Kassi ABF, Yenon KS, Kassi FMH, Adjeme AJ, Diarra KM, Bombet-Kouame C, Kouassi M. Giant dedifferentiated liposarcoma of the gastrocolic ligament: A case report. World J Gastrointest Surg 2023; 15(10): 2376-2381 [PMID: 37969706 DOI: 10.4240/wjgs.v15.i10.2376]
Corresponding Author of This Article
Assamoi Brou Fulgence Kassi, MD, PhD, Assistant Professor, Surgeon, Surgery and Surgical Specialities, Medical Sciences Training and Research Unit, Abidjan Felix Houphouet-Boigny University, Boulevard de l'université, Abidjan 01 BP V 34, Cote d'Ivoire. kassbrouf@gmail.com
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastrointest Surg. Oct 27, 2023; 15(10): 2376-2381 Published online Oct 27, 2023. doi: 10.4240/wjgs.v15.i10.2376
Giant dedifferentiated liposarcoma of the gastrocolic ligament: A case report
Assamoi Brou Fulgence Kassi, Kacou Sebastien Yenon, Fian Marc Herve Kassi, Adja Jacob Adjeme, Khader Morel Diarra, Cynthia Bombet-Kouame, Marcellin Kouassi
Assamoi Brou Fulgence Kassi, Kacou Sebastien Yenon, Surgery and Surgical Specialities, Medical Sciences Training and Research Unit, Abidjan Felix Houphouet-Boigny University, Abidjan 01 BP V 34, Cote d'Ivoire
Assamoi Brou Fulgence Kassi, Kacou Sebastien Yenon, Fian Marc Herve Kassi, Adja Jacob Adjeme, Khader Morel Diarra, Cynthia Bombet-Kouame, Marcellin Kouassi, Surgery and Surgical Specialities, Digestive Surgery Unit, University Hospital of Cocody, Abidjan 01 BP V13, Cote d'Ivoire
Author contributions: Kassi ABF proposed the idea, analyzed the literature, wrote and revised the manuscript according reviewers suggestions; Yenon KS supervised and revised the manuscript; Kassi FMH collected the data; Adjemé AJ and Diarra KM assisted with data collection; Kassi ABF, Yenon KS, Bombet-Kouamé C and Kouassi M were the patient’s surgeons and participated in the entire operation; All the authors have read and approved the revised manuscript.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Assamoi Brou Fulgence Kassi, MD, PhD, Assistant Professor, Surgeon, Surgery and Surgical Specialities, Medical Sciences Training and Research Unit, Abidjan Felix Houphouet-Boigny University, Boulevard de l'université, Abidjan 01 BP V 34, Cote d'Ivoire. kassbrouf@gmail.com
Received: July 1, 2023 Peer-review started: July 1, 2023 First decision: August 4, 2023 Revised: August 17, 2023 Accepted: August 23, 2023 Article in press: August 23, 2023 Published online: October 27, 2023 Processing time: 117 Days and 12.5 Hours
Abstract
BACKGROUND
Dedifferentiated liposarcoma (DDLS) has a worse prognosis and occurs most commonly in the retroperitoneal region and rarely in the intraperitoneal region. Histological diagnosis was revolutionized by the combined contributions of histo-immuno-chemistry and molecular biology. Aside from surgery, there is no consensus on the optimal treatment for this chemoresistant cancer.
CASE SUMMARY
A thirty-year-old black female presented with a large painful abdominal mass occupying nearly the entire abdomen and progressive weight loss was admitted for surgery. Abdominal computed tomography showed a large heterogeneous mass of the mesentery that was sized 18 cm × 16 cm in size and had heterogeneous contrast enhancement. During laparotomy, en bloc excision of the large and multilobulated gastrocolic ligament mass was performed. The initial postoperative histopathological diagnosis was undifferentiated sarcoma. Finally, the results of immunohistochemistry and molecular biology allowed us to confirm the diagnosis of DDLS. The tumour followed an aggressive evolution with diffuse metastasis, causing the death of the patient less than 5 mo after the operation.
CONCLUSION
Dedifferentiated liposarcomas are rare tumours that typically originate in the retroperitoneum but may arise in unexpected locations.
Core Tip: Dedifferentiated liposarcoma has a worse prognosis and occurs most commonly in a retroperitoneal location but rarely in an intraperitoneal location. Complete surgical excision with a negative microscopic margin (R0) remains the ideal treatment when the tumour is still localized. Here, we report the case of a young woman with disseminated giant dedifferentiated liposarcoma of the gastrocolic ligament. This case demonstrates the poor prognosis of dedifferentiated liposarcomas. To the best of our knowledge, a giant dedifferentiated liposarcoma of the gastrocolic ligament has not yet been reported.
