hours
Abstract
BACKGROUND

Despite much work having been conducted on magnetic compression anastomosis (MCA) in the digestive tract, there are no reports on the influence of magnetic force on the anastomosis.

AIM

To investigate the effect of different magnetic force magnets on the MCA of the digestive tract.

METHODS

Two groups of magnets of the same sizes but different magnetic forces were designed and produced. A total of 24 Sprague-Dawley rats were randomly assigned into two groups (powerful magnet group and common magnet group), with 12 rats in each group. Two types of magnets were used to complete the colonic side-to-side anastomosis of the rats. The operation time and magnet discharge time were recorded. The anastomotic specimens were obtained 4 wk after the operation and then the burst pressure and diameter of the anastomosis were measured, and the anastomosis was observed via the naked eye and subjected to histological examination.

RESULTS

The magnetic forces of the powerful and common magnet groups at zero distance were 8.26 N and 4.10 N, respectively. The colonic side-to-side anastomosis was completed in all 24 rats, and the operation success rate and postoperative survival rate were 100%. No significant difference was noted in the operation time between the two groups. The magnet discharge time of the powerful magnet group was slightly longer than that of the common magnet group, but the difference was not statistically significant (P = 0.513). Furthermore, there was no statistical difference in the burst pressure (P = 0.266) or diameter of magnetic anastomosis (P = 0.095) between the two groups. The gross specimens of the two groups showed good anastomotic healing, and histological observation indicated good mucosal continuity without differences on healing.

CONCLUSION

In the rat colonic side-to-side MCA model, both the powerful magnet with 8.26 N and the common magnet with 4.10 N showed no significant impact on the anastomosis establishment process or its effect.

Keywords: Magnetosurgery; Magnetic compression anastomosis; Colonic anastomosis; Magnetic force; Rats

Core Tip: Magnetic compression anastomosis, which is a new type of anastomosis, has been extensively studied in digestive tract anastomosis in animals and humans. Previous studies have focused on the feasibility and safety of different magnetic designs for gastrointestinal anastomosis. Moreover, some scholars have proposed the hypothesis that magnetic force may affect the anastomosis effect. In this study, two groups of magnets matched for shape and size but with different magnetic forces were used in colonic side-to-side anastomosis experiments. The findings demonstrated that magnetic force in the range of 4.10-8.26 N did not affect the colonic side-to-side anastomosis.