Liver preservation prior to transplantation: Past, present, and future

Abstract

Since Dr. Thomas Starzl performed the first series of successful liver transplants (LTs), important advances have been made in immunosuppression, operative techniques, and postoperative care. In 1988, Belzer’s group reported the first successful LT using the University of Wisconsin preservation solution (UW). Since then, UW has replaced EuroCollins solution and allowed prolonged and safer preservation of liver, kidney, and pancreas allografts, thus contributing to the improvement of transplant outcomes. Although UW is still considered the standard of care in the United States and in several countries worldwide, a recent meta-analysis revealed similar LT outcomes among UW, Celsior solution, and the Institut Georges Lopez-1 preservation solution, which were slightly superior to those obtained with histidine-tryptophan-ketoglutarate preservation solution. Dynamic preservation has been recently developed, and liver allografts are preserved mainly through the following methods: hypothermic machine perfusion, normothermic machine perfusion, and subnormothermic machine perfusion. Their use has the potential advantage of improving clinical results in LT involving extended criteria donor allografts. Although associated with increased costs, techniques employing machine perfusion of liver allografts have been considered clinically feasible. This editorial focuses on recent advances and future perspectives in liver allograft preservation.

Keywords: Liver transplantation; University of Wisconsin preservation solution; Institute Georges Lopez preservation solution; Celsior preservation solution; Histidine-tryptophan-ketoglutarate preservation solution; Dymamic preservation; Normothermic ischemia; Normothermic preservation; Hypotermic machine preservation; Static cold prreservation

Core tip: Important advances in immunosuppression, operative techniques, and postoperative care have been made in liver transplantation over time. The success of a transplant is largely dependent on adequate organ preservation. This editorial focuses on recent advances in the preservation of liver allografts.