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World J Diabetes. Aug 15, 2013; 4(4): 157-161
Published online Aug 15, 2013. doi: 10.4239/wjd.v4.i4.157
Published online Aug 15, 2013. doi: 10.4239/wjd.v4.i4.157
Effect of treatment of overt hypothyroidism on insulin resistance
Aml Mohamed Nada, Department of Internal Medicine, Unit of Endocrinology, Diabetes and Metabolism, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt
Correspondence to: Dr. Aml Mohamed Nada, MD, Lecturer, Department of Internal Medicine, Unit of Endocrinology, Diabetes and Metabolism, Faculty of Medicine, Mansoura University, El-Gomhoria Street, Mansoura 35516, Egypt. aml-nadanoha@yahoo.com
Telephone: +966-56-8089574
Received: March 30, 2013
Revised: July 2, 2013
Accepted: July 9, 2013
Published online: August 15, 2013
Processing time: 138 Days and 4.7 Hours
Revised: July 2, 2013
Accepted: July 9, 2013
Published online: August 15, 2013
Processing time: 138 Days and 4.7 Hours
Core Tip
Core tip: Thyroid dysfunction is the second most common endocrine disorder after diabetes mellitus. Both diseases are strong associated. Hypothyroidism is claimed to cause insulin resistance. Some available reports are in agreement and others are against this suggestion. In our study, we did not find a significant effect of hypothyroidism or thyroxine replacement on insulin resistance as calculated by insulin resistance was estimated using homeostasis model assessment. Thyroxine therapy leads to a significant reduction of total cholesterol but it does not change triglycerides. This may partially explain the association between hypothyroidism and dyslipidaemia as well as cardiovascular risk.