Shadhu K, Ramlagun-Mungur D, Ping XC. Ewing sarcoma of the jejunum: A case report and literature review . World J Gastrointest Surg 2021; 13(5): 507-515 [PMID: 34122739 DOI: 10.4240/wjgs.v13.i5.507]
Corresponding Author of This Article
Xiao-Chun Ping, MBBS, MD, PhD, Doctor, Surgeon, Surgical Oncologist, Teacher, Department of General Surgery, Gastrointestinal Surgery, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. pingxiaochun@jsph.org.cn
Research Domain of This Article
Surgery
Article-Type of This Article
Case Report
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Kamleshsingh Shadhu, Dadhija Ramlagun-Mungur, Xiao-Chun Ping, Department of General Surgery, Gastrointestinal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Kamleshsingh Shadhu, Dadhija Ramlagun-Mungur, Pre-registration House Officer, Medical Council of Mauritius, Floreal 0000, Plaine Whilhems, Mauritius
Author contributions: Shadhu K, Ramlagun-Mungur D, and Ping XC made substantial contributions to the conception, acquisition of data, analysis, and interpretation of data; All authors have been involved in drafting the manuscript and revising it critically for important intellectual content; All authors read and approved the final manuscript and take public responsibility for appropriate portions of the content and agreed to be accountable for all aspects of work.
Informed consent statement: Written informed consent was obtained from the participants for publication of this article and any accompanying tables/images. A copy of the written consent is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Xiao-Chun Ping, MBBS, MD, PhD, Doctor, Surgeon, Surgical Oncologist, Teacher, Department of General Surgery, Gastrointestinal Surgery, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. pingxiaochun@jsph.org.cn
Received: August 4, 2020 Peer-review started: August 4, 2020 First decision: September 17, 2020 Revised: September 30, 2020 Accepted: April 29, 2021 Article in press: April 29, 2021 Published online: May 27, 2021 Processing time: 289 Days and 10.5 Hours
Abstract
BACKGROUND
Ewing sarcomas (ESs) are highly aggressive malignancy and are predominant in the long bones of extremities of children and young adults with a slight male predilection and rarely presents at extra skeletal locations.
CASE SUMMARY
A 55-year-old woman came to our hospital after finding elevated tumor biomarkers during her physical examination. Her enhanced computed tomography scan showed a jejunal mass. The patient underwent laparoscopic enterectomy. The mass was later diagnosed as ES, evidenced by fluorescence in situ hybridization whereby the GLP ES breakpoint region 1 probe was used, showing that more than 10% of the cells showed a red-green-yellow signal proving the breakpoint rearrangement of the ES breakpoint region 1 gene in chromosome 22.
CONCLUSION
We describe a case of localized ES at the jejunum in China based on the literature.
Core Tip: Ewing sarcomas (ESs) are a highly aggressive malignancy and are predominant in the long bones of extremities of children and young adults. We hereby present a case of extraosseous ES of the jejunum in a female patient. This case highlights the jejunum as a potential site of ES origin and shows that a surgical approach with adjuvant chemotherapy is beneficial.
