Published online Jul 27, 2021. doi: 10.4240/wjgs.v13.i7.717
Peer-review started: March 29, 2021
First decision: May 28, 2021
Revised: June 4, 2021
Accepted: June 22, 2021
Article in press: June 22, 2021
Published online: July 27, 2021
Processing time: 116 Days and 0.3 Hours
Early oral feeding (EOF) is an important measure for early recovery of patients with gastrointestinal tumors after surgery, which has emerged as a safe and effective postoperative strategy for improving clinical outcomes.
To determine the safety and efficacy of early oral feeding in postoperative patients with upper gastrointestinal tumor.
This meta-analysis was analyzed using Review Manager version 5.3 and Stata version 14. All clinical studies that analyzed efficacy and safety of EOF for postoperative patients with upper gastrointestinal tumor were included.
Fifteen studies comprising 2100 adult patients met all the inclusion criteria. A significantly lower risk of pneumonia was presented in the EOF compared with TOF group [relative risk (RR) = 0.63, 95% confidence interval (CI): 0.44–0.89, P = 0.01]. Length of hospital stay was significantly shorter in the EOF group than in the TOF group [weighted mean difference (WMD) = -1.91, 95%CI: -2.42 to -1.40; P < 0.01]. Cost of hospitalization was significantly lower (WMD = -4.16, 95%CI: -5.72 to -2.61; P < 0.01), and CD4 cell count and CD4/CD8 cell ratio on postoperative day 7 were significantly higher in the EOF group than in the TOF group: CD4 count (WMD = 7.17, 95%CI: 6.48–7.85; P < 0.01), CD4/CD8 ratio (WMD = 0.29, 95%CI: 0.23–0.35; P < 0.01). There was no significant difference in risk of anastomotic leak and total postoperative complications.
EOF as compared with TOF was associated with lower risk of pneumonia, shorter hospital length of stay, lower cost of hospitalization, and significantly improved postoperative immune function of patients.
Core Tip: Postoperative early oral feeding (EOF) is safe and effective for improving clinical outcomes in patients with lower gastrointestinal tumor. To our knowledge, this study is the largest meta-analysis of randomized controlled trials to date, including 2100 participants, of whom 1042 received EOF protocols and 1058 received traditional oral feeding, to assess the safety and efficacy in postoperative patients with upper gastrointestinal tumor. Our review clarified that EOF results in accelerated convalescence, reduction of the risk of pneumonia, length of hospital and medical costs, and better immune status.