Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan

doi:10.4239/wjd.v6.i1.136

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Feb 15, 2015 (publication date) through Nov 21, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Feb 15, 2015; 6(1): 136-144
Published online Feb 15, 2015. doi: 10.4239/wjd.v6.i1.136

Table 1 Sodium-glucose cotransporter 2 selectivity of sodium-glucose cotransporter 2 inhibitors

	Company	IC₅₀ for human SGLT1/SGLT2 (nmol/L)	SGLT2 selectivity (fold)
Phlorizin		210/34.6	6
Ipragliflozin	Astellas	1876/7.38	254
canagliflozin	Johnson and Johnson Mitsubishi Tanabe	684/4.4	155
Dapagliflozin	Bristol-Myers Squibb AstraZeneca	1391/1.12	1242
Empagliflozin	Boehringer Ingelheim	8300/3.1	2680
Tofogliflozin	Chugai	8444/2.9	2912
luseogliflozin	Taisho	3990/2.26	1770

SGLT2 selectivity was calculated by using the following formula: IC₅₀ value for SGLT1/IC₅₀ value for SGLT2. IC₅₀: Half maximal (50%) inhibitory concentration; SGLT: Sodium–glucose cotransporter.

Citation: Ohkura T. Ipragliflozin: A novel sodium-glucose cotransporter 2 inhibitor developed in Japan. World J Diabetes 2015; 6(1): 136-144
URL: https://www.wjgnet.com/1948-9358/full/v6/i1/136.htm
DOI: https://dx.doi.org/10.4239/wjd.v6.i1.136