Case Report
Copyright ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Surg. May 27, 2021; 13(5): 507-515
Published online May 27, 2021. doi: 10.4240/wjgs.v13.i5.507
Ewing sarcoma of the jejunum: A case report and literature review
Kamleshsingh Shadhu, Dadhija Ramlagun-Mungur, Xiao-Chun Ping
Kamleshsingh Shadhu, Dadhija Ramlagun-Mungur, Xiao-Chun Ping, Department of General Surgery, Gastrointestinal Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Kamleshsingh Shadhu, Dadhija Ramlagun-Mungur, Pre-registration House Officer, Medical Council of Mauritius, Floreal 0000, Plaine Whilhems, Mauritius
Author contributions: Shadhu K, Ramlagun-Mungur D, and Ping XC made substantial contributions to the conception, acquisition of data, analysis, and interpretation of data; All authors have been involved in drafting the manuscript and revising it critically for important intellectual content; All authors read and approved the final manuscript and take public responsibility for appropriate portions of the content and agreed to be accountable for all aspects of work.
Informed consent statement: Written informed consent was obtained from the participants for publication of this article and any accompanying tables/images. A copy of the written consent is available for review by the Editor of this journal.
Conflict-of-interest statement: The authors declare that they have no competing interests.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
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Corresponding author: Xiao-Chun Ping, MBBS, MD, PhD, Doctor, Surgeon, Surgical Oncologist, Teacher, Department of General Surgery, Gastrointestinal Surgery, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Gulou District, Nanjing 210029, Jiangsu Province, China. pingxiaochun@jsph.org.cn
Received: August 4, 2020
Peer-review started: August 4, 2020
First decision: September 17, 2020
Revised: September 30, 2020
Accepted: April 29, 2021
Article in press: April 29, 2021
Published online: May 27, 2021
Abstract
BACKGROUND

Ewing sarcomas (ESs) are highly aggressive malignancy and are predominant in the long bones of extremities of children and young adults with a slight male predilection and rarely presents at extra skeletal locations.

CASE SUMMARY

A 55-year-old woman came to our hospital after finding elevated tumor biomarkers during her physical examination. Her enhanced computed tomography scan showed a jejunal mass. The patient underwent laparoscopic enterectomy. The mass was later diagnosed as ES, evidenced by fluorescence in situ hybridization whereby the GLP ES breakpoint region 1 probe was used, showing that more than 10% of the cells showed a red-green-yellow signal proving the breakpoint rearrangement of the ES breakpoint region 1 gene in chromosome 22.

CONCLUSION

We describe a case of localized ES at the jejunum in China based on the literature.

Keywords: Ewing sarcoma, Small bowel, Fluorescence in situ hybridization, Ewing sarcoma breakpoint region 1 gene, Jejunum, Enterectomy, Case report

Core Tip: Ewing sarcomas (ESs) are a highly aggressive malignancy and are predominant in the long bones of extremities of children and young adults. We hereby present a case of extraosseous ES of the jejunum in a female patient. This case highlights the jejunum as a potential site of ES origin and shows that a surgical approach with adjuvant chemotherapy is beneficial.