Effect of treatment of overt hypothyroidism on insulin resistance

Table 1 Laboratory and anthropometric parameters in hypothyroid patients versus euthyroid subjects

Parameter	Hypothyroid(mean ± SD)	Euthyroid(mean ± SD)	P-value
Age (yr)	33.2 ± 10.4	35.7 ± 9.1	0.444
BMI	31.1 ± 6.8	32.2 ± 6.7	0.607
TSH	22.4 ± 36.2	2.9 ± 1.5	0.010
FT4	11.2 ± 4.0	13.7 ± 2.1	0.013
FT3	4.4 ± 1.0	4.5 ± 0.5	0.557
FPG	93.5 ± 14.7	89.8 ± 13.9	0.432
FI	10.6 ± 8.1	11.8 ± 6.3	0.621
IR	2.5 ± 2.1	2.6 ± 1.5	0.883
TG	144.8 ± 85.4	97.9 ± 36.1	0.050
TCH	195.0 ± 37.9	189.0 ± 29.9	0.586

BMI: Body mass index; TSH: Thyrotropin; FPG: Fasting plasma glucose; FI: Fasting insulin; IR: Insulin resistance; FT4: Free tetraiodothyronine; FT3: Free triiodothyronine; TG: Triglycerides; TCH: Total cholesterol.

Table 2 Correlation between different variables before thyroxine replacement

		TSH	FT4	FT3
TG	r	0.496	-0.321	-0.585
	P	0.009	0.102	0.001
TCH	r	0.196	-0.176	-0.420
	P	0.327	0.380	0.029

TSH: Thyrotropin; FT4: Free tetraiodothyronine; FT3: Free triiodothyronine; TG: Triglycerides; TCH: Total cholesterol; R: Relative coefficient.

Table 3 Comparison between different variables before and after thyroxine replacement

Variable	Before treatment (mean ± SD)	After treatment(mean ± SD)	P-value
BMI	31.1 ± 6.8	31.4 ± 7.2	0.485
TSH	22.4 ± 36.2	3.0 ± 1.9	0.010
FT4	11.2 ± 4.0	14.5 ± 2.6	0.001
FT3	4.4 ± 1.0	4.7 ± 0.7	0.037
FPG	93.5 ± 14.7	90.2 ± 12.2	0.216
FI	10.6 ± 8.1	13.6 ± 7.3	0.047
IR	2.5 ± 2.1	3.0 ± 1.9	0.204
TG	144.8 ± 85.4	128.1 ± 64.8	0.175

BMI: Body mass index; TSH: Thyrotropin; FPG: Fasting plasma glucose; FI: Fasting insulin; IR: Insulin resistance; FT4: Free tetraiodothyronine; FT3: Free triiodothyronine; TG: Triglycerides; TCH: total cholesterol.