Zhu ML, Wang LY, Bai XQ, Wu C, Liu XY. Primary malignant melanoma of the esophagus combined with squamous cell carcinoma: A case report. World J Gastrointest Surg 2023; 15(2): 287-293 [PMID: 36896304 DOI: 10.4240/wjgs.v15.i2.287]
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Feb 27, 2023; 15(2): 287-293 Published online Feb 27, 2023. doi: 10.4240/wjgs.v15.i2.287
Primary malignant melanoma of the esophagus combined with squamous cell carcinoma: A case report
Mei-Lin Zhu, Ling-Yun Wang, Xue-Qin Bai, Chen Wu, Xiang-Yu Liu
Mei-Lin Zhu, Department of Geriatrics, Jining No. 1 People's Hospital, Jining 272000, Sahndong Province, China
Ling-Yun Wang, Chen Wu, Xiang-Yu Liu, Department of Gastroenterology, Jining No. 1 People's Hospital, Jining 272000, Shandong Province, China
Xue-Qin Bai, Department of Pathology, Jining No. 1 People's Hospital, Jining 272000, Sahndong Province, China
Chen Wu, College of Clinical Medicine, Jining Medical University, Jining 272013, Shandong Province, China
Author contributions: Zhu ML and Wang LY contributed equally to this work; Zhu ML, Liu XY, Wang LY designed the research report; Bai XQ provided pathological diagnosis and pictures, Zhu ML and Wu C analyzed the data and wrote the manuscript; Wang LY and Liu XY guided and reviewed this article; All authors have read and approved the final manuscript.
Informed consent statement: Informed written consent was obtained from the patients for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors declare that they have no conflict of interest to report.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Received: November 14, 2022 Peer-review started: November 14, 2022 First decision: November 30, 2022 Revised: December 13, 2022 Accepted: January 10, 2023 Article in press: January 10, 2023 Published online: February 27, 2023
Abstract
BACKGROUND
Primary malignant melanoma of the esophagus is a rare malignant tumor of the esophagus, and its combination with squamous cell carcinoma is also rare. Here, we report the diagnosis and treatment of a case of primary esophageal malignant melanoma combined with squamous cell carcinoma.
CASE SUMMARY
A middle-aged man underwent gastroscopy for dysphagia. Gastroscopy revealed multiple bulging esophageal lesions, and after pathologic and immunohistochemical analyses, the patient was finally diagnosed with "malignant melanoma with squamous cell carcinoma". This patient received comprehensive treatment. After one year of follow-up, the patient was in good condition, and the esophageal lesions seen on gastroscopy were controlled, but unfortunately, liver metastasis occurred.
CONCLUSION
When multiple esophageal lesions are present, the possibility of multiple pathological sources should be considered. This patient was diagnosed with primary esophageal malignant melanoma combined with squamous cell carcinoma.
Core Tip: Here, we report a 53-year-old man with primary malignant melanoma of the esophagus combined with squamous cell carcinoma diagnosed by endoscopy, biopsy, imaging evaluation, and physical examination; this diagnosis was confirmed by immunohistochemistry. The patient was treated with immunotherapy, radiotherapy, and chemotherapy. As of now, the patient has recovered well.
