Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.698
Peer-review started: November 17, 2022
First decision: January 23, 2023
Revised: February 5, 2023
Accepted: March 3, 2023
Article in press: March 3, 2023
Published online: April 27, 2023
Processing time: 156 Days and 14.9 Hours
Palliative endoscopic biliary drainage is the primary treatment option for the management of patients with jaundice which results from distal malignant biliary obstruction (DMBO). In this group of patients, decompression of the bile duct (BD) allows for pain reduction, symptom relief, chemotherapy administration, improved quality of life, and increased survival rate. To reduce the unfavorable effects of BD decompression, minimally invasive surgical techniques require continuous improvement.
To develop a technique for internal-external biliary-jejunal drainage (IEBJD) and assess its effectiveness in comparison to other minimally invasive procedures in the palliative treatment of patients with DMBO.
A retrospective analysis of prospectively collected data was performed, which included 134 patients with DMBO who underwent palliative BD decompression. Biliary-jejunal drainage was developed to divert bile from the BD directly into the initial loops of the small intestine to prevent duodeno-biliary reflux. IEBJD was carried out using percutaneous transhepatic access. Percutaneous transhepatic biliary drainage (PTBD), endoscopic retrograde biliary stenting (ERBS), and internal-external transpapillary biliary drainage (IETBD) were used for the treatment of study patients. Endpoints of the study were the clinical success of the procedure, the frequency and nature of complications, and the cumulative survival rate.
There were no significant differences in the frequency of minor complications between the study groups. Significant complications occurred in 5 (17.2%) patients in the IEBJD group, in 16 (64.0%) in the ERBS group, in 9 (47.4%) in the IETBD group, and in 12 (17.4%) in the PTBD group. Cholangitis was the most common severe complication. In the IEBJD group, the course of cholangitis was characterized by a delayed onset and shorter duration as compared to other study groups. The cumulative survival rate of patients who underwent IEBJD was 2.6 times higher in comparison to those of the PTBD and IETBD groups and 20% higher in comparison to that of the ERBS group.
IEBJD has advantages over other minimally invasive BD decompression techniques and can be recommended for the palliative treatment of patients with DMBO.
Core Tip: This study compared the new technique of internal-external biliary-jejunal drainage (IEBJD) for bile duct (BD) decompression in patients with obstructive jaundice with commonly used procedures through a retrospective analysis of prospectively collected data. IEBJD was used to divert bile from the BD directly into the initial loops of the small intestine to prevent duodeno-biliary reflux. The application of IEBJD was associated with a decreased incidence of significant complications, a delayed onset of cholangitis and its shorter duration, as well as an increased cumulative survival rate in patients with distal malignant biliary obstruction as compared to commonly used endoscopic ultrasound-guided retrograde and antegrade techniques and internal-external transpapillary biliary drainage.