Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine

Table 1 Microbiome symbiosis plays a crucial role in regulating metabolism and reducing the risks for diabetes

Item	Role of microbiome symbiosis in regulating metabolism and reducing the risks for diabetes
1	Gut microbiota dysbiosis results in the production of short chain fatty acids such as butyric acid, propionic acid, and acetic acid, which will ruin the intestinal barrier integrity, activate inflammatory signaling cascade response and cause damage to multiple organs
2	Trimethylamine nitrogen oxide produced by the gut microbiota will increase the accumulation of cholesterol, which will lead to insulin resistance and raise the risk for diabetes
3	It is demonstrated that changes in the gut microbiota groups have an effect on intestinal permeability and inflammation in diabetes