Short- and long-term outcomes of surgical treatment in patients with intestinal Behcet’s disease

Abstract

BACKGROUND

Behcet’s disease (BD), a chronic vasculitic disorder affecting multiple organs, is characterized by recurrent oral and genital ulcers, arthritis, vasculitis, and intestinal ulcers. Although intestinal involvement of BD is common in East Asia, the efficacy and long-term outcomes of surgical treatment of intestinal BD still remain to be established.

AIM

To evaluate the postoperative clinical course of intestinal BD and determine factors associated with its recurrence.

METHODS

Data from patients who underwent surgical treatment for intestinal BD between January 2010 and August 2021 were retrospectively reviewed. Patients’ demographics, clinical features, postoperative course, complications, and follow-up data were evaluated.

RESULTS

We analyzed 39 surgeries in 31 patients. The mean patient age was 45.1 years, and the mean interval between the diagnosis of intestinal BD and surgical treatment was 4.9 years (range 1.0-8.0 years). The most common indication for surgery was medical intractability (n = 16, 41.0%), followed by fistula or abscess (n = 11, 28.2%). Laparoscopic approaches were used in 19 patients (48.7%), and 5 patients (12.8%) underwent emergency surgeries. The most common surgical procedure was ileocecal resection (n = 18, 46.2%), followed by right colectomy (n = 11, 28.2%). A diverting stoma was created in only one patient (2.6%). During a mean follow-up period of 45 (range 8-72) months, eight cases (20.5%) of recurrence in five patients required reoperation. The interval between operations was 12.1 months (range 6.3-17.8 mo). Four patients (10.3%) experienced recurrence within 1 year postoperatively, and all eight recurrences occurred within 2 years of the initial surgery. The reoperation rates at 1 and 3 years were 10.3% and 20.5%, respectively. A redo ileocolic anastomosis was performed in all recurrent cases. In multivariate Cox regression analysis, emergency surgery [hazard ratio (HR) 9.357, 95% confidence interval (CI): 1.608-54.453, P = 0.013] and elevated C-reactive protein (CRP) levels (HR 1.154, 95%CI: 1.002–1.328, P = 0.047), but not medication use, were predictors of recurrence.

CONCLUSION

Surgical resection is a feasible treatment option for complicated BD. Reoperation is associated with severe inflammatory conditions, reflected by increased CRP levels and the requirement for emergency surgery.

Keywords: Behcet syndrome; Intestinal; General surgery; Recurrence; Risk factors

Core Tip: Behcet's disease (BD), a chronic vasculitic disorder impacting multiple organs, often necessitates surgical intervention due to medical intractability, fistulas, or abscesses. This study examined 31 patients who underwent surgery for intestinal BD. Recurrence occurred in 20.5% of cases, with all instances happening within two years after surgery. Emergency surgery and elevated C-reactive protein (CRP) levels were predictive of recurrence. This suggests that surgical resection is a viable option for complicated BD, but reoperation is more likely in patients with severe inflammation as indicated by elevated CRP levels and the requirement for emergency surgery.