Efficacy comparison of multipoint and single point scanning panretinal laser photocoagulation in non-proliferative diabetic retinopathy treatment

Table 1 Comparison of baseline clinical data, n (%)

Clinical parameters	Multi-point mode, n = 26	Single point mode, n = 23	t/χ²	P value
Male sex	16 (61.64)	12 (52.17)	0.437	0.509
Average age in years	44.92 ± 6.35	44.22 ± 6.40	0.384	0.703
Average body mass index in kg/m2	22.80 ± 2.87	23.95 ± 2.50	1.486	0.144
Smoking	3 (11.54)	4 (17.39)	0.341	0.559
Alcohol drinker	3 (11.54)	3 (13.04)	0.026	0.873
ALT in U/L	29.11 ± 14.54	29.83 ± 14.13	0.175	0.862
AST in U/L	34.22 ± 16.64	36.20 ± 17.02	0.411	0.683
FBG in mmol/L	5.20 ± 0.85	5.30 ± 1.01	0.376	0.708
Creatinine in μmol/L	72.48 ± 14.73	63.26 ± 17.67	1.992	0.052
Creatine kinase in U/L	181.87 ± 135.88	177.37 ± 114.54	0.124	0.902
Uric acid in μmol/L	373.43 ± 95.80	389.90 ± 96.51	0.599	0.552
Concurrent diseases
Hypertension	2 (7.69)	4 (17.39)	1.068	0.301
Nonalcoholic fatty liver disease	2 (7.69)	1 (4.35)	0.238	0.626
Liver cirrhosis	1 (3.85)	0 (0.00)	0.903	0.342

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; FBG: Fasting blood glucose.

Table 2 Comparison of surgical indicators

Groups	Eyes	Laser energy in mW	Energy density in mW·ms/μm2
Multipoint group	46	551.93 ± 64.25	0.51 ± 0.08
Single point group	40	540.64 ± 73.77	2.02 ± 0.92
t	-	0.759	11.094
P value	-	0.450	0.000

Table 3 Distinctions in therapy response rates, n (%)

Groups	Eyes	Changes in vision
		Improve	Unchanged	Decline
Multipoint group	46	17 (36.96)	26 (56.52)	3 (6.52)
Single point group	40	8 (20.00)	25 (62.50)	7 (17.50)
χ²	-	2.983	0.574	2.509
P value	-	0.084	0.317	0.113

Table 4 Comparison of LogMAR best-corrected visual acuity before and after therapy

Groups	Eyes	Pre-therapy	1 month after surgery	6 months after surgery	12 months after surgery
Multipoint group	46	0.65 ± 0.08	0.54 ± 0.10	0.49 ± 0.11	0.51 ± 0.10
Single point group	40	0.68 ± 0.09	0.60 ± 0.10	0.48 ± 0.09	0.53 ± 0.06
t	-	1.637	2.775	0.457	1.103
P value	-	0.105	0.007	0.649	0.273

Table 5 Comparison of central macular thickness before and after therapy

Groups	Eyes	Pre-therapy	1 month after surgery	6 months after surgery	12 months after surgery
Multipoint group	46	446.36 ± 175.99	366.74 ± 102.17	346.41 ± 85.47	345.72 ± 82.03
Single point group	40	455.08 ± 118.94	423.35 ± 94.54	359.14 ± 76.18	349.35 ± 86.54
t	-	0.265	2.653	0.724	0.200
P value	-	0.792	0.010	0.471	0.842

Table 6 Comparison of the incidence of adverse reactions, n (%)

Groups	Cases	Iritis	Vitreous hemorrhage	Tractional retinal detachment	Overall incidence
Multipoint group	26	1 (3.85)	1 (3.85)	0 (0.00)	2 (7.69)
Single point group	23	2 (8.70)	1 (4.35)	1 (4.35)	4 (17.39)
Fisher	-	-	-	-	1.068
P value	-	-	-	-	0.301