Li YY, Guan RQ, Hong ZB, Wang YL, Pan LM. Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine. World J Diabetes 2024; 15(8): 1712-1716 [PMID: 39192853 DOI: 10.4239/wjd.v15.i8.1712]
Corresponding Author of This Article
Li-Min Pan, MD, Associate Chief Physician, Department of Endocrinology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 411 Guogeli Avenue, Nangang District, Harbin 150001, Heilongjiang Province, China. 2621902358@qq.com
Research Domain of This Article
Endocrinology & Metabolism
Article-Type of This Article
Minireviews
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Diabetes. Aug 15, 2024; 15(8): 1712-1716 Published online Aug 15, 2024. doi: 10.4239/wjd.v15.i8.1712
Advances in the treatment of diabetic peripheral neuropathy by modulating gut microbiota with traditional Chinese medicine
Li-Min Pan, Yao-Lei Wang, Zhi-Bo Hong, Rui-Qian Guan, Ye-Yao Li
Ye-Yao Li, Zhi-Bo Hong, Yao-Lei Wang, Li-Min Pan, Department of Endocrinology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China
Rui-Qian Guan, Department of Tuina, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150001, Heilongjiang Province, China
Author contributions: Li YY, Guan RQ, Hong ZB, Wang YL, and Pan LM contributed to the writing, revising and proofreading of the manuscript.
Conflict-of-interest statement: There is no conflict-of-interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: Https: //creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Li-Min Pan, MD, Associate Chief Physician, Department of Endocrinology, The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 411 Guogeli Avenue, Nangang District, Harbin 150001, Heilongjiang Province, China. 2621902358@qq.com
Received: April 30, 2024 Revised: June 6, 2024 Accepted: June 20, 2024 Published online: August 15, 2024 Processing time: 87 Days and 4.1 Hours
Abstract
Diabetic peripheral neuropathy (DPN) is one of the strongest risk factors for diabetic foot ulcers (neuropathic ulcerations) and the existing ulcers may further deteriorate due to the damage to sensory neurons. Moreover, the resulting numbness in the limbs causes difficulty in discovering these ulcerations in a short time. DPN is associated with gut microbiota dysbiosis. Traditional Chinese medicine (TCM) compounds such as Shenqi Dihuang Decoction, Huangkui Capsules and Qidi Tangshen Granules can reduce the clinical symptoms of diabetic nephropathy by modulating gut microbiota. The current review discusses whether TCM compounds can reduce the risk of DPN by improving gut mic-robiota.
Core Tip: Diabetic peripheral neuropathy (DPN) is associated with gut microbiota dysbiosis. Traditional Chinese medicine (TCM) compounds such as Shenqi Dihuang Decoction, Huangkui Capsules and Qidi Tangshen Granules can reduce the clinical symptoms of diabetic nephropathy by modulating gut microbiota. In this review, the authors discusse whether TCM compounds can reduce the risk of DPN by improving gut microbiota.
