Achieving safe influenza vaccination coverage among pregnant and breastfeeding women is a global health goal due to the potential risks of serious influenza for both mother and child. However, vaccine hesitancy remains a significant barrier to vaccination uptake. Since anxiety represents a determinant in vaccine decision-making, this study aimed to assess influenza vaccination hesitancy and anxiety levels in this population and to explore the association between women's characteristics, their reluctance, and anxiety levels. A multicentre, cross-sectional study was conducted between February and June 2022 using structured phone interviews to assess: (1) socio-demographics and clinical history; (2) anti-flu vaccination status, previous anti-flu vaccination, and Sars-CoV-2 infection history; (3) insights into influenza vaccination during pregnancy; (4) attitudes toward anti-flu vaccination, using the Vaccination Attitudes Examination (VAX) Scale; (5) anxiety levels, measured by the Self-Rating Anxiety Scale (SAS). Among the 387 participants, 22.8% were already vaccinated or expressed willingness to be vaccinated against influenza, and 54% had an anxiety disorder. While anxiety was not significantly associated with vaccine hesitancy, ongoing pregnancy emerged as an independent predictor of anxiety. Higher educational levels, ongoing pregnancy, already being vaccinated or willingness to get vaccinated, and being employed were associated with reduced vaccine hesitancy, while prior SARS-CoV-2 infection with increased hesitancy. Fear of unpredictable events and lack of healthcare professionals' recommendations emerged as reasons for vaccine reluctance. Given the low coverage rates, these findings highlight the need for health services to enhance vaccination efforts and provide clear recommendations to counter misinformation and ensure accurate vaccine safety information.

This study aims to evaluate the effect of a structured family auditory stimulation on preventing ICU delirium among patients with unplanned admissions.

A three-arm parallel, single-blinded, randomized controlled trial was designed.

Patients were randomly assigned to one of three groups: structured family auditory stimulation (Group A), unstructured family auditory stimulation (Group B), and usual care (Group C). The primary outcome was delirium incidence, and secondary outcomes included delirium severity, delirium duration, delirium-free days, delirium subtypes, time to first delirium, the family anxiety and depression levels.

A total of 213 patients were randomly assigned to three groups. There were no significant differences in demographic or clinical characteristics among the three groups. For the primary outcome, fewer patients developed delirium in Group A than in Group B and Group C (22.5 % vs. 26.8 % vs. 49.3 %, P = 0.001). For secondary outcomes, Group A had lower delirium severity scores than the other groups did (3.1 ± 0.4 vs. 4.0 ± 0.3 vs. 5.1 ± 0.3, P < 0.001). Patients in Group A had shorter delirium durations (2.0 vs. 3.0 vs.4.0 days, P < 0.001) and longer delirium-free days (3.0 vs. 2.0 vs. 1.0 days, P < 0.001) than those in Group B and Group C. The time to first delirium was 3.0, 2.0, and 2.0 days, respectively (P < 0.001). The SAS scores of the families in the three groups were 47.1 ± 5.7, 48.9 ± 5.5, and 56.5 ± 7.5 (P < 0.001) and the SDS scores were 38.2 ± 5.8, 38.3 ± 5.7, and 42.7 ± 7.2 (P < 0.001).

The results revealed that structured family auditory stimulation could reduce delirium incidence, decrease its severity, shorten the duration of delirium, increase delirium-free days, and prolong the time to first delirium among ICU patients with unplanned admission. Additionally, it could alleviate families' anxiety and depression levels.

Structured family auditory stimulation prevents ICU delirium by maintaining the patients' cognitive function and promoting early recovery, showing significant clinical potential in ICU delirium.

To identify and evaluate risk factors for psychiatric disorders in pediatric patients with tuberous sclerosis complex (TSC).We recruited 121 children with TSC from the Hangzhou Children's Hospital between April 2021 and December 2023. Four clinical psychiatric scales were used to screen and diagnose the psychiatric comorbidities of TSC: the autism behavior checklist, the SNAP-IV scale, and the self-rating anxiety and depression scales. Risk factors related to each psychiatric disorder were analyzed using univariate and multivariate regression analyses.Comorbid psychiatric disorders were found in 70 (57.85%) children: 51 (42.15%) cases had autism spectrum disorder (ASD), 49 (40.50%) cases had attention-deficit hyperactivity disorder (ADHD), 17 (14.05%) cases had anxiety, and 14 (11.57%) cases had depression. Uni- and multivariate logistic regression analysis revealed that seizure frequency (>1/month; OR = 6.206, P = 0.021), use of anti-seizure medications (≥ 2 types; OR = 118.869, P = 0.003), infantile spasms (OR = 25.748, P = 0.000), ADHD (OR = 11.170, P = 0.001), and intellectual disability (OR = 32.131, P = 0.001) were risk factors for TSC children with ASD; ASD was the only risk factor for occurrence of ADHD (OR = 7.302, P = 0.022). Seizure duration (≥ 2 years; OR = 56.200, P = 0.036) and seizure frequency (>1/month; OR = 25.855, P = 0.027) were closely related to occurrence of anxiety and/or depression disorders in pediatric patients with TSC.The study results showed that psychiatric comorbidities of children with TSC had a high incidence and risk factors. The study provides new insights into the diagnosis and treatment of comorbid psychiatric disorders in pediatric patients with TSC.

We aimed to explore the application effects of humanistic nursing combined with Neuman's nursing in oncology patients.

One hundred oncology patients were randomly divided into the observation and control groups, with 50 patients in each. Comparisons were made between both groups in terms of SF-36 scores, treatment compliance, nursing quality scores, Self-Rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) scores, and Pittsburgh Sleep Quality Index (PSQI) scores.

The observation group showed higher scores in the physical domain, physiological function, material life, and overall health of the SF-36 scale (P < 0.05). The observation group also exhibited higher treatment compliance rate (X² = 9.470), and higher scores in nurse-patient communication, nursing system, nursing service, and nursing environment of the nursing quality assessment (P < 0.05). After nursing, the observation group performed lower SAS and SDS scores (t = 17.556, 10.004), and higher scores in sleep quality, sleep duration, sleep disturbance, sleep onset latency, sleep efficiency, hypnotic medication use, and daytime dysfunction based on the PSQI (P < 0.05).

The combination of humanistic nursing and Neuman's nursing improves the quality of life and treatment compliance in oncology patients, with improvements in negative emotions and sleep quality. However, this study's small sample of 100 cancer patients may not fully represent the diverse characteristics of various cancer types and stages, limiting conclusion generalizability. Furthermore, the short duration may have missed later-stage nursing intervention impacts. Thus, large-scale, long-term research is needed to provide reliable clinical evidence.

This review aims to investigate the issue of treatment nonadherence and to present the available strategies to improve adherence to oral treatments in breast cancer. A literature search was conducted to contextualise the issue of nonadherence, investigate the reasons behind nonadherence, and demonstrate strategies to address treatment nonadherence in breast cancer. Findings indicate that adherence rates decrease while discontinuation rates increase with increasing lengths of breast cancer treatment course. Lack of adherence is proven to be detrimental to treatment outcomes. Patients struggle to adhere to treatment due to inadequate relationships with healthcare providers, lack of information, psychological distress, and side effects. Healthcare providers should evaluate patient's experience to provide the necessary support. Following this assessment, healthcare providers may recommend interventions addressing patient knowledge, psychological distress or side effects. Treatment adherence remains an issue for oral therapeutics in breast cancer. After patient assessment, healthcare providers can offer personalised strategies to improve treatment adherence. The most crucial interventions address patient knowledge, psychological distress, and side effects.

Post-dural puncture headache (PDPH) is a common complication of diagnostic lumbar puncture (LP), often leading to extended hospitalization and additional medication use. Clinical studies have shown that anodal transcranial direct current stimulation (a-tDCS) is effective against migraine, and thus we decided to assess whether a-tDCS was also effective in treating and preventing PDPH.

In two independent, randomized, monocentric controlled trials (RCTs), we enrolled 97 hospitalized participants who underwent LP for diagnostic purposes. Patients were randomized to receive either active a-tDCS or sham tDCS over the dominant primary motor cortex (M1) in a therapeutic tDCS (Th-tDCS) or preventive tDCS (Pr-tDCS) study. In the two trials, the primary outcome was the severity of PDPH measured using the Visual Analogue Scale (VAS) for pain. Secondary outcomes included the Brief Pain Inventory (BPI) to evaluate other pain-related symptoms associated with LP.

In the Th-tDCS study, significant differences between groups were observed after tDCS in the VAS (F = 17.011, p < 0.001), as well as in BPI intensity (F = 17.006, p < 0.001) and BPI interference (F = 14.730, p < 0.001). Moreover, in the Pr-tDCS study, VAS analysis showed a significant time × group interaction (F = 6.918, p = 0.002). Significant differences were also observed in BPI intensity (F = 17.866, p < 0.001) and BPI interference (F = 15.520, p < 0.001).

Our findings suggest that a-tDCS may effectively prevent and treat PDPH and alleviate other pain-related symptoms associated with LP. Encouraging results have emerged for the use of a-tDCS in patients undergoing LP, in both experimental research designs (Th-tDCS and Pr-tDCS). A non-invasive brain stimulation (NIBS) technique, such as a-tDCS, could have a therapeutic and preventive effect on pain resulting from a LP.

ClinicalTrials.gov (ID: NCT06640634) retrospectively registered on October 8, 2024.

Postoperative nausea and vomiting (PONV) is a common complication following surgery. Despite various preventive measures, satisfactory outcomes have not been achieved. This study explores the potential of gut microbiota interactions with the host in understanding and preventing PONV, using 16S absolute quantitative sequencing technology to uncover new insights.

Patients who experienced nausea and vomiting within 24 h after surgery were divided into a PONV group (n = 22) and a non-PONV group (n = 22). Microbial communities linked to PONV were assessed through bioinformatics analysis. Fecal samples from both groups were transplanted into rats, which were then anesthetized with isoflurane for 100 min. Pica behavior was monitored over the next 24 h to assess nausea and vomiting in the rats.

Significant differences in α- and β-diversity were observed between the PONV and non-PONV groups. Six key microorganisms were identified, with Bifidobacterium, Bilophila, and Oscillibacter showing a negative correlation with PONV severity. Receiver operating characteristic (ROC) analysis demonstrated that Bifidobacterium could reliably predict PONV. Rats receiving feces from the PONV group exhibited significantly higher kaolin consumption within 24 h post-anesthesia compared to those receiving feces from the non-PONV group.

These results suggest a potential new mechanism for PONV involving gut microbiota, offering a theoretical basis for preoperative prediction of PONV based on gut microbial composition.

Home enteral nutrition (HEN) is a reliable and effective intervention. However, the impact of HEN on the changes in quality of life (QoL) over time remains unexplored. We aimed to investigate changes in QoL, emotional well-being, and functional status over time and identify the factors associated with QoL in patients requiring HEN.

We retrospectively analyzed the data of 288 patients requiring HEN who were discharged from the Clinical Nutrition Therapy Center of a tertiary care teaching hospital in China between December 1, 2014, and April 31, 2024. Data on demographics, laboratory analysis results, bioelectrical impedance analysis results, physical function, emotional status, and QoL were retrieved from a prospectively maintained database.

Patients requiring HEN had QoL scores of 52.83 ± 14.01, 54.11 ± 14.79, and 56.78 ± 14.29 at discharge, 3-month follow-up, and 6-month follow-up, respectively. The Short Form 36 scores increased by 0.66 points per month (95% confidence interval [CI] 0.40-0.91; P < 0.05), whereas the Karnofsky Performance Scale (KPS) scores increased by 2.56 points per month (95% CI: 2.38-2.75; P < 0.05). The Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) declined by 1.33 (95% CI: -1.46 to -1.21; P < 0.05) and 0.38 (95% CI: -0.57 to -0.20; P < 0.05) points, respectively, each month. Multivariate analysis identified that complications (β = 7.191; P < 0.001), SAS (β = -0.135; P = 0.029), SDS (β = -0.293; P < 0.001), and KPS (β = 0.126; P = 0.003) were factors associated with QoL.

QoL improved continuously among patients receiving HEN; however, it remained suboptimal. Healthcare providers should offer comprehensive, continuous, and dynamic support to help patients reintegrate into their social lives.

Physical activity plays a crucial role in promoting health, notably in mitigating anxiety symptoms. However, limited research has explored how different intensities of physical activity uniquely influence anxiety. This study investigated the dose‒response relationship between Chinese adolescents' 24-h activity behavior and anxiety symptoms using compositional data analysis (CoDA).

The temporal distribution of 24-h activity behaviors of 176 adolescents was objectively measured by accelerometers, and anxiety symptoms were assessed by the Self-Rating Anxiety Scale (SAS). Data were analyzed using CoDA and the isotemporal substitution model to statistically modify the intensity and duration of exercise in predicting anxiety.

Moderate-to-vigorous physical activity (MVPA), but not light physical activity (LPA), was negatively associated with adolescent anxiety symptoms; SB, SP and anxiety symptoms were positively inter-correlated. Isotemporal substitution analyses indicated that replacing 15 min of other activities with MVPA, or substituting SB with LPA, reduced anxiety symptom levels; conversely, the opposite substitutions increased it. Dose-effect analysis showed that the reallocation between LPA and SB had an equivalent but opposite impact on anxiety symptom levels. Meanwhile, When replacing other activities with MVPA, anxiety levels decreased slowly; when MVPA was replaced by other activities, anxiety levels increased rapidly.

MVPA is a key factor in alleviating anxiety symptoms, but it is essential to consider adolescents' 24-h activity behaviors holistically. The primary goal should be to maintain existing levels of MVPA while reasonably promoting the replacement of SB with MVPA, thereby enhancing adolescents' physical and mental health.

Sleep disorders are a common symptom in Ankylosing Spondylitis (AS) patients. In this cross-sectional study, we aimed to understand the current status of sleep disorders in AS patients and to analyze potential factors influencing sleep disorders.

A total of 205 AS patients were recruited in the survey. The content included the self-designed demographic data questionnaire, The MOS 36-Item Short Form Health Survey (SF-36), Visual Analogue Scale (VAS), Multidimensional Fatigue Inventory (MF-20), Self-Rating Anxiety and Depression Scale, Pittsburgh Sleep Quality Index questionnaire (PSQI), Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI) and Bath Ankylosing Spondylitis Metrology Index (BASMI). These data were analyzed using chi-square test, independent sample t-test, Mann-Whitney U test, Pearson correlation analysis, single-factor linear regression analysis, and multiple linear stepwise regression analysis.

The results showed that the average sleep total score was 8.82 ± 4.146, and the prevalence of sleep disorders was approximately 66.8% in AS patients. Age (F = 29.710, P < 0.001), disease duration (F = 13.025, P < 0.001), anxiety (F = 36.060, P < 0.001), depression (F = 11.808, P < 0.001), and quality of life (t = 6.665, P < 0.001) significantly impacted the sleep total score. Pearson correlation analysis revealed a significant negative correlation between SF-36 total score and sleep total score (r = ‒0.449, P < 0.01), while positive correlations were observed for VAS score, fatigue, anxiety, depression, BASDAI, BASFI, BASMI, age, and disease duration (all P < 0.01). Multivariate analysis showed that age, disease duration, nocturnal pain VAS score, total back pain VAS score, peripheral joint pain VAS score, total fatigue score, total anxiety score, and BASMI total score significantly predicted sleep total score (R² = 0.755, F = 45.334, P < 0.001).

These findings suggest that medical professionals should pay increased attention to the observed associations between sleep disorders and clinical factors in AS patients, and consider implementing targeted interventions to address sleep-related issues.

To evaluate the influence of engaging in Baduanjin exercise on pulmonary function, quality of life (QoL), mental well-being and exercise tolerance among postoperative individuals diagnosed with non-small cell lung cancer (NSCLC).

A comprehensive search of randomized controlled trials (RCTs) in eleven different electronic databases, spanning from their inception up until July 3, 2024, was conducted. Following this exhaustive search, the literature was thoroughly screened, relevant information was carefully extracted, and the potential for bias within the selected studies was critically evaluated by two independent researchers. Employing Revman 5.4 software, statistical analyses were then carried out.

A comprehensive compilation of 6 RCTs, involving a collective 540 patients diagnosed with NSCLC, was analyzed. The pooled findings revealed that engaging in Baduanjin exercise leads to a significant enhancement in forced vital capacity (FVC) (WMD=0.23, 95% CI=0.06 ∼ 0.41, P = 0.009), forced expiratory volume in the first second (FEV1) (WMD=0.16, 95% CI=0.00 ∼ 0.32, P = 0.05) in NSCLC patients, as well as QoL (WMD=24.09, 95% CI=20.68 ∼ 27.51, P<0.00001) and functional well-being (WMD=6.70, 95% CI=5.50 ∼ 7.90, P < 0.00001). Meanwhile, Baduanjin exercise reduced Self-Rating Anxiety Scale (SAS) (WMD=-9.58, 95% CI=-10.58 ∼ -8.58, P < 0.00001) scores in patients with NSCLC. However, sensitivity analyses revealed that the results for physical well-being, social/family well-being, emotional well-being, lung cancer subscales, Self-Rating Depression Scale (SDS) scores, and 6 min walk distance (6MWD) lacked robustness. Subgroup analysis was conducted based on the intervention frequency, revealed that both 3 and 10 weekly training sessions improved 6MWD in NSCLC patients. Notably, 10 weekly training sessions (WMD=54.72, 95% CI=28.76 ∼ 80.69, P<0.0001) were found to be twice as effective as 3 weekly training sessions (WMD=26.96, 95% CI=17.31 ∼ 36.61, P<0.00001) in enhancing 6MWD . However, no improvement in 6MWD was observed in the 8 weekly training sessions (WMD=-18.34, 95%CI=-41.55 ∼ 4.87, P<0.00001).

The meta-analysis revealed that for individuals diagnosed with NSCLC, Baduanjin exercise demonstrated significant effectiveness in terms of pulmonary function enhancement, QoL elevation, anxiety alleviation and exercise endurance improvement. However, the methodological limitations significantly constrain the strength of clinical evidence. Meanwhile, the lack of robustness in some outcomes as indicated by sensitivity analyses, suggest significant constraints in the external validity and generalizability of the findings to broader populations.

Knee osteoarthritis (OA) is a common chronic condition among the elderly, leading to a decline in OA patients' quality of life. This study aimed to investigate the relationship between radiographic severity and health-related quality of life (HRQoL) in elderly women with knee OA.

A total of 80 elderly women with knee OA were enrolled in this study. Radiographic severity was assessed with the Kellgren-Lawrence (K/L) scale, we divided the subjects into early (1-2) and late (3-4) according to the K/L stage. HRQoL assessment was conducted using the MOS item Short-Form 36 (SF-36). The association of HRQoL with knee OA severity was estimated using logistic regression. Applied a random forest model to assess the importance and accuracy of relevant variables in the occurrence of OA. The LASSO (Least Absolute Shrinkage and Selection Operator) regression was then used to identify key factors associated with OA, which were incorporated into the development of a risk prediction nomogram model. Furthermore, a receiver operating characteristic (ROC) curve was constructed to evaluate the model's discriminative ability for OA.

The mean age of the patients was 64.7 ± 6.74 years, and the mean course of disease was 5.01 ± 2.12 years. HRQoL score (SF-36 PCS and MCS) was significantly worse in the late-stage group compared to the early group (p < 0.05). The late group K/L scale has a negative correlation with SF-36 PCS (r = -0.598) and MCS (r = -0.625) and a strong positive correlation. In logistic regression analysis, the K/L scale were significantly associated with SF-36MCS (OR = 0.86, p = 0.041), SF-36 PCS (OR = 0.85, p = 0.025) and TUG (OR = 1.80, p = 0.001). The nomogram model based on key OA risk factors identified by LASSO regression demonstrated substantial predictive value for OA, with an area under the curve (AUC) of 72.2%.

The radiographic severity of knee OA was correlated with health-related quality of life. The HRQoL is an important predictive indicator of the severity of knee OA severity, which might provide beneficial management and treatment for patients with knee OA.

BackgroundDrug treatment of refractory irritable bowel syndrome (IBS) is not satisfactory at present. This study investigated the clinical effects of ebastine combined with low-dose antidepressants on refractory IBS.MethodsA total of 105 patients with refractory refractory IBS were randomly assigned to two different treatment groups after signing informed consent. And they didn't know about the treatment group they were in. They were administered with ebastine (Group A) or ebastine combined with flupentixol and melitracen (Group B) for 4 weeks. Drug efficacy was evaluated using scales before and after treatment. In addition, serum D-lactate (D-LAC) and human intestinal fatty acid binding protein (I-FABP) level were measured to assess intestinal permeability.ResultsSignificant improvements were observed in IBS Quality of Life (IBS-QOL) score, IBS Symptom Severity Scale (IBS-SSS) score, and total sleep quality score. Patients in Group A showed no improvements in anxiety (44.83 ± 9.62 vs. 43.92 ± 10.43, P = 0.415) and depression (39.08 ± 9.34 vs. 38.75 ± 9.35, P = 0.674) compared with the baseline level, while those in Group B improved significantly on anxiety (52.12 ± 8.19 vs. 39.28 ± 9.88) and depression (47.64 ± 9.53 vs. 38.24 ± 9.41) status. After treatment, the serum levels of D-LAC and I-FABP were significantly lower in Group B than in Group A.ConclusionRefractory IBS patients showed certain psychological abnormalities. Ebastine combined with antidepressants exhibited more obvious benefits on QOL, sleep quality, and SSS, with significant improvements in psychological status and intestinal permeability in refractory IBS patients.

Gastrointestinal symptoms are closely associated with psychological problems, such as anxiety and depression. This prospective before-after study aimed to explore whether progressive muscular relaxation training combined with music intervention, which is potentially beneficial for psychological conditions, can improve gastrointestinal symptoms.

A total of 623 recruits' effective questionnaires before and after intervention were collected. They underwent progressive muscular relaxation training combined with music intervention for 4 weeks. They also completed the Self-Rating Depression Scale (SDS) and the Patient Health Questionnaire (PHQ-9) for assessment of depression, the Self-Rating Anxiety Scale (SAS) and the Generalized Anxiety Disorder-7 (GAD-7) for assessment of anxiety, the Gastrointestinal Symptom Rating Scale (GSRS) for assessment of gastrointestinal symptoms, and the Bristol Stool Form Scale (BSFS) for assessment of stool before and after interventions. Changes of psychological conditions and gastrointestinal symptoms were evaluated.

The SDS (P<0.001), PHQ-9 (P<0.001), SAS (P<0.001), GAD-7 (P<0.001), and GSRS (P<0.001) scores were significantly decreased after intervention. The proportions of regurgitation (P<0.001), abdominal pain (P<0.001), dyspepsia (P<0.001), and constipation (P<0.001) evaluated by the GSRS were significantly decreased after intervention, but not diarrhea (P=0.601). The proportions of severe (P<0.001) and mild (P<0.001) constipation evaluated by the BSFS decreased after intervention, but those of severe (P=0.632) and mild (P<0.001) diarrhea evaluated by the BSFS increased.

Short-term progressive muscular relaxation training in combination with music intervention is potentially effective for most gastrointestinal symptoms, but not for diarrhea, in recruits.

A systematic evaluation and network meta-analysis (NMA) using randomized controlled trials (RCTs) was conducted to investigate the effects of different exercise intensities and dosages on the mental health of college students.

A systematic search of eight electronic databases of RCTs involving mental health exercise interventions for college students was conducted, which included data from the inception of the databases through July 2024. Two independent reviewers assessed the quality of the literature. Pairwise, network, and dose‒response meta-analyses were conducted via random-effects models to analyze the effects of exercise on college students' mental health.

A total of 48 RCTs (3951 patients) were included. Light, moderate, and vigorous exercise were all significantly effective at reducing symptoms of depression, anxiety and stress, whereas very light exercise was only effective at reducing symptoms of depression and stress. Surface under the cumulative ranking curve (SUCRA) probability ranking revealed that vigorous exercise had the highest probability of being the best intervention intensity to improve depression and stress symptoms, and the best exercise intensity to improve anxiety symptoms was moderate. The minimum threshold for overall exercise intervention for depressive symptoms was 150 METs-min per week, the benefits provided after doses above 1300 METs-min per week were less pronounced, and the predicted maximum significant response dose was 860 METs-min per week, which was the same as the predicted data for moderate exercise.

Very light, light, moderate, and vigorous exercise are all potentially effective exercise intensities for improving the mental health of college students, with no significant difference in effectiveness across the four exercise intensities. SUCRA rankings revealed that vigorous exercise is the most effective intervention for depression and stress and that moderate exercise is the most effective intervention for anxiety. Exercise interventions for depressive symptoms have a low dosage threshold, are simple and easy to administer, and are good treatments for psychological problems in college students.

Objective: Face recognition is an important cognitive function of the human brain. Post stroke depression (PSD) is a common mental complication after stroke, which has a serious impact on individual physical function recovery and quality of life. This study aims to explore the face perception characteristics of PSD through electrophysiological indicators N170 and VPP, and provide an objective basis for the early evaluation of facial cognitive dysfunction in PSD. Methods: 58 patients in the cerebral small vessel disease (CSVD) with depressive symptoms (PSD) and 188 patients in the pure CSVD (NPSD). At the same time, 30 healthy subjects were selected as the healthy controls (HC). The differences of N170 and VPP components between the three groups were compared under the stimulation of inverted faces and upright faces. Results: PSD patients exhibited significantly longer peak latency and lower amplitude of N170 and VPP under both inverted and upright face stimulation compared to HC and NPSD. These results suggest that PSD patients have defects in early face recognition, there are abnormalities in the early perception and structural encoding of face information, and both the "overall mechanism" and "feature mechanism" of face recognition are damaged. Conclusions: These findings provide neuroelectrophysiological evidence for impaired emotionless face recognition in PSD patients.

The COVID-19 pandemic caused by the SARS-CoV-2 virus is one of the most significant public health emergencies of this century. The rapid outbreak of COVID-19 infections has instilled fear in populations. Therefore, it is essential to investigate the risk factors and mechanisms associated with fear of progression (FoP) among individuals recovering from COVID-19. This information is crucial for alleviating the physical and psychological discomfort of individuals after recovery and enhancing their long-term quality of life.

A cross-sectional study involving 861 individuals recovering from COVID-19 was conducted in China from January to February 2023. The Pittsburgh Sleep Quality Index, the Self-Rating Depression Scale, the Self-Rating Anxiety Scale, and the Fear of Progression Scale were utilized to assess mood status, sleep quality, and fear of progression. Receiver operating characteristic curves, Pearson's correlation analysis, binary logistic regression analysis, and Hayes' PROCESS Macro analysis were employed to test the model.

The results showed that sleep quality, anxiety, depression, and fear of progression were positively correlated, with coefficients ranging from 0.380 to 0.814. After addressing potential bias, sleep quality, anxiety, and depression emerged as risk factors for fear of progression (FoP). In the ROC curve analysis, these three factors predicted the occurrence of FoP (AUC: 0.646, 0.703, and 0.658, respectively). Anxiety and depression played a parallel mediating role between sleep quality and FoP, accounting for 59.9 and 13.8% of the total effect, respectively.

The results indicate that anxiety and depression both serve a parallel mediating role in the relationship between sleep quality and fear of pain (FoP). These findings provide potential guidance for the development and implementation of group-based interventions to address the mental health challenges of the post-COVID-19 era.

This study aimed to explore the impact of precision nursing intervention based on Damage Control Orthopedics (DCO) model on joint function and quality of life of elderly hip arthroplasty patients.

Elderly hip arthroplasty patients (n = 100) who underwent hip replacement surgery at our hospital from January 2023 to June 2024 were collected and randomly assigned into two groups, with 50 patients in each. The control group received conventional nursing intervention, while the observation group received precision nursing intervention based on the DCO model. The hip joint function (Harris), Self-rating Depression Scale (SDS), Self-rating Anxiety Scale (SAS), Pittsburgh Sleep Quality Index (PSQI), Barthel Index (BI), and SF-36 were employed to assess hip joint function, psychological status, sleep quality, daily living abilities, and quality of life before and after intervention in both groups. Complications in both groups were also recorded.

Compared to pre-intervention, the hip joint function scores and BI scores in both groups significantly improved post-intervention, with the observation group scoring higher than the control group (P < 0.05). After the intervention, SAS, SDS, and PSQI scores decreased in both groups, with the observation group showing lower scores than the control group (P < 0.05). The quality of life scores in the observation group post-intervention were higher than those in the control group (P < 0.05).

Precision nursing intervention based on DCO model can significantly improve joint function and quality of life in elderly patients with hip arthroplasty.

With diminished ovarian reserve (DOR) becoming increasingly younger in women, age-related fertility decline in females is gradually becoming one of the most important factors affecting female fertility. The purpose of the study is to assess whether acupuncture can successfully relieve the age-related decline in female fertility. This will provide substantial proof in support of the therapeutic effectiveness of acupuncture.

This is a randomized, double-blind, controlled trial. There will be 108 participants diagnosed with DOR recruited in China. Participants will be randomly assigned in a 1:1 ratio to two groups, including acupuncture and sham acupuncture groups. The participants will receive acupuncture treatments three times a week, each lasting 30 minutes, for 36 weeks. The primary outcome was the change in ovarian function modeling as assessed by four metrics: age, ovarian reserve markers such as follicle-stimulating hormone (FSH) and anti-Müllerian hormone (AMH) in the Ovarian Reserve Function Prediction Tool (OvaRePred). Secondary outcomes will include changes in the antral follicle count (AFC), serum sex hormone levels, Zung's Self-rating Anxiety Scale (SAS), and the Self-rating Depression Scale (SDS). Adverse events (AEs) associated with acupuncture will be documented following each treatment session. AEs will be monitored and reported to ensure patient safety throughout the trial.

We will be able to measure the effectiveness of acupuncture for patients with DOR and whether acupuncture is superior to sham acupuncture. The proposed acupuncture treatment might provide an alternative option for those patients.

ChiCTR2400086376.

There is extensive awareness of internet pornography addiction. It not only affects the mental health of adolescents but also promotes criminal activity. However, the impact of internet pornography addiction on functional in the brain remains unclear.

16 healthy college students and five college students with severe internet pornography addiction were invited to participate in the experiment and watch a pornographic video. Functional near-infrared spectroscopy (fNIRS) was used to measure the dynamic changes in hemoglobin in the brain during a 10 min session of viewing internet pornography. Participants completed the Stroop Color and Word Task (SCWT) before and after they had watched the video. Facial expressions and life signs were measured continuously during the experiment.

Compared with the group that frequently viewed pornographic videos, the group with low-frequency pornography viewing exhibited enhanced functional connectivity in the inferior prefrontal cortex and pars triangularis of Broca's area in the frontal lobe, the primary somatosensory cortex in the parietal lobe, and the pre-motor and supplementary motor cortices. Moreover, the high-frequency pornography-viewing group exhibited hyperactive parasympathetic activity, more pronounced sexual arousal, and stronger functional connectivity in the dorsolateral prefrontal cortex and frontopolar area. After viewing the pornography, the high-frequency group demonstrated longer reaction times and significantly reduced accuracy while completing the Stroop Color and Word Test (SCWT) compared to the low-frequency group and also their own performance before and after viewing the pornography.

This study demonstrated the hyperactive and inhibited brain areas under the impact of pornography video addiction. The results may strengthen our understanding of neurobiology and facilitate the development of prevention policies for adolescents.

This study aims to explore the central mechanisms of shallow acupuncture for chronic neck pain (CNP) using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI), an innovative approach not commonly applied in shallow acupuncture research.

This multi-center randomized controlled trial will recruit 252 CNP patients from three centers (84 per center). Participants will be randomly assigned to three groups: shallow acupuncture, drug control (celecoxib capsules), or waiting list group, with 84 patients per group. The primary outcomes include total effective rate, visual analogue scale (VAS), Neck Disability Index (NDI), and brain imaging results (20 randomly selected patients per group). Secondary outcomes include the Self-Rating Anxiety Scale (SAS), Short Form 36 Questionnaire (SF-36), and cervical range of motion (CROM). Data will be collected at baseline, after 2 weeks, and at 3-month follow-up. fMRI and DTI data will be collected at baseline and after 2 weeks. Analyses will include regional homogeneity (ReHo), amplitude of low-frequency fluctuations (ALFF), functional connectivity (FC), fractional anisotropy (FA), and mean diffusivity (MD) within and between groups. An additional 20 healthy volunteers will provide baseline fMRI and DTI data for comparison.

This study will validate the clinical efficacy of shallow acupuncture for CNP and explore its central mechanisms using fMRI and DTI. The findings may provide neuroimaging evidence supporting the broader clinical application of shallow acupuncture in treating CNS-related diseases.

Pregnancy leads to vulnerabilities and susceptibilities to mental disorders. Miscarriage, as an adverse pregnancy outcome, and following curettage for treatment, add the risks of further psychiatric disorders, including depression, anxiety, insomnia, etc., and current approaches to prevention are unsatisfactory. Ketamine and its S-enantiomer esketamine can prevent postpartum depression, and esketamine even treats depressive symptoms after miscarriage curettage, but their side effects bring limitations. Ascorbic acid (AA, Vitamin C) can modulate mood and enhance ketamine's antidepressant efficacy synergistically, reducing its dosages and adverse effects potentially. The purpose of this study is to clarify the beneficial modification of AA on esketamine for preventing depression and other mental disorders in patients with miscarriage after painless curettage, as well as the interaction between AA and esketamine.

This study is a 2×2 factorial, double-blinded, randomized, controlled trial that will recruit women with miscarriage undergoing painless curettage. A total of 424 participants will be recruited and randomly 1:1:1:1 allocated to the following four groups (106 in each): Group A0K0 (normal saline and normal saline), Group A0K1 (normal saline and esketamine), Group A1K0 (AA and normal saline), and Group A1K1 (AA and esketamine). The primary outcome is the incidence of depression on postoperative day 7, assessed with the Edinburgh Postnatal Depression Scale (EPDS). The secondary outcomes include the EPDS score, assessments of anxiety, sleep, and pain, adverse events, perianesthetic data and patient satisfaction.

This study provides the clinical trial-based evidence of the effects of AA alone or in combination/interacting with the emerging rapid-acting antidepressant esketamine on depression and other mental disorders in patients with miscarriage undergoing painless curettage. Our data are expected to suggest AA's potential application for optimizing strategies of promoting post-miscarriage mental health, and its possible adjunctive improvement of (es)ketamine's usage as antidepressants. One major limitation is that this study is a single-center study, and the results might be biased due to regional factors.

Posture management significantly influences the natural childbirth process and the maternal experience. The aim of this study is to analyze the effects of the lateral recumbent position versus the kneeling prone position combined with unprotected perineal delivery in natural childbirth, providing evidence-based support for clinical maternal care and posture management.

This research constitutes a retrospective cohort investigation, encompassing a period from January 2022 to December 2023, and focusing on women in labor who experienced childbirth at our medical facility. The study meticulously assessed and compared the characteristics and clinical outcomes of those who adopted the lateral recumbent position with those who utilized the kneeling prone position during the process of natural childbirth.

A total of 168 women in labor were included, 86 women in labor underwent lateral recumbent position and 82 women in labor underwent kneeling prone position for natural childbirth. There were no statistical differences in first, second, third and total stage of labor between lateral recumbent position group and kneeling prone position group were found (all P > 0.05). Visual Analogue Scale (VAS) and Self-Rating Anxiety Scale (SAS) score after labor in lateral recumbent position group were statistically lower than that of kneeling prone position group(all P < 0.05). The lateral recumbent position reduced the likelihood of episiotomy and perineal edema, the severity of perineal lacerations compared with kneeling prone position for natural childbirth (all P < 0.05).

Lateral recumbent position in natural childbirth offers the advantage of reducing perineal trauma, alleviating maternal pain and anxiety, and may be therefore deemed worthy of utilization in clinical maternal care.

To investigate the effect of nonpharmacological methods on anxiety before breast surgery, using the meta-analysis method.

A meta-analysis.

Nine electronic databases were searched to identify studies published up to October 2023. The study was carried out in accordance with Preferred Reporting Items for Systematic Review and Meta-analyses 2020 and Cochrane 2021 recommendations. The Risk of Bias 2 tool was used to assess the risk of bias. Heterogeneity and publication bias were also assessed.

A search of 9 electronic databases identified 280 records. Six studies that met the inclusion criteria were eligible for meta-analysis. All the trials explained how the randomization was done. The studies selected were published between 2016 and 2022. A total of 519 female patients were included in the selected trials, 303 in the intervention group and 216 in the control group. The studies included aromatherapy, music, electro-acupuncture, and Yokukansan Kampo medicine practices. A meta-analysis was performed with anxiety levels measured immediately before surgery. In addition, a subgroup analysis was performed with trials that used anxiety-specific scales before surgery and trials that used aromatherapy.

The results of this meta-analysis indicated a moderate efficacy of nonpharmacological approaches, whereas aromatherapy showed a relatively lower efficacy in reducing preoperative anxiety in breast surgery patients.

(1) Background: This study compares the immediate effects of Rest Redistribution Training (RR) and Traditional Set Structure Training (TS) on vertical jump performance, heart rate variability (HRV), and perceived exertion (RPE) in anxious female college students. (2) Methods: In a randomized experimental design, 14 anxious female college students (ages 18-25, screened via Zung's Self-Rating Anxiety Scale (SAS) with scores ≥50) underwent a familiarization session followed by two trials involving either a RR or TS conditioning routine. Vertical jump, HRV, and RPE were measured pre- and post-session, and during training, respectively. (3) Results: Both protocols induced significant decrements in squat jump (SJs) and countermovement jump (CMJs) metrics (p < 0.05), but no statistically significant between-group differences emerged (p > 0.05; SJ height: d = 0.059, 95% CI [-0.05, 0.05]; CMJ peak power: d = 0.253, 95% CI [-0.02, 0.02]). TS induced significant decreases in time-domain HRV indices (SDNN: d = 0.888, 95% CI [1.07, 16.13; RMSSD: d = 1.511, 95% CI [8.87, 27.63]) and high-frequency power (HF: d = 0.788, 95% CI [2.73, 379.71]), whereas RR preserved these indices. RR significantly reduced RPE compared to TS (p < 0.05; barbell bench press: d = 1.132, 95% CI [0.28, 1.48]; leg press: d = 0.784, 95% CI [0.01, 1.31]). (4) Conclusions: RR and TS protocols induced comparable decrements in vertical jump performance among untrained anxious female college students under equivalent loads; however, RR demonstrated superior autonomic regulation, reduced perceived fatigue, and equivalent performance outcomes, highlighting its potential as a low-stress alternative to traditional resistance training for anxiety-prone populations.

There have been more previous studies on sleep quality and anxiety symptoms among university students in plains areas. However, fewer studies have been conducted on Tibetan university students at high altitude. Analyzing the relationship between sleep quality and anxiety symptoms due to increased altitude may provide a reference for mental health promotion and intervention for Tibetan university students in high altitude areas.

Stratified whole cluster sampling was used. The pittsburgh sleep quality index (PSQI) scale was used to investigate the sleep quality of 4,777 university students at high altitude in China. The self-rating anxiety scale (SAS) was used to investigate anxiety symptoms. The chi-square test was used to compare the detection rates of anxiety symptoms among different groups, and logistic regression analysis was used to analyze the association between sleep quality and anxiety symptoms.

The prevalence of anxiety symptoms among Tibetan university students at high altitude in China was 25.7%. The detection rate of anxiety symptoms among girls (28.4%) was higher than that of boys (22.1%), and the difference was statistically significant (χ 2 = 24.634, p < 0.001). The detection rates of anxiety symptoms among university students with sleep quality of "Good," "Medium" and "Poor" were 1.8, 4.8 and 39.2%, respectively, and the differences were statistically significant (χ 2 = 779.759, p < 0.001). Logistic regression analysis after adjusting for relevant covariates showed that the risk of anxiety symptoms was higher in the "Medium" (OR:3.479, 95%CI:1.946 ~ 6.221) and "Poor" (OR:44.817, 95%CI:29.175 ~ 68.847) groups, compared with the "Good" group. The same trend was observed in both men and women at the university level.

There is a close relationship between sleep quality and the occurrence of anxiety symptoms among Tibetan university students at high altitude in China. Improving sleep quality may have a positive effect on reducing the occurrence of anxiety symptoms among Tibetan university students at high altitude.

Teachers are more likely to experience mental health issues than the general population, yet few studies focus on Chinese teachers. After the "Double Reduction" policy, teacher workload and stress have risen significantly. In Dongguan, a city actively implementing educational reforms, teacher mental health may be particularly concerning. Anxiety, depression, and burnout are prevalent mental health issues. This study examined the prevalence and factors linked to anxiety, depression, and burnout among Dongguan teachers.

A cross-sectional survey evaluated the mental health of primary and secondary school teachers in Dongguan, China, using two-stage random sampling. Eleven schools were randomly selected, with 30 teachers chosen from each of 330 invited participants, 313 completed the survey (94.8% response rate), and 259 valid responses were retained after excluding incomplete or inconsistent answers. The study used the Zung Self-Rating Anxiety Scale (SAS), Zung Self-Rating Depression Scale (SDS), and Maslach Burnout Inventory-Educators Survey (MBI-ES). Wilcoxon rank-sum and Kruskal-Wallis tests identified factors linked to anxiety, depression, and burnout. Variables with p ≤ 0.10 in univariate analysis were included in multivariate logistic regression, with cut-offs of 50 for SAS, 53 for SDS, 27 for Emotional Exhaustion (EE), 13 for Depersonalization (DP), and 31 for Personal Accomplishment (PA). A p ≤ 0.10 threshold was used to avoid omitting potential predictors.

The study found anxiety, depression, and burnout prevalence rates of 19.3%, 34.7%, and 74.5%, respectively (95% CI: 14.5-24.1; 28.9-40.6; 69.2-79.9). Junior high school teachers (OR = 0.47) and those with higher education (OR = 0.39) had a lower depression risk. Female teachers (OR = 1.96) had a higher risk of emotional exhaustion (EE), while older teachers (OR = 0.923) had a lower risk of reduced personal accomplishment (PA). Anxiety and depersonalization (DP) showed no significant associations.

The study found high rates of depression and burnout among teachers, influenced by educational level, school type, sex, and age. Authorities should address these issues by clarifying teacher responsibilities, providing mental health training, and establishing monitoring systems. As a cross-sectional study, it cannot determine causality, and further longitudinal research is needed to confirm these findings.

To explore the risk factors for malnutrition in patients with ulcerative colitis complicated with pyoderma gangrenosum and establish a nutritional risk prediction model for these patients.

A total of 277 patients with ulcerative colitis complicated with pyoderma gangrenosum treated from 2019 to 2024 were divided into malnutrition group (n=185) and normal nutrition group (n=92) according to whether malnutrition occurred. The data of 25 potential related factors pertaining to general demography, living and eating habits, and disease-related data were compared between the two groups. Lasso regression was used to screen the risk factors, and a nomogram model was established based on the screened factors and its prediction performance was assessed.

The patients in the malnutrition group and normal nutrition group showed significant differences in 21 factors including gender, age, education level, BMI, place of residence, course of disease, and SAS language score (P<0.05). Lasso regression analysis identified 6 factors associated with malnutrition in these patients, namely the duration of ulcerative colitis, activity of ulcerative colitis, duration of pyoderma gangrenosum, number of chronic diseases, SAS score, and sleep quality. The nomogram prediction model established based on these 6 factors had an AUC of 0.992 (95% CI: 0.984-1.000) for predicting malnutrition in these patients, and its application in 14 clinical cases achieved an accuracy rate of 100%.

The duration of ulcerative colitis, activity of colitis, duration of pyoderma gangrenosum, number of chronic diseases, anxiety, and sleep quality are closely related with malnutrition in patients with ulcerative colitis complicated by pyoderma gangrenosum, and the nomogram prediction model based on these factors can provide assistance for predicting malnutrition in these patients.

Depression is one of the most common mental disorders, with high rates of disability, particularly among women.

To explore the effects of suggestion therapy on anxiety, mood, and sleep-quality in middle-aged women with depression treated with escitalopram.

Overall, 102 female patients with depression aged 35-49 years were divided into control and experimental groups. The control group received oral escitalopram therapy, starting at a dose of 5 mg/day, which was gradually increased to 10-20 mg/day after 1 week for a total of 8 weeks. The experimental group received the suggested therapy based on the control group. The Self-Rating Depression Scale (SDS), Self-Rating Anxiety Scale (SAS), Profile of Mood States-Short Form, and Pittsburgh Sleep Quality Index (PSQI) were used to assess depression, anxiety, mood status, and sleep quality.

Before treatment, there were no significant differences in the SDS, SAS, Profile of Mood States, and PSQI scores between the two groups (P > 0.05). After treatment, compared to the control group and baseline, the SDS, SAS, tension-anxiety, depression-dejection, and confusion-bewilderment scores in the experimental group significantly decreased (P < 0.05), whereas sleep efficiency, sleep disturbance, hypnotics, and PSQI scores significantly increased (P < 0.05).

Suggestion therapy combined with escitalopram treatment can reduce the severity of depression and anxiety, change mood status, and improve sleep quality in middle-aged women with depression.

The persistent and recurring nature of Menière's Disease may pose psychological challenges for patients. The association between Menière's Disease and depression and anxiety remains inconclusive among pre-existing studies. This study seeks to review and synthesise existing evidence regarding the association between Menière's Disease and depression and anxiety.

Two authors independently searched PubMed, Embase and The Cochrane Library for observational or randomized studies investigating the association between Menière's Disease with depression or anxiety. Using a random-effects model, the prevalence of depression and anxiety among Menière's Disease patients were pooled using proportions, the standardized mean difference of depression and anxiety test scores between Menière's Disease patients and controls were compared, and maximally-adjusted risk ratios were pooled to determine the risk of depression and anxiety. Heterogeneity was assessed using the I2 test. The bias of studies was assessed using the Newcastle-Ottawa Scale (NOS) and the overall quality of evidence was determined using the Grading of Recommendations, Assessment, Development and Evaluations (GRADE) framework.

We included 35 observational studies with 15,890 patients. The prevalence of depression and anxiety among Menière's Disease patients were 34% (95% CI 18%-54%) and 23% (95% CI 16%-32%) respectively. Patients with Menière's Disease exhibited significantly elevated scores in both depression (SMD: 0.73, 95% CI 0.22-1.25) and anxiety (SMD: 0.687, 95% CI 0.228-1.146) assessments in comparison to healthy controls. However, no significant correlation was observed between Menière's Disease and the long-term risk of developing depression or anxiety.

There may be an association between Menière's Disease and depression and anxiety, but further studies are required to confirm these findings.

The timely alleviation and healing of anxiety is crucial for preventing anxiety disorders. This study explores innovative digital approaches for anxiety relief by integrating virtual reality (VR) and multimodal interaction theories and technologies with psychodrama therapy and breathing therapy from psychology. The research proposes an innovative method of breathing interaction based on olfactory interaction modalities and designs breathing interaction semantics aimed at anxiety healing through three types of breathing therapy. Using the Unreal Engine, VR gamified scenarios and interaction logic for levels were constructed, leading to the development of a multimodal immersive software interaction system and a prototype for VR hardware interaction that extends the breathing interaction modality. The effectiveness of the system for anxiety relief was validated through an EEG experiment involving 38 participants, supported by analysis of Topographic Maps, Band-Power Reports, ERP analysis, and qualitative data from the USE scale. This research confirms that the innovative integration of VR and breathing interaction modalities is effective for anxiety therapy, aiding users in promptly alleviating anxiety and simplifying the psychological healing process.

Globally, approximately one-third of adults are affected by 1 or multiple chronic diseases, posing a considerable threat to mental health, particularly in relation to mental disorders. The objective of our study was to investigate the associations between chronic diseases and anxiety levels, as well as to identify the risk factors that contribute to the occurrence of anxiety in patients with chronic diseases. This cross-sectional survey was conducted from January 1, 2023, to January 1, 2024 at the First People's Hospital of Hangzhou Lin'an District. The anxiety status was assessed by the tool of Zung Self-Rating Anxiety (SAS). A cohort of 50 patients was identified, among whom 23 (46%) were assessed as having anxiety, while 27 (54%) did not exhibit anxiety. Patients with anxiety had a higher level of existed in living alone compared to those without anxiety (P = .032). Notably, the SAS score of anxiety for patients with 4 chronic diseases (60.0 ± 11.2) was significantly higher compared to those with 1 chronic disease (41.2 ± 15.4, P = .034) and 2 chronic diseases (44.2 ± 13.2, P = .037). The analysis revealed that patients living alone were more likely to experience symptoms of anxiety compared to those living with family (odds ratio = 5.469; 95% confidence interval, 1.007-29.701, P = .049). Our findings substantiate the association between anxiety and chronic diseases. The significance of demographic factors in the manifestation of anxiety related to chronic diseases warrants further investigation.

To explore the effects of knowledge-attitude-practice (KAP) nursing and guided intervention on mental state, sleep quality, and self-efficacy of cancer patients.

Retrospectively, 106 cancer patients were collected and divided into the control (received routine nursing and psychological intervention) and observation groups (given KAP nursing combined guided intervention) following different nursing modalities. The psychological status of patients was evaluated by the Self-rating Anxiety Scale (SAS) and Self-rating Depression Scale (SDS). Disease uncertainty in patients was assessed by Mishel Uncertainty in Illness Scale (MUIS). The quality of life of patients was evaluated by using the short form 36 health survey questionnaire. Sleep quality was evaluated by the Pittsburgh Sleep Quality Index (PSQI). The knowledge level, coping ability, self-efficacy, and satisfaction with nursing work were observed.

Following nursing intervention, the scores decreased, with the observation group exhibiting lower scores in SAS, SDS, MUIS, and PSQI. The observation group demonstrated higher levels of cognitive functioning, self-efficacy, and nursing satisfaction and superior coping abilities. The quality of life of both groups after nursing was improved, with the observation group showing a higher score.

Guided intervention and KAP nursing can improve the mental status, sleep quality, and self-efficacy of cancer patients.

Scapulothoracic dissociation is a rare and serious type of trauma caused by musculoskeletal, vascular, and brachial plexus injuries owing to lateral displacement of the scapula with a strong blunt external force. Here, we describe the treatment of an open scapulothoracic dissociation patient and summarize the findings.

Premature ovarian insufficiency (POI), marked by ovarian function loss before age 40, is linked to a higher risk of dementia, including Alzheimer's disease (AD). However, the associated brain structural changes remain poorly understood.

We analyzed T1-weighted and diffusion tensor imaging in 33 idiopathic POI women and 51 healthy controls, using voxel-based, surface-based morphometry, and network analyses to assess gray matter volume (GMV), cortical thickness, and brain connectivity.

Women with POI showed significant GMV and cortical thickness reductions in the frontal, parietal, and temporal regions (p < 0.05), alongside impaired connectivity with key regions such as the hippocampus, thalamus, and amygdala (p < 0.05). Younger POI subgroups exhibited changes in more widespread brain regions. In additionally, notable atrophy was observed in specific hippocampal and thalamic subregions in POI (p < 0.05).

This preliminary study suggests early neurodegenerative patterns in POI, potentially contributing to dementia risk. Further research is needed to explore the underlying mechanisms and potential interventions.

We evaluated brain structural changes in participants with idiopathic premature ovarian insufficiency (POI). The observed brain alterations in POI participants closely resemble those seen in early dementia, including regions specifically associated with Alzheimer's disease (AD). These findings highlight the critical need for early interventions to reduce the long-term risks of cognitive impairment and dementia in women with POI.

Background/Objectives: Knee osteoarthritis (OA) is a degenerative chronic disease characterized by a reduction in articular cartilage, as well as pain and functional limitations. We evaluated both the efficacy and safety of cross-linked high-molecular-weight hyaluronic acid in patients with knee OA. Methods: In this observational prospective single-arm study, a cross-linked high-molecular-weight hyaluronic acid (DIART ONE 90 mg in 3 mL) was administered in single injections to 50 patients aged 18-65 years, with a follow-up at 3, 6, and 12 months. Several scores were evaluated, including the Knee Injury and Osteoarthritis Outcome Score as the primary outcome measure and the Visual Analogue Scale, Timed Up and Go Test, Six-Minute Walking Test, General Health Assessment with 36-Item Short Form Health Survey, Zung's Self-Rating Anxiety Scale, and Zung's Self-Rating Depression Scale as secondary outcome measures. Both physicians and patients knew the kind of treatment they received. Results: During the follow-ups, we observed a statistically significant improvement in clinical scores at 3 and 6 months, with a decrease in clinical benefit at 12 months. Functional and psychological benefits were significant at 3, 6, and 12 months. No side effects were described except pain associated with the site of injection. Conclusions: In conclusion, we documented that cross-linked high-molecular-weight hyaluronic acid (DIART ONE 90 mg in 3 mL) represents an effective option in the management of mild-moderate osteoarthritis.

Compared with the general population, patients with end-stage renal disease (ESRD) undergoing maintenance hemodialysis (ESHD) exhibit a higher incidence of cognitive impairment. Early identification of cognitive impairment in these patients is crucial for reducing disability and mortality rates. Examining the characteristics of static and dynamic regional spontaneous activities in ESHD cases may provide insights into neuropathological damage in these patients.

Resting-state functional magnetic resonance images were acquired from 40 patients with early ESHD (3 or 4 times/week for more than 30 days but less than 12 months) and 31 healthy matched controls. Group differences in regional static and dynamic regional homogeneity (ReHo) were identified, and correlations examined with clinical variables, including neuropsychological scale scores, while controlling for covariates. Receiving operating characteristic (ROC) curve analyses were conducted to assess the accuracy of ReHo abnormalities for predicting cognitive decline among early ESHD.

The ESHD group exhibited significantly reduced static and dynamic ReHo in the temporal and parietal lobes, including regions involved in basal ganglia-thalamus-cortex circuits, the default mode network, and ventral attentional network. Several static and dynamic ReHo abnormalities (including those in the right parietal and left middle temporal gyrus) were significantly correlated with neurocognitive scale scores. In addition, the dynamic ReHo value of the left superior temporal gyrus was positively correlated with depression scale scores. Comparing the ROC curve area revealed that numerous brain regions with altered ReHo can effectively distinguish between patients with ESHD and those without cognitive impairment.

Our study found that spontaneous activity alterations located in the basal ganglia-thalamus-cortex circuit, default mode network, and ventral attentional network are associated with the severity of cognitive deficits and negative emotion in early ESHD patients. These findings provide further insight into the relationship between cognitive impairment and underlying neuropathophysiological mechanisms underlying the interplay between the kidneys and the nervous system in ESRD patients, and provide further possibilities for developing effective clinical intervention measures.

To explore the impact of intermittent oro-esophageal tube feeding combined with continuous nursing intervention on postoperative recovery in patients with intracerebral hemorrhage.

A retrospective study was conducted on 212 patients with intracerebral hemorrhage after surgery who were admitted to the Third People's Hospital of Yibin from January 2022 to December 2023. Patients were divided into two groups: the control group (108 patients), who received intermittent oro-esophageal tube feeding, and the observation group (104 patients), who received intermittent oro-esophageal tube feeding combined with continuous nursing intervention. Clinical data, National Institutes of Health Stroke Scale (NIHSS), Glasgow Coma Scale (GCS), and the Activity of Daily Living (ADL) scores, psychological status, nutritional indices (albumin, hemoglobin, transferrin), compliance, and nursing satisfaction were compared between the groups.

Post-intervention, the observation group had significantly lower NIHSS scores and higher GCS, hemoglobin, albumin, transferrin, and ADL scores compared to the control group (all P < 0.05). Additionally, ESCA scores in the observation group were significantly higher than those in the control group (P < 0.05). Nursing satisfaction in the observation group was 97.12%, compared to 83.3% in the control group (P = 0.033).

Intermittent oro-esophageal tube feeding combined with continuous nursing intervention improves neurological deficits, reduces brain injury, and promotes recovery of motor function and daily living abilities in patients with intracerebral hemorrhage after surgery.

The present study aimed to investigate the effects of collaborative pain management by healthcare providers on sleep quality and self-efficacy in perioperative lumbar disc herniation patients. A total of 300 lumbar disc herniation patients admitted to our hospital from February 2022 to February 2023 were selected as the research subjects. They were divided into a study group (receiving collaborative pain management by healthcare providers) and a control group (receiving conventional pain management), with 150 patients in each group. Surgical parameters, pain levels at different time points, as well as pre- and post-intervention pain levels, sleep quality, self-efficacy, lumbar function, patients' satisfaction, and psychological status were compared between the two groups. There were no significant differences between the two groups in terms of gender, age, smoking, alcohol consumption, body mass index, disease duration, type and location of lumbar disc herniation, and comorbidities (P > 0.05). Surgical duration, blood loss, and time to first meal did not significantly differ between the two groups (P > 0.05). However, the study group had significantly shorter times to first ambulation, first gas passage, first bowel movement, and length of hospital stay compared to the control group (P < 0.05). Pre-intervention comparisons of pain levels showed no significant differences between the two groups (P > 0.05). Postoperatively, at 12, 24, 48, and 72 h, the study group had lower pain levels than the control group, with statistically significant differences (P < 0.05). Pre-intervention comparisons of daytime dysfunction, hypnotic drug use, sleep disturbances, sleep efficiency, sleep duration, time to fall asleep, and sleep quality revealed no significant differences between the two groups (P > 0.05). However, post-intervention, the study group exhibited significantly lower PSQI scores in daytime dysfunction, hypnotic drug use, sleep disturbances, sleep efficiency, sleep duration, time to fall asleep, and sleep quality compared to the control group (P < 0.05). Pre-intervention comparisons of pain management, physical function, and symptom coping showed no significant differences between the two groups (P > 0.05). After intervention, the study group demonstrated significantly better pain management, physical function, and symptom coping compared to the control group (P < 0.05). Before the intervention, subjective symptoms, bladder function, daily activity limitation, and clinical signs showed no significant differences between the two groups (P > 0.05). After the intervention, however, the study group exhibited significantly better subjective symptoms, bladder function, reduced daily activity limitation, and clinical signs compared to the control group (P < 0.05). Before the intervention, there were no significant difference in patients' satisfaction, anxiety score, and depression score between the two groups (P > 0.05). After the intervention, the study group showed lower anxiety score and depression score, and higher satisfaction with the nursing intervention compared to the control group (all P < 0.05). Collaborative pain management by healthcare providers can effectively improve sleep quality and enhance self-efficacy in perioperative lumbar surgery patients, and holds promise for clinical application.

Smoking is associated with significant alterations in sleep architecture. Previous studies have revealed changes in the subjective sleep of young smokers, but research on objective sleep assessment using polysomnography (PSG) is limited. This study aims to explore electroencephalography (EEG) power and sleep spindle activity during the sleep of young smokers, as well as to assess the relationship between sleep and smoking variables.

We collected overnight PSG data from 19 young smokers and 16 non-smokers and assessed nicotine dependence and cumulative effects using the Fagerstrom Nicotine Dependence Test (FTND) and pack-year. Power spectral analysis and sleep spindle detection are used to analyze EEG activity during sleep.

Compared to the non-smokers, young smokers showed increased alpha power in the frontal and central regions and decreased delta power in the central region. The frontal region showed enhanced sleep spindle duration and density. Notably, both relative alpha power and sleep spindle duration in frontal showed a positive correlation with Pack-year.

Sleep EEG power and sleep spindle activity in frontal may serve as biomarkers to assess the sleep quality of young smokers. It may improve the understanding of the relationship of sleep and smoking.