Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. Jan 27, 2024; 16(1): 6-12
Published online Jan 27, 2024. doi: 10.4240/wjgs.v16.i1.6
Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer
Su-Ting Qian, Fei-Fei Xie, Hao-Yu Zhao, Qing-Sheng Liu, Dan-Li Cai
Su-Ting Qian, Fei-Fei Xie, Hao-Yu Zhao, Department of Digestive, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China
Qing-Sheng Liu, Science and Education Section, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou 310007, Zhejiang Province, China
Dan-Li Cai, Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 311122, Zhejiang Province, China
Author contributions: Cai DL designed the overall concept and outline of the manuscript; Qian ST contributed to the design and writing of the manuscript; Xie FF, Zhao HY, and Liu QS contributed to the editing the manuscript, illustrations, and review of literature.
Conflict-of-interest statement: All authors have no conflict-of-interest to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Dan-Li Cai, MM, Assistant Chief Physician, Intensive Care Unit, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 1 Gaojiao Road, Yuhang District, Hangzhou 311122, Zhejiang Province, China. 13858159603@139.com
Received: November 18, 2023
Peer-review started: November 18, 2023
First decision: December 6, 2023
Revised: December 11, 2023
Accepted: December 26, 2023
Article in press: December 26, 2023
Published online: January 27, 2024
Abstract

Gastric cancer (GC) is a prevalent malignant tumor within the digestive system, with over 40% of new cases and deaths related to GC globally occurring in China. Despite advancements in treatment modalities, such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents, the prognosis for GC remains poor. New targeted therapies and immunotherapies are currently under investigation, but no significant breakthroughs have been achieved. Studies have indicated that GC is a heterogeneous disease, encompassing multiple subtypes with distinct biological characteristics and roles. Consequently, personalized treatment based on clinical features, pathologic typing, and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer (PLGC). Current research has categorized GC into four subtypes: Epstein-Barr virus-positive, microsatellite instability, genome stability, and chromosome instability (CIN). Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas. Among these, ultrasensitive chromosomal aneuploidy detection (UCAD) can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology, in conjunction with bioinformatics analysis, to achieve qualitative and quantitative detection of chromosomal stability. This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

Keywords: Gastric cancer, Precancerous lesions of gastric cancer, Molecular typing, Ultrasensitive chromosomal aneuploidy detection, Adjuvant therapy, Application prospects

Core Tip: The purpose of this editorial is to provide an overview of the current diagnostic and therapeutic guidelines for gastric precancerous lesions, and to explore the potential clinical application of ultrasensitive chromosomal aneuploidy detection in the field of gastric cancer prevention and control. By doing so, this article aims to advance future research in this area.