Post-cholecystectomy iatrogenic bile duct injuries: Emerging role for endoscopic management

Abstract

Post-cholecystectomy iatrogenic bile duct injuries (IBDIs), are not uncommon and although the frequency of IBDIs vary across the literature, the rates following the procedure of laparoscopic cholecystectomy are much higher than open cholecystectomy. These injuries caries a great burden on the patients, physicians and the health care systems and sometime are life-threatening. IBDIs are associated with different manifestations that are not limited to abdominal pain, bile leaks from the surgical drains, peritonitis with fever and sometimes jaundice. Such injuries if not witnessed during the surgery, can be diagnosed by combining clinical manifestations, biochemical tests and imaging techniques. Among such techniques abdominal US is usually the first choice while Magnetic Resonance Cholangio-Pancreatography seems the most appropriate. Surgical approach was the ideal approach for such cases, however the introduction of Endoscopic Retrograde Cholangio-Pancreatography (ERCP) was a paradigm shift in the management of such injuries due to accepted success rates, lower cost and lower rates of associated morbidity and mortality. However, the literature lacks consensus for the optimal timing of ERCP intervention in the management of IBDIs. ERCP management of IBDIs can be tailored according to the nature of the underlying injury. For the subgroup of patients with complete bile duct ligation and lost ductal continuity, transfer to surgery is indicated without delay. Those patients will not benefit from endoscopy and hence should not do unnecessary ERCP. For low–flow leaks e.g. gallbladder bed leaks, conservative management for 1-2 wk prior to ERCP is advised, in contrary to high-flow leaks e.g. cystic duct leaks and stricture lesions in whom early ERCP is encouraged. Sphincterotomy plus stenting is the ideal management line for cases of IBDIs. Interventional radiologic techniques are promising options especially for cases of failed endoscopic repair and also for cases with altered anatomy. Future studies will solve many unsolved issues in the management of IBDIs.

Keywords: Iatrogenic bile duct injuries, Cholecystectomy, Surgical repair, Endoscopic Retrograde Cholangio-Pancreatography, Interventional radiology

Core Tip: Post-cholecystectomy iatrogenic bile duct injuries are not uncommon and hence deserve paying attention from surgeons, gastroenterologists and interventional radiologists. Multidisciplinary team is advised aiming to early and appropriately diagnose such injuries, tailor treatment for cases on an individual base. Surgical treatment is the immediate solution for bile duct injuries diagnosed intraoperative in the context of available experienced hepato-biliary surgeon. Endoscopic treatment looks promising and effective treatment options for injuries diagnosed after the surgery, while interventional endoscopic procedures looks valuable for patients with failed endoscopy and patients who had altered anatomy.