Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome

doi:10.4239/wjd.v4.i3.64

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Jun 15, 2013 (publication date) through Dec 21, 2024

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World Journal of Diabetes

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1948-9358

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Diabetes. Jun 15, 2013; 4(3): 64-69
Published online Jun 15, 2013. doi: 10.4239/wjd.v4.i3.64

Table 1 Mean body mass index and cardiometabolic disease risk factor values among women with polycystic ovary syndrome before and 1 year after gastric bypass surgery by ethnic group

		Pre-surgery	1-yr follow up
	n⁴	Estimate (95%CI)	Estimate (95%CI)
Hispanic (n = 257)¹
BMI (kg/m²)	257	45.5 (44.7-46.4)	35.5 (34.6-36.3)
Weight (kg)	257	118.4 (115.8-120.9)	92.3 (89.8-94.7)
EWL (%)	257		54.5 (1.9)
Percent weight loss (%)	257		22.0 (0.6)
Total cholesterol (mg/dL)	28	198.1 (190.4-205.8)	160.2 (154.0-166.4)
HDL cholesterol (mg/dL)	28	49.5 (46.8-52.1)	48.7 (46.4-51.0)
LDL cholesterol (mg/dL)	24	120.9 (112.9-128.9)	91.0 (86.0-95.9)
Triglycerides (mg/dL)	28	148.6 (128.7-168.6)	104.8 (93.9-115.8)
Hemoglobin A1c (%)	58	6.2 (6.0-6.3)	5.6 (5.5-5.6)
ALT (U/L)	99	28.1 (25.8-30.4)	23.0 (20.7-25.4)
AST (U/L)	100	23.5 (22.0-25.0)	21.6 (19.8-23.4)
Non-Hispanic black (n = 97)²
BMI (kg/m²)	97	46.8 (45.5-48.2)	37.7 (36.2-39.2)
Weight (kg)	97	128.2 (123.5-132.8)	103.1 (98.5-107.8)
EWL (%)	97		47.5 (3.1)
Percent weight loss (%)	97		19.5 (1.0)
Total cholesterol (mg/dL)	6	184.5 (166.6-202.3)	154.7 (140.2-169.2)
HDL cholesterol (mg/dL)	6	50.6 (45.0-56.1)	53.0 (47.4-58.6)
LDL cholesterol (mg/dL)	6	111.7 (97.0-126.5)	88.9 (76.4-101.3)
Triglycerides (mg/dL)	6	99.7 (80.0-119.5)	70.0 (56.8-83.3)
Hemoglobin A1c (%)	15	6.4 (5.9-6.8)	5.8 (5.3-6.3)
ALT (U/L)	23	18.6 (16.3-20.9)	16.0 (12.6-19.4)
AST (U/L)	23	19.2 (17.4-20.9)	18.6 (16.4-20.7)
Non-Hispanic white (n = 35)³
BMI (kg/m²)	35	45.7 (43.2-48.1)	36.7 (34.4-39.0)
Weight (kg)	35	123.9 (116.5-131.2)	99.58 (92.3-106.9)
EWL (%)	35		50.2 (5.2)
Percent weight loss (%)	35		20.2 (1.7)
Total cholesterol (mg/dL)	7	200.9 (178.1-223.7)	172.8 (160.5-185.2)
HDL cholesterol (mg/dL)	7	49.7 (44.3-55.1)	49.6 (43.8-55.4)
LDL cholesterol (mg/dL)	6	124.2 (104.2-144.2)	96.6 (80.4-112.9)
Triglycerides (mg/dL)	7	160.5 (120.9-200.1)	137.8 (104.9-170.7)
Hemoglobin A1c (%)	5	6.3 (5.8-6.8)	5.9 (5.0-6.8)
ALT (U/L)	10	30.0 (23.7-36.0)	22.0 (16.6-27.4)
AST (U/L)	10	23.7 (19.7-27.8)	20.8 (16.6-25.0)

¹Differences were statistically significant (P < 0.001), except for high-density lipoprotein (HDL) cholesterol and aspartate aminotransferase (AST);

²All differences were statistically significant (P < 0.05), except for HDL cholesterol, hemoglobin A1c (HbA1c), alanine aminotransferase (ALT) and AST were not significant;

³All differences were statistically significant (P < 0.05) except for HDL cholesterol, triglycerides, HbA1c, ALT and AST; ⁴Number of patients with data at baseline and 1 year follow up. BMI: Body mass index; EWL: Estimated weight loss; LDL: Low-density lipoprotein.

Table 2 Ethnic group comparison of change in mean cardiometabolic disease risk factors among women with polycystic ovary syndrome 12 mo, after gastric bypass surgery performed between 2001 and 2010

Anthropometric	Group	Estimated change	P value	P value
measures		12 mo after		Ethnic group
		surgery (SE)		comparisons
BMI (kg/m²)	Overall	9.7 (0.3)	< 0.0001	NHB	NHW
	Hispanic	10.1 (0.3)	< 0.0001	0.09	0.19
	NHB	9.1 (0.5)	< 0.0001	-	0.87
	NHW	9.0 (0.8)	< 0.0001	0.87	-
Weight (kg)	Overall	25.7 (0.7)	< 0.0001	NHB	NHW
	Hispanic	26.1 (0.8)	< 0.0001	0.49	0.40
	NHB	25.0 (1.3)	< 0.0001	-	0.76
	NHW	24.3 (2.0)	< 0.0001	0.76	-
Total cholesterol (mg/dL)	Overall	35.1 (3.6)	< 0.0001	NHB	NHW
	Hispanic	37.9 (4.2)	< 0.0001	0.36	0.21
	NHB	29.7 (7.8)	0.01	-	0.63
	NHW	28.1 (10.8)	0.04	0.63	-
HDL cholesterol (mg/dL)	Overall	-0.1 (1.2)	0.95	NHB	NHW
	Hispanic	0.7 (1.5)	0.64	0.26	0.96
	NHB	-2.4 (2.6)	0.40	-	0.36
	NHW	0.1 (2.9)	0.98	0.36	-
LDL cholesterol (mg/dL)	Overall	27.8 (3.4)	< 0.0001	NHB	NHW
	Hispanic	29.9 (4.3)	< 0.0001	0.32	0.89
	NHB	22.9 (6.2)	0.01	-	0.51
	NHW	27.6 (7.3)	0.01	0.51	-
Triglycerides (mg/dL)	Overall	40.1 (7.6)	< 0.0001	NHB	NHW
	Hispanic	43.8 (10.4)	0.0003	0.36	0.26
	NHB	29.7 (7.5)	0.01	-	0.64
	NHW	22.7 (12.8)	0.13	0.64	-
Hemoglobin A1c (%)	Overall	0.6 (0.1)	< 0.0001	NHB	NHW
	Hispanic	0.6 (0.1)	< 0.0001	0.77	0.38
	NHB	0.5 (0.3)	0.11	-	0.66
	NHW	0.37 (0.3)	0.31	0.66	-
ALT (U/L)	Overall	4.9 (1.1)	< 0.0001	NHB	NHW
	Hispanic	5.1 (1.3)	0.0002	0.16	0.38
	NHB	2.6 (1.4)	0.08	-	0.16
	NHW	7.9 (3.7)	0.06	0.16	-
AST (U/L)	Overall	1.8 (0.8)	0.04	NHB	NHW
	Hispanic	1.9 (1.1)	0.07	0.37	0.66
	NHB	0.6 (1.1)	0.56	-	0.40
	NHW	2.9 (2.8)	0.33	0.40	-

NHB: Non-Hispanic black; NHW: Non-Hispanic white; BMI: Body mass index; EWL: Estimated weight loss; HDL: High-density lipoprotein; LDL: Low-density lipoprotein; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.

Citation: Gomez-Meade CA, Lopez-Mitnik G, Messiah SE, Arheart KL, Carrillo A, de la Cruz-Muñoz N. Cardiometabolic health among gastric bypass surgery patients with polycystic ovarian syndrome. World J Diabetes 2013; 4(3): 64-69
URL: https://www.wjgnet.com/1948-9358/full/v4/i3/64.htm
DOI: https://dx.doi.org/10.4239/wjd.v4.i3.64