Kupietzky A, Dover R, Mazeh H. Surgical aspects of small intestinal neuroendocrine tumors. World J Gastrointest Surg 2023; 15(4): 566-577 [PMID: 37206065 DOI: 10.4240/wjgs.v15.i4.566]
Corresponding Author of This Article
Haggi Mazeh, FACS, MD, Associate Professor, Department of Surgery, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, 24035 POD, Jerusalem 91240, Israel. hmazeh@hadassah.org.il
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Apr 27, 2023; 15(4): 566-577 Published online Apr 27, 2023. doi: 10.4240/wjgs.v15.i4.566
Surgical aspects of small intestinal neuroendocrine tumors
Amram Kupietzky, Roi Dover, Haggi Mazeh
Amram Kupietzky, Roi Dover, Haggi Mazeh, Department of Surgery, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91240, Israel
Author contributions: Kupietzky A, Dover R, and Mazeh H had substantial contributions to conception, writing and critically reviewing the research and manuscript; all authors have read and approve the final manuscript.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. There was no external funding for this manuscript.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Haggi Mazeh, FACS, MD, Associate Professor, Department of Surgery, Hadassah Medical Organization and Faculty of Medicine, Hebrew University of Jerusalem, 24035 POD, Jerusalem 91240, Israel. hmazeh@hadassah.org.il
Received: December 9, 2022 Peer-review started: December 9, 2022 First decision: February 8, 2023 Revised: February 25, 2023 Accepted: March 27, 2023 Article in press: March 27, 2023 Published online: April 27, 2023
Abstract
Small intestinal neuroendocrine tumors (NETs) are a heterogeneous group of epithelial tumors with a predominant neuroendocrine differentiation. Although NETs are usually considered rare neoplasms, small intestinal NETs are the most common primary malignancy of the small bowel, with an increasing prevalence worldwide during the course of the past few decades. The indolent nature of these tumors often leads to a delayed diagnosis, resulting in over one-third of patients presenting with synchronous metastases. Primary tumor resection remains the only curative option for this type of tumor. In this review article, the various surgical aspects for the excision of small intestinal NETs are discussed.
Core Tip: Small intestinal neuroendocrine tumors (SINETs) are the most common primary malignancy of the small bowel. While many patients present with mesenteric and liver metastases the primary tumor resection poses a surgical challenge. In this review article, the various surgical aspects for the excision of small intestinal NETs are discussed.
