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World J Gastrointest Surg. Aug 27, 2023; 15(8): 1564-1573
Published online Aug 27, 2023. doi: 10.4240/wjgs.v15.i8.1564
Prevention and treatment of hepatic encephalopathy during the perioperative period of transjugular intrahepatic portosystemic shunt
Lan-Jing Wang, Xin Yao, Qi Qi, Jian-Ping Qin
Lan-Jing Wang, Xin Yao, Qi Qi, Jian-Ping Qin, Department of Gastroenterology, The General Hospital of Western Theater Command, Chengdu 610083, Sichuan Province, China
Author contributions: Qin JP and Yao X contributed to the conception and design of the article and revised the manuscript critically; Wang LJ and Qi Q contributed to literature search and wrote the manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: There is no conflict of interest associated with any of the senior author or other coauthors contributed their efforts in this manuscript.
Data sharing statement: Not available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jian-Ping Qin, MD, Chief Physician, Department of Gastroenterology, The General Hospital of Western Theater Command, No. 270 Rongdu Road, Chengdu 610083, Sichuan Province, China. jpqqing@163.com
Received: March 5, 2023
Peer-review started: March 5, 2023
First decision: April 21, 2023
Revised: May 9, 2023
Accepted: May 22, 2023
Article in press: May 22, 2023
Published online: August 27, 2023
Processing time: 172 Days and 22 Hours
Abstract

Transjugular intrahepatic portosystemic shunt (TIPS) is an established procedure for treating the complications of portal hypertension in liver cirrhosis. While the pathogenesis of postoperative TIPS-related hepatic encephalopathy (HE) has yet to be fully understood, intraoperative portosystemic shunts may provide a pathological basis for the occurrence of postoperative HE in patients with liver cirrhosis. Studies at home and abroad have expressed mixed opinions about TIPS-related HE. This study presents a literature review on the risk factors for and prevention and treatment of perioperative TIPS-related HE in patients with liver cirrhosis, aiming to optimize the procedure and reduce the incidence of postoperative HE.

Keywords: Portosystemic shunt; Transjugular intrahepatic; Hepatic encephalopathy; Liver cirrhosis; Hypertension; Portal; Therapeutics

Core tip: Transjugular intrahepatic portosystemic shunt (TIPS) is a minimally invasive interventional procedure used to treat the complications of portal hypertension in patients with liver cirrhosis of different origins. As the exact pathogenesis of postoperative TIPS-related hepatic encephalopathy (HE) remains unclear, domestic and foreign studies have expressed mixed opinions about TIPS-related HE. This study provides a literature review on the risk factors for and the prevention and treatment of perioperative TIPS-related HE.