Huang RL, Huang WK, Xiao XY, Ma LF, Gu HZR, Yang GP. Diagnosis and treatment of post-cholecystectomy diarrhoea. World J Gastrointest Surg 2023; 15(11): 2398-2405 [PMID: 38111762 DOI: 10.4240/wjgs.v15.i11.2398]
Corresponding Author of This Article
Guo-Ping Yang, PhD, Doctor, Department of Clinical Pharmacy, The Third Hospital of The Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, China. ygp9880@126.com
Research Domain of This Article
Surgery
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Rang-Lang Huang, Department of Hepatobiliary and Pancreatic Surgery, The Third Xiangya Hospital of The Central South University, Changsha 410013, Hunan Province, China
Wen-Kai Huang, Department of General Medicine, The Third Xiangya Hospital of The Central South University, Changsha 410013, Hunan Province, China
Xiang-Yi Xiao, Lin-Feng Ma, He-Zi-Rui Gu, The Xiangya School of Medicine, The Central South University, Changsha 410013, Hunan Province, China
Guo-Ping Yang, Department of Clinical Pharmacy, The Third Hospital of The Central South University, Changsha 410013, Hunan Province, China
Author contributions: Huang RL performed the data analyses and wrote the manuscript; Huang WK, Xiao XY, Ma LF, and Gu HZR collected the data; Yang GP designed the study and provided funding; all authors approved the final article.
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Guo-Ping Yang, PhD, Doctor, Department of Clinical Pharmacy, The Third Hospital of The Central South University, No. 138 Tongzipo Road, Changsha 410013, Hunan Province, China. ygp9880@126.com
Received: May 23, 2023 Peer-review started: May 23, 2023 First decision: July 8, 2023 Revised: July 22, 2023 Accepted: September 22, 2023 Article in press: September 22, 2023 Published online: November 27, 2023
Abstract
The incidence of cholecystitis is relatively high in developed countries and may usually be attributed to gallstones, the treatment for which involves complete surgical removal of the gallbladder (cholecystectomy). Bile acids produced following cholecystectomy continue to flow into the duodenum but are poorly absorbed by the colon. Excessive bile acids in the colon stimulate mucosal secretion of water and electrolytes leading, in severe cases, to diarrhoea. Bile acid diarrhoea (BAD) is difficult to diagnose, requiring a comprehensive medical history and physical examination in combination with laboratory evaluation. The current work reviews the diagnosis and treatment of BAD following cholecystectomy.
Core Tip: The incidence of cholecystitis is relatively high in developed countries, the treatment for which involves complete surgical removal of the gallbladder. Bile acids produced following cholecystectomy are poorly absorbed by the colon. Excessive bile acids in the colon stimulate mucosal secretion of water and electrolytes leading, in severe cases, to diarrhoea. The current work reviews the diagnosis and treatment of bile acid diarrhoea following cholecystectomy.
