Copyright
©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
Primary animal experiment to test the feasibility of a novel Y-Z magnetic hepatic portal blocking band
Miao-Miao Zhang, Chen-Guang Li, Shu-Qin Xu, Jian-Qi Mao, Yu-Xiang Ren, Yu-Han Zhang, Jia Ma, Ai-Hua Shi, Yi Lyu, Xiao-Peng Yan
Miao-Miao Zhang, Shu-Qin Xu, Yi Lyu, Xiao-Peng Yan, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Miao-Miao Zhang, Shu-Qin Xu, Ai-Hua Shi, Yi Lyu, Xiao-Peng Yan, National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Chen-Guang Li, Department of Critical Care Medicine, China-Japan Union Hospital of Jilin University, Changchun 130000, Jilin Province, China
Jian-Qi Mao, Yu-Xiang Ren, Zonglian College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Yu-Han Zhang, Qide College, Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China
Jia Ma, Department of Surgical Oncology, Shaanxi Provincial People's Hospital, Xi'an 710068, Shaanxi Province, China
Author contributions: Zhang MM and Yan XP participated in the design of the Y-Z MHPBB and the study, wrote the draft of the manuscript, and revised it; Li CG, Xu SQ, Mao JQ, Ren YX, Zhang YH, Ma J and Shi AH participated in the design of the study and performed the statistical analysis; Zhang MM, Li CG, Yan XP and Lyu Y contributed to the interpretation of the results and helped to revise the draft; Zhang MM, Li CG, Xu SQ, Mao JQ, Ren YX, Zhang YH, Ma J and Shi AH participated in the magnetic force tests and in vitro simulation experiments; Zhang MM, Li CG, Xu SQ, Mao JQ, Ren YX, Zhang YH, Ma J and Yan XP participated in animal surgery; Yan XP and Lyu Y conceived of the study and contributed to the study design, the interpretation of the results, and the critical revision of the manuscript; All authors read and approved the final manuscript.
Supported by Institutional Foundation of The First Affiliated Hospital of Xi’an Jiaotong University (to Yan XP), No. 2022MS-07.
Institutional review board statement: This study was reviewed and approved by Xi’an Jiaotong University Institution Review Board, No. 2022-1460.
Institutional animal care and use committee statement: The study protocol and all experimental procedures were carried out strictly in accordance with the Guidelines for Care and Use of Experimental Animals issued by the Xi’an Jiaotong University Medical Center. This experimental study was approved by the Experimental Ethics Committee of Xi’an Jiaotong University (No. 2022-1460).
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The authors declare that the data supporting the findings of this study are available within the article or from the corresponding authors upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See:
https://creativecommons.org/Licenses/by-nc/4.0/ Corresponding author: Xiao-Peng Yan, MD, PhD, Associate Research Scientist, Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, No. 277 West Yanta Road, Xi'an 710061, Shaanxi Province, China. yanxiaopeng9966@163.com
Received: January 20, 2023
Peer-review started: January 20, 2023
First decision: March 8, 2023
Revised: March 8, 2023
Accepted: May 5, 2023
Article in press: May 5, 2023
Published online: July 27, 2023
BACKGROUND
Hepatic portal blood flow occlusion is a common technique for reducing hepatic hemorrhage during hepatectomy. We designed a novel Y-Z magnetic hepatic portal blocking band (Y-Z MHPBB) based on the principle of magnetic compression technique.
AIM
To introduce the Y-Z MHPBB device and verify the feasibility of this device for hepatic portal blood flow occlusion in dogs.
METHODS
Ten beagles were randomly divided into the experimental group and control group. The operation time, intraoperative blood loss, the number of portal blood flow occlusions, the total time spent on adjusting the blocking band, and the average time spent on adjusting the blocking band were recorded. The surgeons evaluated the feasibility and flexibility of the two portal occlusion devices.
RESULTS
Laparoscopic hepatectomy was successfully performed in both the experimental group and control group. There was no statistical difference between the two groups in the operation time, intraoperative blood loss, and the number of hepatic portal blood flow occlusions. With respect to the total time spent on adjusting the blocking band and the average time spent on adjusting the blocking band, the experimental group showed significantly better outcomes than the control group, with a statistical difference (P < 0.05). The operators found that the Y-Z MHPBB was superior to the modified T-tube in terms of operational flexibility.
CONCLUSION
The Y-Z MHPBB seems to be an ingenious design, accurate blood flow occlusion effect, and good flexibility; and it can be used for hepatic portal blood flow occlusion during laparoscopic hepatectomy.
Core Tip: Based on the basic principle of magnetic compression technique, we designed a novel Y-Z magnetic hepatic portal blocking band (Y-Z MHPBB) and compared it with a modified T tube through animal experiments. Mechanical tests and in vitro simulation experiments showed that Y-Z MHPBB has good fluid shielding performance. The animal experiment results showed that the device has good flexibility and convenience under laparoscopy. Y-Z MHPBB seems to have broad application prospects in the clinical field.
